Evidence map›Paper›PMID 35291655›Full record

ReviewImmune network2022

The Role of T Cells in Obesity-Associated Inflammation and Metabolic Disease.

Chan-Su Park, Nilabh Shastri

Open access · diamondAbstract readReview
In one paragraph

Review in Immune network, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed
8.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 57 citations in OpenAlex.

  1. Review
  2. Article
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  4. Review
  5. Review
  6. Article
  7. Article
  8. Insulin Resistance and Inflammation.International journal of molecular sciences · 2026
    Review
  9. Review
  10. Article
  11. Associations of child and adolescent obesity with the risk of neuroinflammatory diseases: analysis of data from a global health-care database.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025
    Article
  12. The potential role of GLP-1 receptor agonists in the management of psoriatic disease: a scoping review.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2025
    Article
  13. Review
  14. Article
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  19. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Chan-Su ParkDepartment of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.ORCID https://orcid.org/0000-0003-4968-8304
Nilabh ShastriDepartment of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.ORCID https://orcid.org/0000-0002-8060-3025
Johns Hopkins University · US

Funding

Antigen Processing in the Secretory PathwayR37AI060040 · NIAID · UNIVERSITY OF CALIFORNIA BERKELEY · PI SADEGH-NASSERI, SCHEHERAZADE · 2012 to 2021
$4.2M
Immune Surveillance of Antigen Processing PathwayR01AI130210 · NIAID · UNIVERSITY OF CALIFORNIA BERKELEY · PI SADEGH-NASSERI, SCHEHERAZADE · 2017 to 2021
$2.8M
Unconventional Sources of Peptides for Antigen PresentationR01AI121174 · NIAID · UNIVERSITY OF CALIFORNIA BERKELEY · PI SADEGH-NASSERI, SCHEHERAZADE · 2017 to 2022
$2.7M
NIAID NIH HHS R01 AI121174NIAID NIH HHS R01 AI130210NIAID NIH HHS R37 AI060040
6 · The paper itself

Abstract

Chronic inflammation plays a critical role in the development of obesity-associated metabolic disorders such as insulin resistance. Obesity alters the microenvironment of adipose tissue and the intestines from anti-inflammatory to pro-inflammatory, which promotes low grade systemic inflammation and insulin resistance in obese mice. Various T cell subsets either help maintain metabolic homeostasis in healthy states or contribute to obesity-associated metabolic syndromes. In this review, we will discuss the T cell subsets that reside in adipose tissue and intestines and their role in the development of obesity-induced systemic inflammation.

Indexed as

Insulin resistanceMetabolic diseasesObese miceObesity-associated inflammationT cells

Identifiers

PMID35291655
PMCPMC8901709
OpenAlexW4214871516

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.