Evidence map›Paper›PMID 35291613›Full record

ArticleReports of biochemistry & molecular biology2022

Relationship Between IL-2, IL-17 Concentrations, and Serum Creatinine Levels in Men with Chronic Kidney Diseases.

Khalid Farouq Al-Rawi, Hameed Hussein Ali, Manaf Abdulrahman Guma, Bilal Jasir Mohammed Aldahham, Shakir Faris Tuleab Alaaraji, Osamah Al-Ani, Aus Tariq Ali

Open access · goldAbstract read
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In one paragraph

Article in Reports of biochemistry & molecular biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 22 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Khalid Farouq Al-RawiDepartment of Chemistry, College of Science, University of Anbar, Al-anbar Province, Iraq.
Hameed Hussein AliDepartment of Chemistry, College of Science, University of Anbar, Al-anbar Province, Iraq.
Manaf Abdulrahman GumaDepartment of Applied Chemistry, College of Applied Sciences, University of Anbar, Al-anbar Province, Iraq.
Bilal Jasir Mohammed AldahhamDepartment of Applied Chemistry, College of Applied Sciences, University of Anbar, Al-anbar Province, Iraq.
Shakir Faris Tuleab AlaarajiDepartment of Chemistry, College of Education for pure Science, University of Anbar, Al-anbar Province, Iraq.
Osamah Al-AniYarmouk Academic Hospital, Baghdad, Iraq.
Aus Tariq AliUniversity of Anbar, Al-anbar Province, Iraq.
University of Anbar · IQAl Yarmouk University College · IQ

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Chronic kidney disease (CKD), is a major public health challenge worldwide. It is more prevalent in developed countries compared with the rest of the world, due to the higher rates of life expectancy and unhealthy lifestyle related factors. This aim of the current study is to evaluate the relationship between interleukins IL-2 and IL-17 concentrations and kidney function markers in men with CKD. Methods: Forty-five men with CKD and seventy controls were enrolled in the current study to assess the relationship between interleukin-2 (IL-2), interleukin-17 (IL-17), and CKD parameters. Fasting blood samples were collected from patients with CKD and their controls at same time. Serum IL-2, and IL-17 were measured in patients with CKD and their controls, and then the relationship between these interleukins and serum creatinine, serum urea, serum uric acid and urine albumin were evaluated. Results: A significant relationship was detected between IL-2 (p< 0.001), IL-17 (p< 0.001) levels and serum creatinine concentrations. The significant increase of IL-2 and IL-17 levels were also paralleled with a significant increase in serum urea (p< 0.001), and urine albumin (p< 0.001) concentrations respectively. Conclusion: IL-2 and IL-17 may play a critical role in the pathophysiology of CKD. The significant increase of IL-2 and IL-17 is associated with significantly high concentrations of creatinine, serum urea and urine albumin suggesting that these interleukins may be used as targets for future biomarkers and molecular therapy. However, due to limited sample size of the current study, larger prospective cohorts are needed to confirm these observations.

Indexed as

Chronic kidney diseaseInterleukinsSerum creatinineSerum ureaUrine albumin

Identifiers

PMID35291613
PMCPMC8903360
OpenAlexW4226275501

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.