Evidence map›Paper›PMID 35291294›Full record

ArticlebioRxiv : the preprint server for biology2022

Low expression of EXOSC2 protects against clinical COVID-19 and impedes SARS-CoV-2 replication.

Tobias Moll, Valerie Odon, Calum Harvey, Mark O Collins, Andrew Peden, John Franklin, Emily Graves, Jack N G Marshall, Cleide Dos Santos Souza, Sai Zhang and 8 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

18 authors at 4 institutions in 2 countries.

Tobias MollSheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield, UK.
Valerie OdonMedical Research Council Human Immunology Unit, Medical Research Council Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.
Calum HarveySheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield, UK.
Mark O CollinsSchool of Biosciences, University of Sheffield, Sheffield, United Kingdom.
Andrew PedenSchool of Biosciences, University of Sheffield, Sheffield, United Kingdom.
John FranklinSheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield, UK.
Emily GravesSheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield, UK.
Jack N G MarshallSheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield, UK.
Cleide Dos Santos SouzaSheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield, UK.
Sai ZhangDepartment of Genetics, Stanford University School of Medicine, Stanford, CA, USA.
Mimoun AzzouzSheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield, UK.
David GordonDepartment of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, CA, USA.
Nevan KroganDepartment of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, CA, USA.
Laura FerraiuoloSheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield, UK.
Michael P SnyderDepartment of Genetics, Stanford University School of Medicine, Stanford, CA, USA.
Pamela J ShawSheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield, UK.
Jan RehwinkelMedical Research Council Human Immunology Unit, Medical Research Council Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.
Johnathan Cooper-KnockSheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield, UK.
University of Sheffield · GBStanford University · USUniversity of California, San Francisco · USUniversity of Oxford · GB

Funding

PRODUCTION CENTER FOR MAPPING REGULATORY REGIONS OF THE HUMAN GENOMEUM1HG009442 · NHGRI · STANFORD UNIVERSITY · PI SNYDER, MICHAEL P. · 2017 to 2021
$20.1M
Stanford Islet Research CoreP30DK116074 · NIDDK · STANFORD UNIVERSITY · PI Seung K Kim · 2017 to 2026
$19.5M
Signature Protein Profiles to Identify AAAsP50HL083800 · NHLBI · STANFORD UNIVERSITY · PI DALMAN, RONALD L · 2006 to 2010
$13.7M
DNA Variants and AAA DiseaseR01HL101388 · NHLBI · STANFORD UNIVERSITY · PI TSAO, PHILIP S · 2010 to 2013
$1.6M
MicroRNA Regulation of Nicotine Accelerated AAAsR01HL122939 · NHLBI · PALO ALTO VETERANS INSTIT FOR RESEARCH · PI TSAO, PHILIP S · 2014 to 2017
$1.4M
Ultra high throughput sequencer for sustaining and enhancing multi-scale genomic studiesS10OD025212 · OD · STANFORD UNIVERSITY · PI SNYDER, MICHAEL P. · 2018 to 2018
$600k
NHGRI NIH HHS UM1 HG009442NHLBI NIH HHS P50 HL083800NHLBI NIH HHS R01 HL101388NHLBI NIH HHS R01 HL122939NIDDK NIH HHS P30 DK116074NIH HHS S10 OD025212Wellcome Trust
6 · The paper itself

Abstract

New therapeutic targets are a valuable resource in the struggle to reduce the morbidity and mortality associated with the COVID-19 pandemic, caused by the SARS-CoV-2 virus. Genome-wide association studies (GWAS) have identified risk loci, but some loci are associated with co-morbidities and are not specific to host-virus interactions. Here, we identify and experimentally validate a link between reduced expression of EXOSC2 and reduced SARS-CoV-2 replication. EXOSC2 was one of 332 host proteins examined, all of which interact directly with SARS-CoV-2 proteins; EXOSC2 interacts with Nsp8 which forms part of the viral RNA polymerase. Lung-specific eQTLs were identified from GTEx (v7) for each of the 332 host proteins. Aggregating COVID-19 GWAS statistics for gene-specific eQTLs revealed an association between increased expression of

Identifiers

PMID35291294
PMCPMC8923113
OpenAlexW4220652061

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.