Evidence map›Paper›PMID 35291019›Full record

ReviewTopics in current chemistry (Cham)2022

Evolution of the Automatic Rhodopsin Modeling (ARM) Protocol.

Laura Pedraza-González, Leonardo Barneschi, Daniele Padula, Luca De Vico, Massimo Olivucci

Abstract readReview
In one paragraph

Review in Topics in current chemistry (Cham), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Structural analysis of rhodopsin states in megabody complexes.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  2. Article
  3. The OpenMolcasJournal of chemical theory and computation · 2023
    Article
  4. Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Laura Pedraza-González *Dipartimento di Biotecnologie, Chimica e Farmacia, Università degli Studi di Siena, Via Aldo Moro 2, 53100, Siena, Italy. laura.pedraza@unisi.it.ORCID http://orcid.org/0000-0002-9806-236X
Leonardo BarneschiDipartimento di Biotecnologie, Chimica e Farmacia, Università degli Studi di Siena, Via Aldo Moro 2, 53100, Siena, Italy.ORCID http://orcid.org/0000-0003-0736-1696
Daniele PadulaDipartimento di Biotecnologie, Chimica e Farmacia, Università degli Studi di Siena, Via Aldo Moro 2, 53100, Siena, Italy.ORCID http://orcid.org/0000-0002-7171-7928
Luca De Vico *Dipartimento di Biotecnologie, Chimica e Farmacia, Università degli Studi di Siena, Via Aldo Moro 2, 53100, Siena, Italy. Luca.DeVico@unisi.it.ORCID http://orcid.org/0000-0002-2821-5711
Massimo Olivucci *Dipartimento di Biotecnologie, Chimica e Farmacia, Università degli Studi di Siena, Via Aldo Moro 2, 53100, Siena, Italy. olivucci@unisi.it.ORCID http://orcid.org/0000-0002-8247-209X

Funding

Computational Design of Highly Fluorescent RhodopsinsR15GM126627 · NIGMS · BOWLING GREEN STATE UNIVERSITY · PI OLIVUCCI, MASSIMO · 2018 to 2018
$337k
Ministero dell'Istruzione, dell'Università e della Ricerca Rita Levi Montalcini grant, 2021-2024National Science Foundation CHE-CLP-1710191NIGMS NIH HHS R15 GM126627NIH HHS 1R15GM126627 01
6 · The paper itself

Abstract

In recent years, photoactive proteins such as rhodopsins have become a common target for cutting-edge research in the field of optogenetics. Alongside wet-lab research, computational methods are also developing rapidly to provide the necessary tools to analyze and rationalize experimental results and, most of all, drive the design of novel systems. The Automatic Rhodopsin Modeling (ARM) protocol is focused on providing exactly the necessary computational tools to study rhodopsins, those being either natural or resulting from mutations. The code has evolved along the years to finally provide results that are reproducible by any user, accurate and reliable so as to replicate experimental trends. Furthermore, the code is efficient in terms of necessary computing resources and time, and scalable in terms of both number of concurrent calculations as well as features. In this review, we will show how the code underlying ARM achieved each of these properties.

Indexed as

RhodopsinRhodopsinPhotobiologyPhotochemistryPython packageQM/MMRhodopsins

Identifiers

PMID35291019
PMCPMC8924150

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.