Evidence map›Paper›PMID 35290819›Full record

Trial reportJournal of psychiatric research2022

Neural substrates of emotional conflict with anxiety in major depressive disorder: Findings from the Establishing Moderators and biosignatures of Antidepressant Response in Clinical Care (EMBARC) randomized controlled trial.

Joseph M Trombello, Crystal M Cooper, Cherise Chin Fatt, Bruce D Grannemann, Thomas J Carmody, Manish K Jha, Taryn L Mayes, Tracy L Greer, Uma Yezhuvath, Sina Aslan and 10 more

Open access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of psychiatric research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 6 citations in OpenAlex.

  1. Biomarker Methodologies: A NIMH Perspective.Advances in neurobiology · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 11 institutions in 1 country.

Joseph M TrombelloDepartment of Psychiatry, Center for Depression Research and Clinical Care, University of Texas Southwestern Medical Center, Dallas, TX, USA; Janssen Research & Development, LLC, Titusville, NJ, USA.
Crystal M CooperDepartment of Psychiatry, Center for Depression Research and Clinical Care, University of Texas Southwestern Medical Center, Dallas, TX, USA; Neuroscience Research, Cook Children's Medical Center, Fort Worth, TX, USA.
Cherise Chin FattDepartment of Psychiatry, Center for Depression Research and Clinical Care, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Bruce D GrannemannDepartment of Psychiatry, Center for Depression Research and Clinical Care, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Thomas J CarmodyDepartment of Psychiatry, Center for Depression Research and Clinical Care, University of Texas Southwestern Medical Center, Dallas, TX, USA; Department of Population and Data Sciences, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Manish K JhaDepartment of Psychiatry, Center for Depression Research and Clinical Care, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Taryn L MayesDepartment of Psychiatry, Center for Depression Research and Clinical Care, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Tracy L GreerDepartment of Psychiatry, Center for Depression Research and Clinical Care, University of Texas Southwestern Medical Center, Dallas, TX, USA; Department of Psychology, The University of Texas at Arlington, Arlington, TX, USA.
Uma YezhuvathAdvance MRI LLC, Frisco, TX, USA.
Sina AslanDepartment of Psychiatry, Center for Depression Research and Clinical Care, University of Texas Southwestern Medical Center, Dallas, TX, USA; Advance MRI LLC, Frisco, TX, USA.
Diego A PizzagalliHarvard Medical School, McLean Hospital, Department of Psychiatry, Boston, MA, USA.
Myrna M WeissmanColumbia University, Department of Psychiatry, New York, NY, USA; New York State Psychiatric Institute and Department of Psychiatry, College of Physicians and Surgeons of Columbia University, New York, NY, USA.
Christian A WebbHarvard Medical School, McLean Hospital, Department of Psychiatry, Boston, MA, USA.
Daniel G DillonHarvard Medical School, McLean Hospital, Department of Psychiatry, Boston, MA, USA.
Patrick J McGrathColumbia University, Department of Psychiatry, New York, NY, USA; New York State Psychiatric Institute and Department of Psychiatry, College of Physicians and Surgeons of Columbia University, New York, NY, USA.
Maurizio FavaMassachusetts General Hospital, Department of Psychiatry, Boston, MA, USA.
Ramin V ParseyStony Brook University, Department of Psychiatry, Stony Brook, NY, USA.
Melvin G McInnisUniversity of Michigan, Department of Psychiatry, Ann Arbor, MI, USA.
Amit EtkinStanford University School of Medicine, Department of Psychiatry, Palo Alto, CA, USA.
Madhukar H TrivediDepartment of Psychiatry, Center for Depression Research and Clinical Care, University of Texas Southwestern Medical Center, Dallas, TX, USA. Electronic address: madhukar.trivedi@utsouthwestern.edu.
The University of Texas Southwestern Medical Center · USHarvard University · USSouthwestern Medical Center · USColumbia University · USCook Children's Medical Center · USMagnetic Resonance Innovations (United States) · USMassachusetts General Hospital · USStanford University · USStony Brook University · USThe University of Texas at Arlington · USUniversity of Michigan · US

Funding

Establishing Moderators/Biosignatures of Antidepressant Response- Clinical CareU01MH092221 · NIMH · UT SOUTHWESTERN MEDICAL CENTER · PI TRIVEDI, MADHUKAR H. · 2010 to 2015
$9.7M
Biosignatures of Treatment Remission in Major DepressionU01MH092250 · NIMH · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MCGRATH, PATRICK J, PARSEY, RAMIN V. · 2010 to 2015
$8.9M
UT Southwestern Center for Translational MedicineKL2TR003981 · NCATS · UT SOUTHWESTERN MEDICAL CENTER · PI ARGENBRIGHT, KEITH EDWARD, TRIVEDI, MADHUKAR H. · 2021 to 2025
$5.9M
NCATS NIH HHS KL2 TR003981NIMH NIH HHS U01 MH092221NIMH NIH HHS U01 MH092250
6 · The paper itself

Abstract

backgroundThe brain circuitry of depression and anxiety/fear is well-established, involving regions such as the limbic system and prefrontal cortex. We expand prior literature by examining the extent to which four discrete factors of anxiety (immediate state anxiety, physiological/panic, neuroticism/worry, and agitation/restlessness) among depressed outpatients are associated with differential responses during reactivity to and regulation of emotional conflict.

methodsA total of 172 subjects diagnosed with major depressive disorder underwent functional magnetic resonance imaging while performing an Emotional Stroop Task. Two main contrasts were examined using whole brain voxel wise analyses: emotional reactivity and emotion regulation. We also evaluated the association of these contrasts with the four aforementioned anxiety factors.

resultsDuring emotional reactivity, participants with higher immediate state anxiety showed potentiated activation in the rolandic operculum and insula, while individuals with higher levels of physiological/panic demonstrated decreased activation in the posterior cingulate. No significant results emerged for any of the four factors on emotion regulation. When re-analyzing these statistically-significant brain regions through analyses of a subsample with (n = 92) and without (n = 80) a current anxiety disorder, no significant associations occurred among those without an anxiety disorder. Among those with an anxiety disorder, results were similar to the full sample, except the posterior cingulate was associated with the neuroticism/worry factor.

conclusionsDivergent patterns of task-related brain activation across four discrete anxiety factors could be used to inform treatment decisions and target specific aspects of anxiety that involve intrinsic processing to attenuate overactive responses to emotional stimuli.

Indexed as

Major Depressive DisorderAntidepressive AgentsAnxietyAnxiety DisordersBrainCalcium PhosphatesEmotionsHumansMagnetic Resonance ImagingAntidepressive AgentsCalcium PhosphatesEmbarcAnxietyDepressionEMBARCEmotionfMRIStroop

Identifiers

PMID35290819
PMCPMC9746288
OpenAlexW4220673572

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.