Evidence map›Paper›PMID 35290777›Full record

ArticleDevelopmental cell2022

Stepping on the molecular brake: Slowing down proliferation to allow differentiation.

Isabella Burda, Adrienne H K Roeder

Abstract readComment
PubMed Publisher
In one paragraph

Article in Developmental cell, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Molecular principles underlying aggressive cancers.Signal transduction and targeted therapy · 2025
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Isabella BurdaWeill Institute for Cell and Molecular Biology, Genetics, Genomics, and Development Graduate Field and School of Integrative Plant Science, Section of Plant Biology, Cornell University, Ithaca, NY 14853, USA.
Adrienne H K RoederWeill Institute for Cell and Molecular Biology, Genetics, Genomics, and Development Graduate Field and School of Integrative Plant Science, Section of Plant Biology, Cornell University, Ithaca, NY 14853, USA. Electronic address: ahr75@cornell.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cellular differentiation can entail changes to the cell cycle. In this issue of Developmental Cell, Han et al. show that the transcription factor MUTE directly activates expression of the cyclin-dependent kinase (CDK) inhibitor SIAMESE RELATED 4 (SMR4), thereby slowing down G1 during the transition to stomatal differentiation.

Indexed as

Cyclin-Dependent KinasesCyclinsCell CycleCell Cycle ProteinsCell DifferentiationCell DivisionCyclin-Dependent Kinase 2Cyclin-Dependent Kinase Inhibitor p21DecelerationG1 PhaseCell Cycle ProteinsCyclin-Dependent Kinase 2Cyclin-Dependent Kinase Inhibitor p21Cyclin-Dependent KinasesCyclins

Identifiers

PMID35290777

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.