ArticleBrain and behavior2022
The relationship between body mass index and postoperative delirium.
Article in Brain and behavior, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.
- Association of preoperative prognostic nutritional index with risk of postoperative delirium: A systematic review and meta-analysis.Frontiers in medicine · 2022Pooled it
- Validation of intraoperative processed electroencephalography and cerebral oximetry for prediction of postoperative delirium in cardiac surgery: a prospective observational study.Canadian journal of anaesthesia = Journal canadien d'anesthesie · 2026Observational
- Derivation and validation of a prediction rule for sedative-associated delirium during acute respiratory failure requiring mechanical ventilation.Journal of critical care · 2026Article
- Reply to the letter by Xiaonan Wang.Journal of anesthesia · 2026Article
- Intraoperative hypotension is associated with adverse postoperative clinical outcomes in elderly patients with hip fractures.Journal of orthopaedic surgery and research · 2026Article
- Nomogram for subsyndromal delirium after cardiac surgery with cardiopulmonary bypass: a retrospective cohort study.Frontiers in medicine · 2026Article
- Coronavirus disease 2019-related risk factors for postoperative delirium: a secondary analysis of an observational cohort study.International journal of surgery (London, England) · 2025Article
- Cervical myelopathy symptom severity, posterior-based cervical surgical approach, and lower body mass index are associated with postoperative delirium: A retrospective observational study.North American Spine Society journal · 2025Article
- Can Obesity Serve as a Barrier to Minimally Invasive Mitral Valve Surgery? Overcoming the Limitations-A Multivariate Logistic Regression Analysis.Journal of clinical medicine · 2024Article
- Association of preoperative frailty with risk of postoperative delirium in older patients undergoing craniotomy: a prospective cohort study.BMC surgery · 2024Article
- Exploring the role of calf circumference as a predisposing factor for intra-hospital delirium: investigating potential gender differences: revealing potential gender variances.BMC geriatrics · 2024Article
- Mesial temporal atrophy in preoperative MRI rather than steep Trendelenburg position is associated with postoperative delirium in patients undergoing a major urologic surgery.International urology and nephrology · 2024Article
- Study on the causal relationship between educational attainment and delirium: A two-sample Mendelian randomization study.Heliyon · 2024Article
- Article
- Opioid use and subsequent delirium risk in patients with advanced cancer in palliative care: a multicenter registry study.Scientific reports · 2024Article
- Relationship between preoperative neutrophil-to-lymphocyte ratio and postoperative delirium: The PNDABLE and the PNDRFAP cohort studies.Brain and behavior · 2023Article
- Factors associated with intensive care unit delirium in patients with acute myocardial infarction.Heart and vessels · 2023Article
- The relationship between body mass index and postoperative delirium.Brain and behavior · 2022Article
- Potential Value of Serum Uric Acid in the Identification of Postoperative Delirium in Geriatric Patients Undergoing Knee Replacement.Frontiers in aging neuroscience · 2022Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeWe aimed to investigate the relevance of body mass index (BMI) to postoperative delirium (POD), and to test whether the influences of BMI on POD were mediated by cerebrospinal fluid (CSF) biomarkers. PATIENTS AND
methodsOur study recruited 682 and 761 cognitively intact individuals from the perioperative neurocognitive disorder risk factor and prognosis (PNDRFAP) study and the perioperative neurocognitive disorder and biomarker lifestyle (PNDABLE) study, respectively. The incidence of POD was evaluated by using Confusion Assessment Method (CAM), and POD severity was measured by using the Memorial Delirium Assessment Scale (MDAS). Logistic regression was used to analyze the relationship between BMI and POD. The levels of Aβ40, Aβ42, T-tau, and P-tau in preoperative CSF were measured by enzyme-linked immune-sorbent assay (ELISA) in the PNDABLE study. Mediation analysis with 5000 bootstrapped iterations was used to explore the mediation effects.
resultsIn the PNDRFAP study, the incidence of POD was 16.3%, with logistic regression analysis showing that BMI (odds ratio [OR] = 0.900, 95% confidence interval [CI] 0.823-0.985, p = .022) is a protective factor of POD. In the PNDABLE study, the incidence of POD was 18.7%, and regression analysis confirmed that BMI (OR = 0.832, 95% CI 0.761-0.910, p < .001) is a protective factor of POD, while T-tau (OR = 1.005, 95% CI 1.003-1.006, p < .001) and P-tau (OR = 1.037, 95% CI 1.024-1.050, p < .001) were risk factors of POD. Mediation analyses revealed that the association between BMI and POD was partially mediated by T-tau (proportion: 36%) and P-tau (proportion: 24%).
conclusionHigher BMI mediated protective effects on POD through CSF biomarkers (T-tau and P-tau).
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