ArticleCNS neuroscience & therapeutics2022
Effect of stress-induced hyperglycemia after non-traumatic non-aneurysmal subarachnoid hemorrhage on clinical complications and functional outcomes.
Article in CNS neuroscience & therapeutics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Predictive value of stress-induced hyperglycemia for 28-day all-cause mortality in ICU patients with sepsis: a MIMIC-IV-based retrospective cohort study.Clinics (Sao Paulo, Brazil) · 2026Article
- Non-Aneurysmal Subarachnoid Hemorrhage in a Patient With Type 1 Diabetes Mellitus: A Case Report.Cureus · 2026Article
- Group-based trajectory modeling identifies distinct glycemic patterns predictive of mortality in aneurysmal subarachnoid hemorrhage.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025Article
- Association of the stress hyperglycemia ratio for all-cause and cardiovascular mortality in population with cardiovascular-kidney-metabolic syndrome stages 0-4: evidence from a large cohort study.Diabetology & metabolic syndrome · 2025Article
- Development and external validation of a nomogram for predicting one-year survival in patients with non-traumatic subarachnoid hemorrhage.Frontiers in surgery · 2025Article
- A superior tool for predicting sepsis in SAH patients: The nomogram outperforms SOFA score.PloS one · 2025Article
- Effect of cortisol and glycosylated-hemoglobin levels on mortality in intensive care unit.Saudi medical journal · 2024Article
- Low serum magnesium is associated with poor functional outcome in acute ischemic stroke or transient ischemic attack patients.CNS neuroscience & therapeutics · 2023Article
- Exploration of Risk Factors for Poor Prognosis of Non-Traumatic Non-Aneurysmal Subarachnoid Hemorrhage.Biomolecules · 2022Article
- Effect of stress-induced hyperglycemia after non-traumatic non-aneurysmal subarachnoid hemorrhage on clinical complications and functional outcomes.CNS neuroscience & therapeutics · 2022Article
- A predictive model using risk factor categories for hospital-acquired pneumonia in patients with aneurysmal subarachnoid hemorrhage.Frontiers in neurology · 2022Article
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Authors and funding
10 authors.
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Abstract
backgroundDespite having an overall benign course, non-traumatic non-aneurysmal subarachnoid hemorrhage (naSAH) is still accompanied by a risk of clinical complications and poor outcomes. Risk factors and mechanisms of complications and poor outcomes after naSAH remain unknown. Our aim was to explore the effect of stress-induced hyperglycemia (SIH) on complication rates and functional outcomes in naSAH patients.
methodsWe retrospectively reviewed patients with naSAH admitted to our institution between 2013 and 2018. SIH was identified according to previous criterion. Symptomatic vasospasm, delayed cerebral infarction, and hydrocephalus were identified as main complications. Outcomes were reviewed using a modified Rankin Scale (mRS) at discharge, 3 months, and 12 months. A statistical analysis was conducted to reveal the associations of SIH with complications and outcomes.
resultsA total of 244 naSAH patients were included in the cohort with 74 (30.3%) SIH. After adjusting for age, gender, hypertension, Hunt and Hess (HH) grade, modified Fisher Scale (mFS), intraventricular hemorrhage (IVH), and subarachnoid blood distribution, SIH was significantly associated with symptomatic vasospasm (p < 0.001, 12.176 [4.904-30.231]), delayed cerebral infarction (p < 0.001, 12.434 [3.850-40.161]), hydrocephalus (p = 0.008, 5.771 [1.570-21.222]), and poor outcome at 12 months (p = 0.006, 5.506 [1.632-18.581]), whereas the correlation between SIH and poor outcome at discharge (p = 0.064, 2.409 [0.951-6.100]) or 3 months (p = 0.110, 2.029 [0.852-4.833]) was not significant. Incorporation of SIH increased the area under curve (AUC) of ROC in the combined model for predicting symptomatic vasospasm (p = 0.002), delayed cerebral infarction (p = 0.024), hydrocephalus (p = 0.037), and 12-month poor outcome (p = 0.087).
conclusionsSIH is a significant and independent risk factor for symptomatic vasospasm, delayed cerebral infarction, hydrocephalus, and long-term poor outcome in naSAH patients. Identifying SIH early after naSAH is important for decision-making and treatment planning.
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