Evidence map›Paper›PMID 35290634›Full record

ArticleMethods in molecular biology (Clifton, N.J.)2022

Approaches to Monitor Termination of DNA Replication Using Xenopus Egg Extracts.

Tamar Kavlashvili, James M Dewar

Erratum issuedAbstract read
PubMed Publisher
In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Tamar KavlashviliDepartment of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN, USA.
James M DewarDepartment of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN, USA. James.Dewar@vanderbilt.edu.

Funding

Mechanisms that ensure the completion of DNA synthesisR35GM128696 · NIGMS · VANDERBILT UNIVERSITY · PI James M Dewar · 2018 to 2026
$4.0M
NIGMS NIH HHS R35 GM128696
6 · The paper itself

Abstract

DNA replication is crucial for cell viability and genome integrity. Despite its crucial role in genome duplication, the final stage of DNA replication, which is termed termination, is relatively unexplored. Our knowledge of termination is limited by cellular approaches to study DNA replication, which cannot readily detect termination. In contrast, the Xenopus laevis egg extract system allows for all of DNA replication to be readily detected. Here we describe the use of this system and assays to monitor replication termination.

Indexed as

DNA ReplicationOocytesAnimalsGenomeXenopus laevisChromatin captureDecatenationDNA replicationDNA synthesisFork mergerLigationXenopus egg extracts

Identifiers

PMID35290634

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.