ArticleInfection2022
Surgery and outcome of infective endocarditis in octogenarians: prospective data from the ESC EORP EURO-ENDO registry.
Article in Infection, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 32 citations in OpenAlex.
- Long-term Oral Suppressive Antimicrobial Therapy in Infective Endocarditis (SATIE Study): An Observational Study.Open forum infectious diseases · 2024Trial
- The geriatric syndromes in elderly patients with infective endocarditis: impact on in-hospital mortality.Journal of geriatric cardiology : JGC · 2026Article
- Specialty-Related Differences in Adherence to Antibiotic Therapy Guidelines for Infective Endocarditis in Older Patients.Antibiotics (Basel, Switzerland) · 2026Article
- Cardiac valve prosthesis choice for left-sided infective endocarditis in Medicare patients.JTCVS open · 2026Article
- Prediction Scores Identifying Patients at High Risk of Endocarditis in Enterococcal Bacteremia.Open forum infectious diseases · 2026Article
- Infective endocarditis: it takes a team.European heart journal · 2025Review
- Epidemiological, clinical and microbiological aspects of infective endocarditis in Türkiye.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2025Article
- Clinical characteristics and outcomes of aortic prosthetic valve endocarditis: comparison between transcatheter and surgical bioprostheses.Infection · 2024Article
- Unexpected Infective Endocarditis: Towards a New Alert for Clinicians.Journal of clinical medicine · 2024Review
- Dalbavancin as consolidation therapy for infective endocarditis in patients with comorbidity. A real world experience.Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia · 2024Observational
- Perioperative risk stratification scores in infective endocarditis and its usefulness.Indian journal of thoracic and cardiovascular surgery · 2024Review
- Cardiac device-related infective endocarditis need for lead extraction whatever the device according to the ESC EORP EURO-ENDO registry.European heart journal open · 2023Article
- The Role of Platelets in Infective Endocarditis.International journal of molecular sciences · 2023Review
- Clinical Presentation and Risk Factors of Infective Endocarditis in the Elderly: A Systematic Review.Journal of personalized medicine · 2023Review
- Taming the beast: are multidisciplinary Endocarditis Teams enough?Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation · 2023Article
- Comorbidity and Prognosis in Octogenarians with Infective Endocarditis.Journal of clinical medicine · 2022Article
Corrections and comments
- Erratum issued
Authors and funding
20 authors at 18 institutions in 11 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeHigh mortality and a limited performance of valvular surgery are typical features of infective endocarditis (IE) in octogenarians, even though surgical treatment is a major determinant of a successful outcome in IE.
methodsData from the prospective multicentre ESC EORP EURO-ENDO registry were used to assess the prognostic role of valvular surgery depending on age.
resultsAs compared to < 80 yo patients, ≥ 80 yo had lower rates of theoretical indication for valvular surgery (49.1% vs. 60.3%, p < 0.001), of surgery performed (37.0% vs. 75.5%, p < 0.001), and a higher in-hospital (25.9% vs. 15.8%, p < 0.001) and 1-year mortality (41.3% vs. 22.2%, p < 0.001). By multivariable analysis, age per se was not predictive of 1-year mortality, but lack of surgical procedures when indicated was strongly predictive (HR 2.98 [2.43-3.66]). By propensity analysis, 304 ≥ 80 yo were matched to 608 < 80 yo patients. Propensity analysis confirmed the lower rate of indication for valvular surgery (51.3% vs. 57.2%, p = 0.031) and of surgery performed (35.3% vs. 68.4%, p < 0.0001) in ≥ 80 yo. Overall mortality remained higher in ≥ 80 yo (in-hospital: HR 1.50[1.06-2.13], p = 0.0210; 1-yr: HR 1.58[1.21-2.05], p = 0.0006), but was not different from that of < 80 yo among those who had surgery (in-hospital: 19.7% vs. 20.0%, p = 0.4236; 1-year: 27.3% vs. 25.5%, p = 0.7176).
conclusionAlthough mortality rates are consistently higher in ≥ 80 yo patients than in < 80 yo patients in the general population, mortality of surgery in ≥ 80 yo is similar to < 80 yo after matching patients. These results confirm the importance of a better recognition of surgical indication and of an increased performance of surgery in ≥ 80 yo patients.
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