ArticleJournal of echocardiography2022
Novel regional longitudinal strain by speckle tracking to detect significant coronary artery disease in patients admitted to the emergency department for chest pain suggestive of acute coronary syndrome.
Article in Journal of echocardiography, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed.
- Anterior papillary muscle strain predicts significant left anterior descending coronary artery stenosis in patients undergoing angiography.Scientific reports · 2026Observational
- Association of long-term exposure to air pollution with the risk of new-onset pain among middle-aged and older people: a cohort study in China.Clinical rheumatology · 2026Article
- Predictive value of combined electrocardiographic and echocardiographic parameters for major adverse cardiovascular events in patients with established coronary artery disease: a single-center retrospective cohort study.Frontiers in medicine · 2026Article
- Correlation between CT-derived fractional flow reserve and myocardial strain in ischemic heart disease patients with single coronary artery stenosis assessed based on CCTA.Frontiers in cardiovascular medicine · 2025Article
- Acute global longitudinal strain evaluation in patients with subacute to chronic chest pain: A pilot, observational study.American heart journal plus : cardiology research and practice · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundGlobal longitudinal strain has shown variable results in detecting ischemia in patients admitted to the emergency department with chest pain, but without other clear evidence of coronary artery disease (CAD). Our aim was to investigate whether assessment of regional longitudinal myocardial function could assist in detecting significant CAD in these patients.
methodsClinical evaluation, electrocardiogram, echocardiogram and troponin T were evaluated in 126 patients admitted with chest pain. A subsequent invasive coronary angiography divided patients into two groups: significant CAD (CAD+) or non-significant CAD (CAD-). Global and regional myocardial function were evaluated by speckle tracking echocardiography. Regional longitudinal strain was defined as the highest longitudinal strain values in four adjacent left ventricular segments and termed 4AS.
resultsCAD+ was found in 37 patients (29%) of which 51% had elevated troponin. Mean 4AS was - 13.1% (± 3.5) in the CAD+ and - 15.2% (± 2.7) (p = 0.002) in the CAD- group. Predictors for CAD+ were age [OR 1.06 (1.01-1.11, p = 0.026)], smoking [OR 3.39 (1.21-9.51, p = 0.020)], troponin [OR 3.32 (1.28-8.60, p = 0.014)) and 4AS (OR 1.24 (1.05-1.46, p = 0.010)]. A cutoff for 4AS of > - 15% showed the best diagnostic performance with event-reclassification of 0.41 (p < 0.001), non-event-reclassification of - 0.34 (p < 0.001) and net reclassification improvement 0.07 (p = 0.60).
conclusionDecreased myocardial function in four adjacent LV segments assessed by strain has the potential to detect significant CAD in patients admitted with chest pain and negative/slightly elevated initial troponin.
trial registrationCurrent Research information system in Norway (CRISTIN). Id: 555249.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.