ArticleInternational journal of colorectal disease2022
The impact of low serum cholinesterase levels on survival in patients with colorectal cancer.
Article in International journal of colorectal disease, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 26 citations in OpenAlex.
- Key Biomarker Correlations in Cutaneous Melanoma: Implications for Diagnostic, Prognostic, and Therapeutic Strategies-A Retrospective Single-Centered Study.Medicina (Kaunas, Lithuania) · 2025Article
- Longitudinal evaluation of serum cholinesterase benefits prognosis surveillance of common types of human cancer.Communications medicine · 2025Article
- Measurement of acetylcholinesterase activity by electrochemical analysis method utilizing organocatalytic reactions.RSC advances · 2025Article
- Serum cholinesterase combined with platelet-to-hemoglobin ratio for predicting survival prognosis in stage I-III colorectal cancer patients undergoing radical surgery: a retrospective cohort study.BMC gastroenterology · 2025Article
- Albumin-Butyrylcholinesterase as a Novel Prognostic Biomarker for Hepatocellular Carcinoma Post-hepatectomy: A Retrospective Cohort Study with the Hiroshima Surgical Study Group of Clinical Oncology.Annals of surgical oncology · 2025Article
- Low Serum Cholinesterase Levels Predict Poor Prognosis in Patients with Ovarian Cancer.International journal of general medicine · 2025Article
- The association between preoperative serum cholinesterase and all-cause mortality in geriatric patients with hip fractures: a cohort study of 2387 patients.Perioperative medicine (London, England) · 2024Article
- Preoperative serum cholinesterase as a prognostic factor in patients with colorectal cancer.Annals of gastroenterological surgery · 2024Article
- Serum Cholinesterase, C-reactive Protein, Interleukin 6, and Procalcitonin Levels as Predictors of Mortality in Patients in the Intensive Care Unit.Turkish journal of anaesthesiology and reanimation · 2023Article
- The influence of serum cholinesterase levels and sarcopenia on postoperative infectious complications in colorectal cancer surgery.Surgery today · 2023Article
- Prognostic significance of osteosarcopenia in older adults with colorectal cancer.Annals of gastroenterological surgery · 2023Article
- The impact of sarcobesity on incisional hernia after laparoscopic colorectal cancer surgery.International journal of colorectal disease · 2023Article
- Analysis of risk factors of low cardiac output syndrome after pericardiectomy for tuberculous constrictive pericarditis: A retrospective study.Indian heart journalArticle
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeNutritional and inflammatory status have been associated with postoperative recurrence and poor survival in patients with colorectal cancer. The aim of the present study is to investigate the relationship between serum cholinesterase levels and postoperative outcomes among patients who underwent curative resection for colorectal cancer.
methodsThe study comprised 174 patients who had undergone curative resection for colorectal cancer. We explored the relationship between preoperative serum cholinesterase levels and disease-free survival and overall survival after curative resection. Then patients were divided into the high-cholinesterase group (n = 102) and the low-cholinesterase group (n = 72) to analyze their clinicopathological variables including other nutritional markers and systemic inflammatory responses.
resultsIn multivariate analysis, lymph node metastasis (P = 0.011) and serum cholinesterase levels (P < 0.01) were independent predictors of disease-free survival, while lymph node metastasis (P = 0.013), serum cholinesterase levels (P < 0.01), and carbohydrate antigen19-9 (P = 0.022) were independent predictors of overall survival. In the low-cholinesterase group, neutrophil to lymphocyte ratio, (P = 0.021), C-reactive protein to albumin ratio (P < 0.01), and distant metastasis (P < 0.01) were higher, and prognostic nutritional index (P < 0.01) was lower compared with the high-cholinesterase group.
conclusionPreoperative low serum cholinesterase levels can be a prognostic factor for postoperative recurrence and poor prognosis in patients after curative resection for colorectal cancer, suggesting an important role of cholinesterase in the assessment of nutritional and inflammatory status in cancer patients.
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