Evidence map›Paper›PMID 35290480›Full record

ArticleEuropean journal of clinical pharmacology2022

Systemic quinolones and risk of retinal detachment III: a nested case-control study using a US electronic health records database.

Mohamed Kadry Taher, James A G Crispo, Yannick Fortin, Ryan Moog, Douglas McNair, Lise M Bjerre, Franco Momoli, Donald Mattison, Daniel Krewski

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of clinical pharmacology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.9field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Safety of fluoroquinolones.Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia · 2024
    Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Mohamed Kadry TaherMcLaughlin Centre for Population Health Risk Assessment, Faculty of Medicine, University of Ottawa, Room 216, 600 Peter Morand Crescent, Ottawa, ON, K1G 5Z3, Canada. Mohamed.Taher@uOttawa.ca.ORCID http://orcid.org/0000-0002-5754-7512
James A G CrispoMcLaughlin Centre for Population Health Risk Assessment, Faculty of Medicine, University of Ottawa, Room 216, 600 Peter Morand Crescent, Ottawa, ON, K1G 5Z3, Canada.
Yannick FortinMcLaughlin Centre for Population Health Risk Assessment, Faculty of Medicine, University of Ottawa, Room 216, 600 Peter Morand Crescent, Ottawa, ON, K1G 5Z3, Canada.
Ryan MoogCerner Corporation, Kansas City, MO, USA.
Douglas McNairMelinda Gates Foundation, Seattle, WA, USA.
Lise M BjerreSchool of Epidemiology and Public Health, University of Ottawa, Ottawa, ON, Canada.
Franco MomoliSchool of Epidemiology and Public Health, University of Ottawa, Ottawa, ON, Canada.
Donald MattisonMcLaughlin Centre for Population Health Risk Assessment, Faculty of Medicine, University of Ottawa, Room 216, 600 Peter Morand Crescent, Ottawa, ON, K1G 5Z3, Canada.
Daniel KrewskiMcLaughlin Centre for Population Health Risk Assessment, Faculty of Medicine, University of Ottawa, Room 216, 600 Peter Morand Crescent, Ottawa, ON, K1G 5Z3, Canada.
University of Ottawa · CACerner (United States) · USGates Foundation · USStatistics Canada · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundQuinolones are popular antibiotics that are known for their potency, broad coverage, and reasonable safety. Concerns have been raised about a possible association between quinolones and retinal detachment (RD).

methodsWe conducted a nested case-control study using electronic health records (EHR) from the Health Facts® Database. The initial cohort included all patients who were admitted between 2000 and 2016, with no history of eye disease, and had a minimum medical history of one year. Eligible cases comprised inpatients who were first admitted with a primary diagnosis of RD between 2010 and 2015. Each eligible case was matched without replacement to five unique controls by sex, race, age, and period-at-risk. We used conditional logistic regression to calculate RD risk, adjusting for exposure to other medications, and major risk factors.

resultsWe identified 772 cases and 3860 controls. Whereas our primary analysis of all subjects revealed no quinolone-associated RD risk, elevated but non-significant risks were noted in African Americans (ciprofloxacin and levofloxacin), those aged 56-70 years old (moxifloxacin), and women (ciprofloxacin).

conclusionOur study did not identify an elevated RD risk within 30 days following systemic administration of quinolone antibiotics. Suggestions of increased risk observed in some population subgroups warrant further investigation.

Indexed as

QuinolonesRetinal DetachmentAgedAnti-Bacterial AgentsCase-Control StudiesCiprofloxacinElectronic Health RecordsFemaleHumansMiddle AgedAnti-Bacterial AgentsCiprofloxacinQuinolonesDrug safetyElectronic health recordsNested case–control studyPharmacovigilanceQuinolonesRetinal detachment

Identifiers

PMID35290480
PMCPMC9107393
OpenAlexW4221096369

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.