ArticleOptics letters2022
Multimodal imaging system combining optical coherence tomography and Brillouin microscopy for neural tube imaging.
Article in Optics letters, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Off-Axis Illumination and Epicollection Confocal Brillouin Scattering Microspectroscopy.Analytical chemistry · 2026Article
- Discovering the unexpected: Insights into the dynamics of mouse neural tube closure revealed by time-lapse imaging.Developmental biology · 2026Review
- Clinical multimodal Brillouin microscopy-optical coherence elastography system for lens biomechanics.Journal of biomedical optics · 2025Article
- A Survey on Optical Coherence Tomography-Technology and Application.Bioengineering (Basel, Switzerland) · 2025Review
- Dual optical elastography detectsJournal of biomedical optics · 2024Article
- Review
- Optical coherence tomography-guided Brillouin microscopy highlights regional tissue stiffness differences during anterior neural tube closure in the Mthfd1l murine mutant.Development (Cambridge, England) · 2024Article
- In vivo measurement of the biomechanical properties of human skin with motion-corrected Brillouin microscopy.Biomedical optics express · 2024Article
- Brillouin microscopy.Nature reviews. Methods primers · 2024Article
- Optical coherence elastography measures the biomechanical properties of theJournal of biomedical optics · 2024Article
- Photoacoustic elasto-viscography and optical coherence microscopy for multi-parametricBiomedical optics express · 2023Article
- Time-lapse mechanical imaging of neural tube closure in live embryo using Brillouin microscopy.Scientific reports · 2023Article
- Multiple Optical Elastography Techniques Reveal the Regulation of Corneal Stiffness by Collagen XII.Investigative ophthalmology & visual science · 2022Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
To understand the dynamics of tissue stiffness during neural tube formation and closure in a murine model, we have developed a multimodal, coaligned imaging system combining optical coherence tomography (OCT) and Brillouin microscopy. Brillouin microscopy can map the longitudinal modulus of tissue but cannot provide structural images. Thus, it is limited for imaging dynamic processes such as neural tube formation and closure. To overcome this limitation, we have combined Brillouin microscopy and OCT in one coaligned instrument. OCT provided depth-resolved structural imaging with a micrometer-scale spatial resolution to guide stiffness mapping by Brillouin modality. 2D structural and Brillouin frequency shift maps were acquired of mouse embryos at gestational day (GD) 8.5, 9.5, and 10.5 with the multimodal system. The results demonstrate the capability of the system to obtain structural and stiffness information simultaneously.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.