Evidence map›Paper›PMID 35290075›Full record

ArticleCirculation. Cardiovascular imaging2022

Heritability of Coronary Artery Disease: Insights From a Classical Twin Study.

Zsofia D Drobni, Marton Kolossvary, Julia Karady, Adam L Jermendy, Adam D Tarnoki, David L Tarnoki, Judit Simon, Balint Szilveszter, Levente Littvay, Szilard Voros and 3 more

Registry-linked trialAbstract readTwin Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Circulation. Cardiovascular imaging, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01738828 (Genetic Loci and the Burden of Atherosclerotic Lesions), which is not on this map. Cited by 36 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01738828 unknown statusnot on this map

Genetic Loci and the Burden of Atherosclerotic Lesions

TypeobservationalSponsorGlobal Genomics Group, LLCRan2012 to 2016Enrolled10,000ConditionsCoronary Artery Disease
3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 1 synthesis or guideline pooled it.

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  20. Advantageous early-life environments cushion the genetic risk for ischemic heart disease.Proceedings of the National Academy of Sciences of the United States of America · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Zsofia D DrobniMTA-SE Cardiovascular Imaging Research Group, (Z.D.D., M.K., J.K., A.L.J., J.S., B.S., P.M.-H.), Semmelweis University, Budapest, Hungary.ORCID 0000-0002-1355-5318
Marton KolossvaryCardiovascular Imaging Research Center, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA (M.K., J.K.).ORCID 0000-0002-5570-991X
Julia KaradyCardiovascular Imaging Research Center, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA (M.K., J.K.).ORCID 0000-0002-6640-6260
Adam L JermendyMTA-SE Cardiovascular Imaging Research Group, (Z.D.D., M.K., J.K., A.L.J., J.S., B.S., P.M.-H.), Semmelweis University, Budapest, Hungary.
Adam D TarnokiDepartment of Radiology, Medical Imaging Centre (A.D.T., D.L.T., P.M.-H.), Semmelweis University, Budapest, Hungary.
David L TarnokiDepartment of Radiology, Medical Imaging Centre (A.D.T., D.L.T., P.M.-H.), Semmelweis University, Budapest, Hungary.
Judit SimonMTA-SE Cardiovascular Imaging Research Group, (Z.D.D., M.K., J.K., A.L.J., J.S., B.S., P.M.-H.), Semmelweis University, Budapest, Hungary.ORCID 0000-0001-8063-3462
Balint SzilveszterMTA-SE Cardiovascular Imaging Research Group, (Z.D.D., M.K., J.K., A.L.J., J.S., B.S., P.M.-H.), Semmelweis University, Budapest, Hungary.
Levente LittvayDepartment of Political Science, Central European University, Budapest, Hungary (L.L.).ORCID 0000-0003-2022-6886
Szilard VorosGlobal Genomics Group, Richmond, VA (S.V.).
Gyorgy JermendyBajcsy-Zsilinszky Hospital, Budapest, Hungary (G.J.).
Bela MerkelyHeart and Vascular Center (B.M.), Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.ORCID 0000-0001-6514-0723
Pal Maurovich-HorvatDepartment of Radiology, Medical Imaging Centre (A.D.T., D.L.T., P.M.-H.), Semmelweis University, Budapest, Hungary.ORCID 0000-0003-0885-736X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundGenetics have a strong influence on calcified atherosclerotic plaques; however, data regarding the heritability of noncalcified plaque volume are scarce. We aimed to evaluate genetic versus environmental influences on calcium (coronary artery calcification) score, noncalcified and calcified plaque volumes by coronary computed tomography angiography in adult twin pairs without known coronary artery disease.

methodsIn the prospective BUDAPEST-GLOBAL (Burden of Atherosclerotic Plaques Study in Twins-Genetic Loci and the Burden of Atherosclerotic Lesions) classical twin study, we analyzed twin pairs without known coronary artery disease. All twins underwent coronary computed tomography angiography to assess coronary atherosclerotic plaque volumes. Structural equation models were used to quantify the contribution of additive genetic, common environmental, and unique environmental components to plaque volumes adjusted for age, gender, or atherosclerotic cardiovascular disease risk estimate and statin use.

resultsWe included 196 twins (mean age±SD, 56±9 years, 63.3% females), 120 monozygotic and 76 same-gender dizygotic pairs. Using structural equation models, noncalcified plaque volume was predominantly determined by environmental factors (common environment, 63% [95% CI, 56%-67%], unique environment, 37% [95% CI, 33%-44%]), while coronary artery calcification score and calcified plaque volumes had a relatively strong genetic heritability (additive genetic, 58% [95% CI, 50%-66%]; unique environmental, 42% [95% CI, 34%-50%] and additive genetic, 78% [95% CI, 73%-80%]; unique environmental, 22% [95% CI, 20%-27%]), respectively.

conclusionsNoncalcified plaque volume is mainly influenced by shared environmental factors, whereas coronary artery calcification score and calcified plaque volume are more determined by genetics. These findings emphasize the importance of early lifestyle interventions in preventing coronary plaque formation. REGISTRATION: URL: https://www. CLINICALTRIALS: gov; Unique identifier: NCT01738828.

Indexed as

AtherosclerosisCoronary Artery DiseasePlaque, AtheroscleroticAdultAgedComputed Tomography AngiographyCoronary AngiographyCoronary VesselsFemaleHumansMaleMiddle AgedProspective StudiesRisk Factorsatherosclerosiscomputed tomography angiographycoronary angiographycoronary artery diseaseprevalence

Identifiers

PMID35290075
PMCPMC8925867

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.