Evidence map›Paper›PMID 35290044›Full record

ArticleJournal of natural products2022

Marine Natural Products as Leads against SARS-CoV-2 Infection.

Bhuwan Khatri Chhetri, Philip R Tedbury, Anne Marie Sweeney-Jones, Luke Mani, Katy Soapi, Candela Manfredi, Eric Sorscher, Stefan G Sarafianos, Julia Kubanek

Abstract read
In one paragraph

Article in Journal of natural products, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Mechanisms by which the cystic fibrosis transmembrane conductance regulator may influence SARS-CoV-2 infection and COVID-19 disease severity.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2023
    Article
  3. GenusMarine drugs · 2023
    Review
  4. Review
  5. Review
  6. Article
  7. Article
  8. Catalysis-Enabled 13-Step Total Synthesis of (-)-Peyssonnoside A.Journal of the American Chemical Society · 2022
    Article
  9. Article
  10. Bioactive natural products in COVID-19 therapy.Frontiers in pharmacology · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Bhuwan Khatri ChhetriSchool of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, Georgia 30332, United States.
Philip R TedburyLaboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia 30322, United States.
Anne Marie Sweeney-JonesSchool of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, Georgia 30332, United States.
Luke ManiInstitute of Applied Sciences, University of South Pacific, Suva, Fiji.
Katy SoapiInstitute of Applied Sciences, University of South Pacific, Suva, Fiji.
Candela ManfrediDepartment of Pediatrics, Division of Pulmonary Medicine, Emory University School of Medicine, Atlanta, Georgia 30322, United States.
Eric SorscherDepartment of Pediatrics, Division of Pulmonary Medicine, Emory University School of Medicine, Atlanta, Georgia 30322, United States.
Stefan G SarafianosLaboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia 30322, United States.ORCID 0000-0002-5840-154X
Julia KubanekSchool of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, Georgia 30332, United States.ORCID 0000-0003-4482-1831

Funding

The USP Center for Drug Discovery and ConservationU19TW007401 · FIC · GEORGIA INSTITUTE OF TECHNOLOGY · PI HAY, MARK E · 2014 to 2018
$5.3M
FIC NIH HHS U19 TW007401
6 · The paper itself

Abstract

Since early 2020, disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become a global pandemic, causing millions of infections and deaths worldwide. Despite rapid deployment of effective vaccines, it is apparent that the global community lacks multipronged interventions to combat viral infection and disease. A major limitation is the paucity of antiviral drug options representing diverse molecular scaffolds and mechanisms of action. Here we report the antiviral activities of three distinct marine natural products─homofascaplysin A (

Indexed as

Biological ProductsCOVID-19 Drug TreatmentAntiviral AgentsEpithelial CellsHumansSARS-CoV-2Antiviral AgentsBiological Products

Identifiers

PMID35290044
PMCPMC8936055

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.