ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2023
Regional cerebral hypometabolism on 18F-FDG PET/CT scan in delirium is independent of acute illness and dementia.
Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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Who cites it
25 citing papers in PubMed, 41 citations in OpenAlex.
- Long-acting intranasal insulin for the treatment of delirium-a randomised clinical trial.Age and ageing · 2025Trial
- Intranasal Insulin Diminishes Postoperative Delirium and Elevated Osteocalcin and Brain Derived Neurotrophic Factor in Older Patients Undergoing Joint Replacement: A Randomized, Double-Blind, Placebo-Controlled Trial.Drug design, development and therapy · 2025Trial
- Regional cerebral hypometabolism and pathological heterogeneity in sporadic early onset alzheimer's disease: China Aging and Neurodegenerative Initiative (CANDI) study.European journal of nuclear medicine and molecular imaging · 2026Article
- Ketone bodies mitigate against systemic inflammation-induced changes in brain energy metabolism and delirium-like deficits in aged mice.bioRxiv : the preprint server for biology · 2026Article
- Magnetic resonance spectroscopy in hospitalised older people shows age and delirium-specific metabolic changes.Age and ageing · 2026Article
- [European journal of nuclear medicine and molecular imaging · 2026Article
- Cerebral metabolic covariance in delirium: pattern response to symptomatic changes.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Potential therapeutic benefit of exogenous ketone ester administration in delirium: a narrative review.Critical care (London, England) · 2025Review
- Observational
- The intersection of delirium and long-term cognition in older adults: the critical role of delirium prevention.Journal of neurology · 2025Review
- Predilection for Perplexion: Preoperative microstructural damage is linked to postoperative delirium.medRxiv : the preprint server for health sciences · 2025Article
- The Relationship between Delirium and Dementia.Seminars in neurology · 2024Review
- Efficacy and safety of guanfacine in hospitalized patients with delirium: A scoping review.Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine · 2024Article
- The Pathophysiology and Biomarkers of Delirium.Seminars in neurology · 2024Review
- Association between preoperative persistent hyperglycemia and postoperative delirium in geriatric hip fracture patients.BMC geriatrics · 2024Article
- Diffuse optical tomography for mapping cerebral hemodynamics and functional connectivity in delirium.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Association BetweenNuclear medicine and molecular imaging · 2024Article
- Structural disconnectivity in postoperative delirium: A perioperative two-center cohort study in older patients.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- A Molecular Framework for Delirium.The Neurohospitalist · 2024Review
- Impaired glucose utilization in the brain of patients with delirium following hip fracture.Brain : a journal of neurology · 2024Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionDelirium is associated with new onset dementia and accelerated cognitive decline; however, its pathophysiology remains unknown. Cerebral glucose metabolism previously seen in delirium may have been attributable to acute illness and/or dementia. We aimed to statistically map cerebral glucose metabolism attributable to delirium.
methodsWe assessed cerebral glucose metabolism using
resultsPatients with delirium demonstrated hypometabolism in the bilateral thalami and right superior frontal, right posterior cingulate, right infero-lateral anterior temporal, and left superior parietal cortices. Regional hypometabolism correlated with delirium severity and performance on neuropsychological testing. DISCUSSION: In patients with acute illness but without clinical dementia, delirium is accompanied by regional cerebral hypometabolism. While some hypometabolic regions may represent preclinical Alzheimer's disease (AD), thalamic hypometabolism is atypical of AD and consistent with the clinical features that are unique to delirium.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.