Evidence map›Paper›PMID 35289956›Full record

Observational studyJournal of orthopaedic research : official publication of the Orthopaedic Research Society2023

Characterizing tourniquet induced hemodynamics during total knee arthroplasty using diffuse optical spectroscopy.

George P Philipopoulos, Behnam Sharareh, Goutham Ganesan, Bruce J Tromberg, Thomas D O'Sullivan, Ran Schwarzkopf

Open access · bronzeAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

George P PhilipopoulosBeckman Laser Institute and Medical Clinic, Laser Microbeam and Medical Program, University of California Irvine, Irvine, California, USA.
Behnam ShararehDepartment of Orthopaedics and Sport Medicine, University of Washington, Seattle, Washington, USA.
Goutham GanesanBeckman Laser Institute and Medical Clinic, Laser Microbeam and Medical Program, University of California Irvine, Irvine, California, USA.
Bruce J TrombergBeckman Laser Institute and Medical Clinic, Laser Microbeam and Medical Program, University of California Irvine, Irvine, California, USA.
Thomas D O'SullivanDepartment of Electrical Engineering, University of Notre Dame, Notre Dame, Indiana, USA.
Ran SchwarzkopfNYU Langone Orthopaedic Hospital, Hospital for Joint Diseases, New York, New York, USA.ORCID 0000-0003-0681-7014
University of California, Irvine · USOrthopaedic Hospital · USUniversity of Notre Dame · USUniversity of Washington · US

Funding

University of California Health Participation in the National COVID Cohort Collaborative (N3C)UL1TR001414 · NCATS · UNIVERSITY OF CALIFORNIA-IRVINE · PI COOPER, DAN M, VILAIN, ERIC J. · 2015 to 2023
$35.1M
Institute for Clinical and Translational ScienceUL1TR000153 · NCATS · UNIVERSITY OF CALIFORNIA-IRVINE · PI COOPER, DAN M · 2012 to 2015
$12.1M
Virtual Photonocs TechnologiesP41EB015890 · NIBIB · UNIVERSITY OF CALIFORNIA-IRVINE · PI BOTVINICK, ELLIOT LAWRENCE · 2012 to 2017
$7.0M
Point of care and wearable biophotonics for characterizing tissue composition and metabolismZIAHD009000 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI TROMBERG, BRUCE · 2021 to 2021
$138k
NCATS NIH HHS UL1 TR000153NCATS NIH HHS UL1 TR001414NIBIB NIH HHS P41 EB015890NIH HHS NIH P41EB015890NIH HHS NIH UL1 TR000153
6 · The paper itself

Abstract

Tourniquet use creates a reduced blood surgical field during total knee arthroplasty (TKA), however, prolonged ischemia may cause postoperative tourniquet complications. To understand the effects of tourniquet-induced ischemia, we performed a prospective observational study using quantitative broadband diffuse optical spectroscopy (DOS) to measure tissue hemodynamics and water and lipid concentrations before, during, and after tourniquet placement in subjects undergoing TKA. Data was collected for 6 months and, of the total subjects analyzed (n = 24), 22 were primary TKAs and 2 were revision TKA cases. We specifically investigated tourniquet-induced hemodynamics based upon subject-specific tissue composition and observed a significant relationship between the linear rate of deoxygenation after tourniquet inflation and water/lipid ratio (W/L, p < 0.0001) and baseline somatic tissue oxygen saturation, StO

Indexed as

Arthroplasty, Replacement, KneeHemodynamicsIschemiaHumansLipidsSpectrum AnalysisTourniquetsLipidsdiffuse opticsnoninvasivetissue oxygen saturationtotal knee arthroplastytourniquet

Identifiers

PMID35289956
PMCPMC9475493
OpenAlexW4220729606

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.