ArticleTranslational vision science & technology2022
The OCT RNFL Probability Map and Artifacts Resembling Glaucomatous Damage.
Article in Translational vision science & technology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Registration-Based Analysis of the Three-Dimensional Shape of the Retinal Nerve Fiber Layer for Detection of Glaucomatous Defects.Translational vision science & technology · 2026Article
- Predicting perimetric defects from en face maps of retinal nerve fibre layer reflectance.Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2024Article
- Anatomical Features can Affect OCT Measures Used for Clinical Decisions and Clinical Trial Endpoints.Translational vision science & technology · 2024Article
- A Model of Progression to Help Identify Macular Damage Due to Glaucoma.Investigative ophthalmology & visual science · 2023Article
- Structure-function assessment in glaucoma based on perimetric sensitivity and en face optical coherence tomography images of retinal nerve fiber bundles.Scientific reports · 2023Article
- Neurofilament Light Chain in Aqueous Humor as a Marker of Neurodegeneration in Glaucoma.Clinical ophthalmology (Auckland, N.Z.) · 2023Article
- Within-eye and between-subject variability for reflectance of the retinal nerve fibre layer.Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2022Article
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Authors and funding
10 authors.
Funding
Abstract
Purpose: The purpose of this study was to improve the diagnostic ability of the optical coherence tomography (OCT) retinal nerve fiber layer (RNFL) probability (p-) map by understanding the frequency and pattern of artifacts seen on the p-maps of healthy control (HC) eyes resembling glaucomatous damage. Methods: RNFL p-maps were generated from wide-field OCT cube scans of 2 groups of HC eyes, 200 from a commercial normative group (HC-norm) and 54 from a prospective study group, as well as from 62 patient eyes, which included 32 with early glaucoma (EG). These 32 EG eyes had 24-2 mean deviation (MD) better than -6 dB and perimetric glaucoma as defined by 24-2 and 10-2 criteria. For the HC groups, "glaucoma-like" arcuates were defined as any red region near the temporal half of the disc. Results: Seven percent of the 200 HC-norm and 11% of the 54 HC RNFL p-maps satisfied the definition of "glaucoma-like," as did all the patients' p-maps. The HC p-maps showed two general patterns of abnormal regions, "arcuate" and "temporal quadrant," and these patterns resembled those seen on some of the RNFL p-maps of the EG eyes. A "vertical midline" rule, which required the abnormal region to cross the vertical midline through the fovea, had a specificity of >99%, and a sensitivity of 75% for EG and 93% for moderate to advanced eyes. Conclusions: Glaucoma-like artifacts on RNFL p-maps are relatively common and can masquerade as arcuate and/or widespread/temporal damage. Translational Relevance: A vertical midline rule had excellent specificity. However, other OCT information is necessary to obtain high sensitivity, especially in eyes with early glaucoma.
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