Evidence map›Paper›PMID 35289742›Full record

ArticleeLife2022

Nup98-dependent transcriptional memory is established independently of transcription.

Pau Pascual-Garcia, Shawn C Little, Maya Capelson

Open access · goldAbstract read
In one paragraph

Article in eLife, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Structure, function and assembly of nuclear pore complexes.Nature reviews. Molecular cell biology · 2026
    Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Inheritance of epigenetic transcriptional memory.Current opinion in genetics & development · 2024
    Review
  10. Article
  11. Review
  12. Article
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Pau Pascual-GarciaDepartment of Cell and Developmental Biology, Penn Epigenetics Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States.
Shawn C LittleDepartment of Cell and Developmental Biology, Penn Epigenetics Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States.
Maya CapelsonDepartment of Cell and Developmental Biology, Penn Epigenetics Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States.ORCID 0000-0002-1695-316X
University of Pennsylvania · US

Funding

DROSOPHILA GENOMICS RESOURCE CENTERP40OD010949 · OD · TRUSTEES OF INDIANA UNIVERSITY · PI Andrew Zelhof · 2012 to 2026
$9.4M
Nuclear Pore Complexes As Scaffolds For Genome Architecture And Epigenetic MaintenanceR01GM124143 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI CAPELSON, MAYA · 2017 to 2025
$3.0M
NIGMS NIH HHS R01 GM124143NIH HHS P40 OD010949
6 · The paper itself

Abstract

Cellular ability to mount an enhanced transcriptional response upon repeated exposure to external cues is termed transcriptional memory, which can be maintained epigenetically through cell divisions and can depend on a nuclear pore component Nup98. The majority of mechanistic knowledge on transcriptional memory has been derived from bulk molecular assays. To gain additional perspective on the mechanism and contribution of Nup98 to memory, we used single-molecule RNA FISH (smFISH) to examine the dynamics of transcription in

Indexed as

Drosophila ProteinsEcdysoneAnimalsDrosophilaNuclear PoreNuclear Pore Complex ProteinsTranscription, GeneticTranslocation, GeneticDrosophila ProteinsEcdysoneNuclear Pore Complex ProteinschromosomesD. melanogasterepigeneticgene expressionnuclear poreNup98transcriptiontranscriptional memory

Identifiers

PMID35289742
PMCPMC8923668
OpenAlexW4220705887

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.