Evidence map›Paper›PMID 35289719›Full record

ArticlemAbs

Nebulized delivery of a broadly neutralizing SARS-CoV-2 RBD-specific nanobody prevents clinical, virological, and pathological disease in a Syrian hamster model of COVID-19.

Thomas J Esparza, Yaozong Chen, Negin P Martin, Helle Bielefeldt-Ohmann, Richard A Bowen, William D Tolbert, Marzena Pazgier, David L Brody

Abstract read
In one paragraph

Article in mAbs. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Thomas J EsparzaThe National Institute of Neurological Disorders and Stroke Intramural Research Program, Laboratory of Functional and Molecular Imaging, Bethesda, MD, USA.
Yaozong ChenDepartment of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.
Negin P MartinViral Vector Core, National Institute of Environmental Health Sciences, NIH/DHHS, NC, USA.
Helle Bielefeldt-OhmannSchool of Chemistry & Molecular Biosciences and Australian Infectious Diseases Research Centre, The University of Queensland, St Lucia, Qld, Australia.
Richard A BowenDepartment of Biomedical Sciences, Colorado State University, Fort Collins, CO, USA.
William D TolbertDepartment of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.
Marzena PazgierDepartment of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.ORCID 0000-0003-0594-5057
David L BrodyThe National Institute of Neurological Disorders and Stroke Intramural Research Program, Laboratory of Functional and Molecular Imaging, Bethesda, MD, USA.

Funding

US Department of Energy AC02-76SF00515
6 · The paper itself

Abstract

There remains an unmet need for globally deployable, low-cost therapeutics for the ongoing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic. Previously, we reported on the isolation and

Indexed as

Angiotensin-Converting Enzyme 2AnimalsAntibodies, ViralBinding SitesBroadly Neutralizing AntibodiesCOVID-19CricetinaeDisease Models, AnimalHumansLungMesocricetusNebulizers and VaporizersProtein BindingSARS-CoV-2Single-Domain AntibodiesSpike Glycoprotein, CoronavirusACE2 protein, humanAngiotensin-Converting Enzyme 2Antibodies, ViralBroadly Neutralizing AntibodiesSingle-Domain AntibodiesSpike Glycoprotein, Coronavirusspike protein, SARS-CoV-2COVID-19nebulized deliveryneutralizing nanobodySARS-CoV-2single-domain antibody

Identifiers

PMID35289719
PMCPMC8928829

What OpenQuestion holds

Textmetadata
LicenceCC0
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.