ArticleMicrobiology spectrum2022
Article in Microbiology spectrum, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 44 citations in OpenAlex.
- Longitudinal Survey of Pathogenic Leptospira Species at a Major Park in Sydney, Australia.EcoHealth · 2026Article
- The Deep Darkness microbiome: functional and taxonomic diversity in an oligotrophic temperate cave.Microbiology spectrum · 2026Article
- Environmental formermSystems · 2026Article
- A systematic review and meta-analysis ofOne health (Amsterdam, Netherlands) · 2026Review
- Leptospirosis in Southeast Asia: Investigating Seroprevalence, Transmission Patterns, and Diagnostic Challenges.Tropical medicine and infectious disease · 2026Review
- Review
- A Case of Infection with Leptospires from Three Different Serovars During a Flood in the Philippines.The American journal of tropical medicine and hygiene · 2025Article
- Bacterial communities profiles of soil in Hulu Langat recreational parks, Selangor.BMC research notes · 2025Article
- Addressing the burden of leptospirosis in Africa.Tropical diseases, travel medicine and vaccines · 2025Review
- DNA metabarcoding analysis revealed a silent prevalence of environmental pathogenicOne health (Amsterdam, Netherlands) · 2025Article
- Diagnostic Advances in Leptospirosis: A Comparative Analysis of Paraclinical Tests with a Focus on PCR.Microorganisms · 2025Review
- Into the spotlight: A spatial study of potentially underreported leptospirosis among dengue-negative patients in São Paulo city, Brazil.PLoS neglected tropical diseases · 2025Article
- Leptospirosis-Improving Healthcare Outcomes for a Neglected Tropical Disease.Open forum infectious diseases · 2025Review
- DETERMINANTS AND MAPPING OF LEPTOSPIROSIS IN KEBUMEN, INDONESIA: CASE-CONTROL STUDY.African journal of infectious diseases · 2025Article
- Detection of leptospiral antibodies and DNA in freshwater fish.Frontiers in veterinary science · 2025Article
- Sea surface temperature modulates El Niño and La Niña driven leptospirosis patterns: Evidence from causal machine learning in Colombia.PLOS global public health · 2025Article
- Flood-associated disease outbreaks and transmission in Southeast Asia.Frontiers in microbiology · 2025Review
- Leptospirosis Risk Assessment in Rodent Populations and Environmental Reservoirs in Humanitarian Aid Settings in Thailand.Microorganisms · 2024Article
- A systematic survey of environmental DNA in Palau's lakes and waterfalls reveals an increase inOne health (Amsterdam, Netherlands) · 2024Article
- Seroreactivity againstOne health (Amsterdam, Netherlands) · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 7 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Leptospirosis is a zoonotic disease caused by infection with pathogenic leptospires. Consistent with recent studies by other groups, leptospires were isolated from 89 out of 110 (80.9%) soil or water samples from varied locations in the Philippines in our surveillance study, indicating that leptospires might have a life cycle that does not involve animal hosts. However, despite previous work, it has not been confirmed whether leptospires multiply in the soil environment under various experimental conditions. Given the fact that the case number of leptospirosis is increased after flood, we hypothesized that waterlogged soil, which mimics the postflooding environment, could be a suitable condition for growing leptospires. To verify this hypothesis, pathogenic and saprophytic leptospires were seeded in the bottles containing 2.5 times as much water as soil, and bacterial counts in the bottles were measured over time. Pathogenic and saprophytic leptospires were found to increase their number in waterlogged soil but not in water or soil alone. In addition, leptospires were reisolated from soil in closed tubes for as long as 379 days. These results indicate that leptospires are in a resting state in the soil and are able to proliferate with increased water content in the environment. This notion is strongly supported by observations that the case number of leptospirosis is significantly higher in rainy seasons and increased after flood. Therefore, we reached the following conclusion: environmental soil is a potential reservoir of leptospires.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.