Evidence map›Paper›PMID 35289659›Full record

ArticleRadiology2022

Multicenter Evaluation of Multiparametric MRI Clear Cell Likelihood Scores in Solid Indeterminate Small Renal Masses.

Nicola Schieda, Matthew S Davenport, Stuart G Silverman, Barun Bagga, Daniel Barkmeier, Zane Blank, Nicole E Curci, Ankur M Doshi, Ryan T Downey, Elizabeth Edney and 8 more

Erratum issuedOpen access · hybridAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Radiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 41 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed, 3 pooled it
9.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 3 syntheses or guidelines pooled it, 69 citations in OpenAlex.

  1. SNMMI/EANM/ACNM Procedure Standard/Procedure Guideline on the Use of Molecular Imaging for Renal Mass Characterization.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2025
    Guideline
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

18 authors at 1 institution in 2 countries.

Nicola SchiedaFrom the Department of Medical Imaging, The Ottawa Hospital, University of Ottawa, Ottawa, Canada (N.S., R.M.H., C.W.); Departments of Radiology (M.S.D., D.B., N.E.C.) and Urology (M.S.D.), University of Michigan Medical Center, Ann Arbor, Mich; Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass (S.G.S., I.G., A.B.S.); Department of Radiology, NYU Langone Medical Center, New York, NY (B.B., A.M.D., N.H.); Department of Radiology, University of Nebraska Medical Center, Omaha, Neb (Z.B., R.T.D., E.E., E.G.); Department of Epidemiology, Ottawa Hospital Research Institute, Ottawa, Canada (T.R.); and Departments of Radiology and Urology, Advanced Imaging Research Center, University of Texas Southwestern Medical Center, 2201 Inwood Rd, 2nd Floor, Suite 202, Dallas, TX 75390-9085 (I.P.).ORCID 0000-0002-2653-4786
Matthew S DavenportFrom the Department of Medical Imaging, The Ottawa Hospital, University of Ottawa, Ottawa, Canada (N.S., R.M.H., C.W.); Departments of Radiology (M.S.D., D.B., N.E.C.) and Urology (M.S.D.), University of Michigan Medical Center, Ann Arbor, Mich; Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass (S.G.S., I.G., A.B.S.); Department of Radiology, NYU Langone Medical Center, New York, NY (B.B., A.M.D., N.H.); Department of Radiology, University of Nebraska Medical Center, Omaha, Neb (Z.B., R.T.D., E.E., E.G.); Department of Epidemiology, Ottawa Hospital Research Institute, Ottawa, Canada (T.R.); and Departments of Radiology and Urology, Advanced Imaging Research Center, University of Texas Southwestern Medical Center, 2201 Inwood Rd, 2nd Floor, Suite 202, Dallas, TX 75390-9085 (I.P.).ORCID 0000-0001-7943-7851
Stuart G SilvermanFrom the Department of Medical Imaging, The Ottawa Hospital, University of Ottawa, Ottawa, Canada (N.S., R.M.H., C.W.); Departments of Radiology (M.S.D., D.B., N.E.C.) and Urology (M.S.D.), University of Michigan Medical Center, Ann Arbor, Mich; Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass (S.G.S., I.G., A.B.S.); Department of Radiology, NYU Langone Medical Center, New York, NY (B.B., A.M.D., N.H.); Department of Radiology, University of Nebraska Medical Center, Omaha, Neb (Z.B., R.T.D., E.E., E.G.); Department of Epidemiology, Ottawa Hospital Research Institute, Ottawa, Canada (T.R.); and Departments of Radiology and Urology, Advanced Imaging Research Center, University of Texas Southwestern Medical Center, 2201 Inwood Rd, 2nd Floor, Suite 202, Dallas, TX 75390-9085 (I.P.).ORCID 0000-0001-9461-8028
Barun BaggaFrom the Department of Medical Imaging, The Ottawa Hospital, University of Ottawa, Ottawa, Canada (N.S., R.M.H., C.W.); Departments of Radiology (M.S.D., D.B., N.E.C.) and Urology (M.S.D.), University of Michigan Medical Center, Ann Arbor, Mich; Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass (S.G.S., I.G., A.B.S.); Department of Radiology, NYU Langone Medical Center, New York, NY (B.B., A.M.D., N.H.); Department of Radiology, University of Nebraska Medical Center, Omaha, Neb (Z.B., R.T.D., E.E., E.G.); Department of Epidemiology, Ottawa Hospital Research Institute, Ottawa, Canada (T.R.); and Departments of Radiology and Urology, Advanced Imaging Research Center, University of Texas Southwestern Medical Center, 2201 Inwood Rd, 2nd Floor, Suite 202, Dallas, TX 75390-9085 (I.P.).ORCID 0000-0002-0647-5766
Daniel BarkmeierFrom the Department of Medical Imaging, The Ottawa Hospital, University of Ottawa, Ottawa, Canada (N.S., R.M.H., C.W.); Departments of Radiology (M.S.D., D.B., N.E.C.) and Urology (M.S.D.), University of Michigan Medical Center, Ann Arbor, Mich; Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass (S.G.S., I.G., A.B.S.); Department of Radiology, NYU Langone Medical Center, New York, NY (B.B., A.M.D., N.H.); Department of Radiology, University of Nebraska Medical Center, Omaha, Neb (Z.B., R.T.D., E.E., E.G.); Department of Epidemiology, Ottawa Hospital Research Institute, Ottawa, Canada (T.R.); and Departments of Radiology and Urology, Advanced Imaging Research Center, University of Texas Southwestern Medical Center, 2201 Inwood Rd, 2nd Floor, Suite 202, Dallas, TX 75390-9085 (I.P.).ORCID 0000-0002-0061-6994
Zane BlankFrom the Department of Medical Imaging, The Ottawa Hospital, University of Ottawa, Ottawa, Canada (N.S., R.M.H., C.W.); Departments of Radiology (M.S.D., D.B., N.E.C.) and Urology (M.S.D.), University of Michigan Medical Center, Ann Arbor, Mich; Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass (S.G.S., I.G., A.B.S.); Department of Radiology, NYU Langone Medical Center, New York, NY (B.B., A.M.D., N.H.); Department of Radiology, University of Nebraska Medical Center, Omaha, Neb (Z.B., R.T.D., E.E., E.G.); Department of Epidemiology, Ottawa Hospital Research Institute, Ottawa, Canada (T.R.); and Departments of Radiology and Urology, Advanced Imaging Research Center, University of Texas Southwestern Medical Center, 2201 Inwood Rd, 2nd Floor, Suite 202, Dallas, TX 75390-9085 (I.P.).ORCID 0000-0003-1996-8946
Nicole E CurciFrom the Department of Medical Imaging, The Ottawa Hospital, University of Ottawa, Ottawa, Canada (N.S., R.M.H., C.W.); Departments of Radiology (M.S.D., D.B., N.E.C.) and Urology (M.S.D.), University of Michigan Medical Center, Ann Arbor, Mich; Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass (S.G.S., I.G., A.B.S.); Department of Radiology, NYU Langone Medical Center, New York, NY (B.B., A.M.D., N.H.); Department of Radiology, University of Nebraska Medical Center, Omaha, Neb (Z.B., R.T.D., E.E., E.G.); Department of Epidemiology, Ottawa Hospital Research Institute, Ottawa, Canada (T.R.); and Departments of Radiology and Urology, Advanced Imaging Research Center, University of Texas Southwestern Medical Center, 2201 Inwood Rd, 2nd Floor, Suite 202, Dallas, TX 75390-9085 (I.P.).ORCID 0000-0002-6968-0142
Ankur M DoshiFrom the Department of Medical Imaging, The Ottawa Hospital, University of Ottawa, Ottawa, Canada (N.S., R.M.H., C.W.); Departments of Radiology (M.S.D., D.B., N.E.C.) and Urology (M.S.D.), University of Michigan Medical Center, Ann Arbor, Mich; Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass (S.G.S., I.G., A.B.S.); Department of Radiology, NYU Langone Medical Center, New York, NY (B.B., A.M.D., N.H.); Department of Radiology, University of Nebraska Medical Center, Omaha, Neb (Z.B., R.T.D., E.E., E.G.); Department of Epidemiology, Ottawa Hospital Research Institute, Ottawa, Canada (T.R.); and Departments of Radiology and Urology, Advanced Imaging Research Center, University of Texas Southwestern Medical Center, 2201 Inwood Rd, 2nd Floor, Suite 202, Dallas, TX 75390-9085 (I.P.).ORCID 0000-0002-9415-2763
Ryan T DowneyFrom the Department of Medical Imaging, The Ottawa Hospital, University of Ottawa, Ottawa, Canada (N.S., R.M.H., C.W.); Departments of Radiology (M.S.D., D.B., N.E.C.) and Urology (M.S.D.), University of Michigan Medical Center, Ann Arbor, Mich; Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass (S.G.S., I.G., A.B.S.); Department of Radiology, NYU Langone Medical Center, New York, NY (B.B., A.M.D., N.H.); Department of Radiology, University of Nebraska Medical Center, Omaha, Neb (Z.B., R.T.D., E.E., E.G.); Department of Epidemiology, Ottawa Hospital Research Institute, Ottawa, Canada (T.R.); and Departments of Radiology and Urology, Advanced Imaging Research Center, University of Texas Southwestern Medical Center, 2201 Inwood Rd, 2nd Floor, Suite 202, Dallas, TX 75390-9085 (I.P.).ORCID 0000-0003-0117-2106
Elizabeth EdneyFrom the Department of Medical Imaging, The Ottawa Hospital, University of Ottawa, Ottawa, Canada (N.S., R.M.H., C.W.); Departments of Radiology (M.S.D., D.B., N.E.C.) and Urology (M.S.D.), University of Michigan Medical Center, Ann Arbor, Mich; Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass (S.G.S., I.G., A.B.S.); Department of Radiology, NYU Langone Medical Center, New York, NY (B.B., A.M.D., N.H.); Department of Radiology, University of Nebraska Medical Center, Omaha, Neb (Z.B., R.T.D., E.E., E.G.); Department of Epidemiology, Ottawa Hospital Research Institute, Ottawa, Canada (T.R.); and Departments of Radiology and Urology, Advanced Imaging Research Center, University of Texas Southwestern Medical Center, 2201 Inwood Rd, 2nd Floor, Suite 202, Dallas, TX 75390-9085 (I.P.).ORCID 0000-0003-0955-1071
Elon GranaderFrom the Department of Medical Imaging, The Ottawa Hospital, University of Ottawa, Ottawa, Canada (N.S., R.M.H., C.W.); Departments of Radiology (M.S.D., D.B., N.E.C.) and Urology (M.S.D.), University of Michigan Medical Center, Ann Arbor, Mich; Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass (S.G.S., I.G., A.B.S.); Department of Radiology, NYU Langone Medical Center, New York, NY (B.B., A.M.D., N.H.); Department of Radiology, University of Nebraska Medical Center, Omaha, Neb (Z.B., R.T.D., E.E., E.G.); Department of Epidemiology, Ottawa Hospital Research Institute, Ottawa, Canada (T.R.); and Departments of Radiology and Urology, Advanced Imaging Research Center, University of Texas Southwestern Medical Center, 2201 Inwood Rd, 2nd Floor, Suite 202, Dallas, TX 75390-9085 (I.P.).
Isha GujrathiFrom the Department of Medical Imaging, The Ottawa Hospital, University of Ottawa, Ottawa, Canada (N.S., R.M.H., C.W.); Departments of Radiology (M.S.D., D.B., N.E.C.) and Urology (M.S.D.), University of Michigan Medical Center, Ann Arbor, Mich; Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass (S.G.S., I.G., A.B.S.); Department of Radiology, NYU Langone Medical Center, New York, NY (B.B., A.M.D., N.H.); Department of Radiology, University of Nebraska Medical Center, Omaha, Neb (Z.B., R.T.D., E.E., E.G.); Department of Epidemiology, Ottawa Hospital Research Institute, Ottawa, Canada (T.R.); and Departments of Radiology and Urology, Advanced Imaging Research Center, University of Texas Southwestern Medical Center, 2201 Inwood Rd, 2nd Floor, Suite 202, Dallas, TX 75390-9085 (I.P.).ORCID 0000-0002-8192-367X
Rebecca M HibbertFrom the Department of Medical Imaging, The Ottawa Hospital, University of Ottawa, Ottawa, Canada (N.S., R.M.H., C.W.); Departments of Radiology (M.S.D., D.B., N.E.C.) and Urology (M.S.D.), University of Michigan Medical Center, Ann Arbor, Mich; Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass (S.G.S., I.G., A.B.S.); Department of Radiology, NYU Langone Medical Center, New York, NY (B.B., A.M.D., N.H.); Department of Radiology, University of Nebraska Medical Center, Omaha, Neb (Z.B., R.T.D., E.E., E.G.); Department of Epidemiology, Ottawa Hospital Research Institute, Ottawa, Canada (T.R.); and Departments of Radiology and Urology, Advanced Imaging Research Center, University of Texas Southwestern Medical Center, 2201 Inwood Rd, 2nd Floor, Suite 202, Dallas, TX 75390-9085 (I.P.).ORCID 0000-0002-0563-9052
Nicole HindmanFrom the Department of Medical Imaging, The Ottawa Hospital, University of Ottawa, Ottawa, Canada (N.S., R.M.H., C.W.); Departments of Radiology (M.S.D., D.B., N.E.C.) and Urology (M.S.D.), University of Michigan Medical Center, Ann Arbor, Mich; Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass (S.G.S., I.G., A.B.S.); Department of Radiology, NYU Langone Medical Center, New York, NY (B.B., A.M.D., N.H.); Department of Radiology, University of Nebraska Medical Center, Omaha, Neb (Z.B., R.T.D., E.E., E.G.); Department of Epidemiology, Ottawa Hospital Research Institute, Ottawa, Canada (T.R.); and Departments of Radiology and Urology, Advanced Imaging Research Center, University of Texas Southwestern Medical Center, 2201 Inwood Rd, 2nd Floor, Suite 202, Dallas, TX 75390-9085 (I.P.).ORCID 0000-0003-4762-8041
Cynthia WalshFrom the Department of Medical Imaging, The Ottawa Hospital, University of Ottawa, Ottawa, Canada (N.S., R.M.H., C.W.); Departments of Radiology (M.S.D., D.B., N.E.C.) and Urology (M.S.D.), University of Michigan Medical Center, Ann Arbor, Mich; Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass (S.G.S., I.G., A.B.S.); Department of Radiology, NYU Langone Medical Center, New York, NY (B.B., A.M.D., N.H.); Department of Radiology, University of Nebraska Medical Center, Omaha, Neb (Z.B., R.T.D., E.E., E.G.); Department of Epidemiology, Ottawa Hospital Research Institute, Ottawa, Canada (T.R.); and Departments of Radiology and Urology, Advanced Imaging Research Center, University of Texas Southwestern Medical Center, 2201 Inwood Rd, 2nd Floor, Suite 202, Dallas, TX 75390-9085 (I.P.).ORCID 0000-0003-2276-9235
Tim RamsayFrom the Department of Medical Imaging, The Ottawa Hospital, University of Ottawa, Ottawa, Canada (N.S., R.M.H., C.W.); Departments of Radiology (M.S.D., D.B., N.E.C.) and Urology (M.S.D.), University of Michigan Medical Center, Ann Arbor, Mich; Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass (S.G.S., I.G., A.B.S.); Department of Radiology, NYU Langone Medical Center, New York, NY (B.B., A.M.D., N.H.); Department of Radiology, University of Nebraska Medical Center, Omaha, Neb (Z.B., R.T.D., E.E., E.G.); Department of Epidemiology, Ottawa Hospital Research Institute, Ottawa, Canada (T.R.); and Departments of Radiology and Urology, Advanced Imaging Research Center, University of Texas Southwestern Medical Center, 2201 Inwood Rd, 2nd Floor, Suite 202, Dallas, TX 75390-9085 (I.P.).ORCID 0000-0001-8478-8170
Atul B ShinagareFrom the Department of Medical Imaging, The Ottawa Hospital, University of Ottawa, Ottawa, Canada (N.S., R.M.H., C.W.); Departments of Radiology (M.S.D., D.B., N.E.C.) and Urology (M.S.D.), University of Michigan Medical Center, Ann Arbor, Mich; Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass (S.G.S., I.G., A.B.S.); Department of Radiology, NYU Langone Medical Center, New York, NY (B.B., A.M.D., N.H.); Department of Radiology, University of Nebraska Medical Center, Omaha, Neb (Z.B., R.T.D., E.E., E.G.); Department of Epidemiology, Ottawa Hospital Research Institute, Ottawa, Canada (T.R.); and Departments of Radiology and Urology, Advanced Imaging Research Center, University of Texas Southwestern Medical Center, 2201 Inwood Rd, 2nd Floor, Suite 202, Dallas, TX 75390-9085 (I.P.).
Ivan PedrosaFrom the Department of Medical Imaging, The Ottawa Hospital, University of Ottawa, Ottawa, Canada (N.S., R.M.H., C.W.); Departments of Radiology (M.S.D., D.B., N.E.C.) and Urology (M.S.D.), University of Michigan Medical Center, Ann Arbor, Mich; Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass (S.G.S., I.G., A.B.S.); Department of Radiology, NYU Langone Medical Center, New York, NY (B.B., A.M.D., N.H.); Department of Radiology, University of Nebraska Medical Center, Omaha, Neb (Z.B., R.T.D., E.E., E.G.); Department of Epidemiology, Ottawa Hospital Research Institute, Ottawa, Canada (T.R.); and Departments of Radiology and Urology, Advanced Imaging Research Center, University of Texas Southwestern Medical Center, 2201 Inwood Rd, 2nd Floor, Suite 202, Dallas, TX 75390-9085 (I.P.).ORCID 0000-0002-0371-8689
Brigham and Women's Hospital · US

Funding

NON-INVASIVE PHYSIOLOGIC PREDICTORS OF AGGRESSIVENESS IN RENAL CELL CARCINOMAR01CA154475 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI PEDROSA, IVAN · 2011 to 2024
$4.3M
NCI NIH HHS R01 CA154475
6 · The paper itself

Abstract

Background Solid small renal masses (SRMs) (≤4 cm) represent benign and malignant tumors. Among SRMs, clear cell renal cell carcinoma (ccRCC) is frequently aggressive. When compared with invasive percutaneous biopsies, the objective of the proposed clear cell likelihood score (ccLS) is to classify ccRCC noninvasively by using multiparametric MRI, but it lacks external validation. Purpose To evaluate the performance of and interobserver agreement for ccLS to diagnose ccRCC among solid SRMs. Materials and Methods This retrospective multicenter cross-sectional study included patients with consecutive solid (≥25% approximate volume enhancement) SRMs undergoing multiparametric MRI between December 2012 and December 2019 at five academic medical centers with histologic confirmation of diagnosis. Masses with macroscopic fat were excluded. After a 1.5-hour training session, two abdominal radiologists per center independently rendered a ccLS for 50 masses. The diagnostic performance for ccRCC was calculated using random-effects logistic regression modeling. The distribution of ccRCC by ccLS was tabulated. Interobserver agreement for ccLS was evaluated with the Fleiss κ statistic. Results A total of 241 patients (mean age, 60 years ± 13 [SD]; 174 men) with 250 solid SRMs were evaluated. The mean size was 25 mm ± 8 (range, 10-39 mm). Of the 250 SRMs, 119 (48%) were ccRCC. The sensitivity, specificity, and positive predictive value for the diagnosis of ccRCC when ccLS was 4 or higher were 75% (95% CI: 68, 81), 78% (72, 84), and 76% (69, 81), respectively. The negative predictive value of a ccLS of 2 or lower was 88% (95% CI: 81, 93). The percentages of ccRCC according to the ccLS were 6% (range, 0%-18%), 38% (range, 0%-100%), 32% (range, 60%-83%), 72% (range, 40%-88%), and 81% (range, 73%-100%) for ccLSs of 1-5, respectively. The mean interobserver agreement was moderate (κ = 0.58; 95% CI: 0.42, 0.75). Conclusion The clear cell likelihood score applied to multiparametric MRI had moderate interobserver agreement and differentiated clear cell renal cell carcinoma from other solid renal masses, with a negative predictive value of 88%. © RSNA, 2022

Indexed as

Carcinoma, Renal CellKidney NeoplasmsMultiparametric Magnetic Resonance ImagingCross-Sectional StudiesHumansMaleMiddle AgedRetrospective Studies

Identifiers

PMID35289659
PMCPMC9794383
OpenAlexW4220916373

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