Evidence map›Paper›PMID 35289657›Full record

ArticleRadiology2022

Quantitative Chest CT Assessment of Small Airways Disease in Post-Acute SARS-CoV-2 Infection.

Josalyn L Cho, Raul Villacreses, Prashant Nagpal, Junfeng Guo, Alejandro A Pezzulo, Andrew L Thurman, Nabeel Y Hamzeh, Robert J Blount, Spyridon Fortis, Eric A Hoffman and 2 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Radiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 75 papers.

0numbers the graph read from it
0cells of the map it votes in
75citing papers in PubMed
13.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

75 citing papers in PubMed, 113 citations in OpenAlex.

  1. Trial
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  12. COVID-19 and Lung Cancer Interactions: A Literature Review.Medical sciences (Basel, Switzerland) · 2025
    Review
  13. Observational
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15 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Josalyn L Cho *From the Division of Pulmonary, Critical Care and Occupational Medicine, Department of Internal Medicine (J.L.C., R.V., A.A.P., A.L.T., N.Y.H., R.J.B., S.F., E.A.H., J.Z., A.P.C.), Department of Radiology (P.N., J.G., E.A.H.), and Roy J. Carver Department of Biomedical Engineering (J.G., E.A.H.), Carver College of Medicine, University of Iowa, 200 Hawkins Dr, W219-B GH, Iowa City, IA 52242; and Center for Access and Delivery Research and Evaluation (CADRE), Iowa City Veterans Health Administration, Iowa City, Iowa (S.F.).ORCID 0000-0002-0367-4495
Raul Villacreses *From the Division of Pulmonary, Critical Care and Occupational Medicine, Department of Internal Medicine (J.L.C., R.V., A.A.P., A.L.T., N.Y.H., R.J.B., S.F., E.A.H., J.Z., A.P.C.), Department of Radiology (P.N., J.G., E.A.H.), and Roy J. Carver Department of Biomedical Engineering (J.G., E.A.H.), Carver College of Medicine, University of Iowa, 200 Hawkins Dr, W219-B GH, Iowa City, IA 52242; and Center for Access and Delivery Research and Evaluation (CADRE), Iowa City Veterans Health Administration, Iowa City, Iowa (S.F.).ORCID 0000-0002-9928-0182
Prashant NagpalFrom the Division of Pulmonary, Critical Care and Occupational Medicine, Department of Internal Medicine (J.L.C., R.V., A.A.P., A.L.T., N.Y.H., R.J.B., S.F., E.A.H., J.Z., A.P.C.), Department of Radiology (P.N., J.G., E.A.H.), and Roy J. Carver Department of Biomedical Engineering (J.G., E.A.H.), Carver College of Medicine, University of Iowa, 200 Hawkins Dr, W219-B GH, Iowa City, IA 52242; and Center for Access and Delivery Research and Evaluation (CADRE), Iowa City Veterans Health Administration, Iowa City, Iowa (S.F.).ORCID 0000-0003-2347-034X
Junfeng GuoFrom the Division of Pulmonary, Critical Care and Occupational Medicine, Department of Internal Medicine (J.L.C., R.V., A.A.P., A.L.T., N.Y.H., R.J.B., S.F., E.A.H., J.Z., A.P.C.), Department of Radiology (P.N., J.G., E.A.H.), and Roy J. Carver Department of Biomedical Engineering (J.G., E.A.H.), Carver College of Medicine, University of Iowa, 200 Hawkins Dr, W219-B GH, Iowa City, IA 52242; and Center for Access and Delivery Research and Evaluation (CADRE), Iowa City Veterans Health Administration, Iowa City, Iowa (S.F.).ORCID 0000-0002-9397-647X
Alejandro A PezzuloFrom the Division of Pulmonary, Critical Care and Occupational Medicine, Department of Internal Medicine (J.L.C., R.V., A.A.P., A.L.T., N.Y.H., R.J.B., S.F., E.A.H., J.Z., A.P.C.), Department of Radiology (P.N., J.G., E.A.H.), and Roy J. Carver Department of Biomedical Engineering (J.G., E.A.H.), Carver College of Medicine, University of Iowa, 200 Hawkins Dr, W219-B GH, Iowa City, IA 52242; and Center for Access and Delivery Research and Evaluation (CADRE), Iowa City Veterans Health Administration, Iowa City, Iowa (S.F.).ORCID 0000-0001-7544-5109
Andrew L ThurmanFrom the Division of Pulmonary, Critical Care and Occupational Medicine, Department of Internal Medicine (J.L.C., R.V., A.A.P., A.L.T., N.Y.H., R.J.B., S.F., E.A.H., J.Z., A.P.C.), Department of Radiology (P.N., J.G., E.A.H.), and Roy J. Carver Department of Biomedical Engineering (J.G., E.A.H.), Carver College of Medicine, University of Iowa, 200 Hawkins Dr, W219-B GH, Iowa City, IA 52242; and Center for Access and Delivery Research and Evaluation (CADRE), Iowa City Veterans Health Administration, Iowa City, Iowa (S.F.).ORCID 0000-0002-7777-4165
Nabeel Y HamzehFrom the Division of Pulmonary, Critical Care and Occupational Medicine, Department of Internal Medicine (J.L.C., R.V., A.A.P., A.L.T., N.Y.H., R.J.B., S.F., E.A.H., J.Z., A.P.C.), Department of Radiology (P.N., J.G., E.A.H.), and Roy J. Carver Department of Biomedical Engineering (J.G., E.A.H.), Carver College of Medicine, University of Iowa, 200 Hawkins Dr, W219-B GH, Iowa City, IA 52242; and Center for Access and Delivery Research and Evaluation (CADRE), Iowa City Veterans Health Administration, Iowa City, Iowa (S.F.).
Robert J BlountFrom the Division of Pulmonary, Critical Care and Occupational Medicine, Department of Internal Medicine (J.L.C., R.V., A.A.P., A.L.T., N.Y.H., R.J.B., S.F., E.A.H., J.Z., A.P.C.), Department of Radiology (P.N., J.G., E.A.H.), and Roy J. Carver Department of Biomedical Engineering (J.G., E.A.H.), Carver College of Medicine, University of Iowa, 200 Hawkins Dr, W219-B GH, Iowa City, IA 52242; and Center for Access and Delivery Research and Evaluation (CADRE), Iowa City Veterans Health Administration, Iowa City, Iowa (S.F.).ORCID 0000-0001-6177-7436
Spyridon FortisFrom the Division of Pulmonary, Critical Care and Occupational Medicine, Department of Internal Medicine (J.L.C., R.V., A.A.P., A.L.T., N.Y.H., R.J.B., S.F., E.A.H., J.Z., A.P.C.), Department of Radiology (P.N., J.G., E.A.H.), and Roy J. Carver Department of Biomedical Engineering (J.G., E.A.H.), Carver College of Medicine, University of Iowa, 200 Hawkins Dr, W219-B GH, Iowa City, IA 52242; and Center for Access and Delivery Research and Evaluation (CADRE), Iowa City Veterans Health Administration, Iowa City, Iowa (S.F.).
Eric A HoffmanFrom the Division of Pulmonary, Critical Care and Occupational Medicine, Department of Internal Medicine (J.L.C., R.V., A.A.P., A.L.T., N.Y.H., R.J.B., S.F., E.A.H., J.Z., A.P.C.), Department of Radiology (P.N., J.G., E.A.H.), and Roy J. Carver Department of Biomedical Engineering (J.G., E.A.H.), Carver College of Medicine, University of Iowa, 200 Hawkins Dr, W219-B GH, Iowa City, IA 52242; and Center for Access and Delivery Research and Evaluation (CADRE), Iowa City Veterans Health Administration, Iowa City, Iowa (S.F.).ORCID 0000-0001-8456-9437
Joseph ZabnerFrom the Division of Pulmonary, Critical Care and Occupational Medicine, Department of Internal Medicine (J.L.C., R.V., A.A.P., A.L.T., N.Y.H., R.J.B., S.F., E.A.H., J.Z., A.P.C.), Department of Radiology (P.N., J.G., E.A.H.), and Roy J. Carver Department of Biomedical Engineering (J.G., E.A.H.), Carver College of Medicine, University of Iowa, 200 Hawkins Dr, W219-B GH, Iowa City, IA 52242; and Center for Access and Delivery Research and Evaluation (CADRE), Iowa City Veterans Health Administration, Iowa City, Iowa (S.F.).ORCID 0000-0002-9606-1339
Alejandro P ComellasFrom the Division of Pulmonary, Critical Care and Occupational Medicine, Department of Internal Medicine (J.L.C., R.V., A.A.P., A.L.T., N.Y.H., R.J.B., S.F., E.A.H., J.Z., A.P.C.), Department of Radiology (P.N., J.G., E.A.H.), and Roy J. Carver Department of Biomedical Engineering (J.G., E.A.H.), Carver College of Medicine, University of Iowa, 200 Hawkins Dr, W219-B GH, Iowa City, IA 52242; and Center for Access and Delivery Research and Evaluation (CADRE), Iowa City Veterans Health Administration, Iowa City, Iowa (S.F.).ORCID 0000-0003-1521-7520
University of Iowa · US

Funding

Pulmonary Toxicology Facility CoreP30ES005605 · NIEHS · UNIVERSITY OF IOWA · PI Jong Sung Kim · 1990 to 2026
$40.5M
Respiratory virus infection in early cystic fibrosis lung diseaseP01HL091842 · NHLBI · UNIVERSITY OF IOWA · PI ZABNER, JOSEPH · 2008 to 2022
$34.2M
Vector Core-Core 2P30DK054759 · NIDDK · UNIVERSITY OF IOWA · PI Amy Leanne Ryan · 1998 to 2026
$30.5M
The University of Iowa Clinical and Translational Science AwardUL1TR002537 · NCATS · UNIVERSITY OF IOWA · PI HANSEN, MARLAN R, WINOKUR, PATRICIA · 2018 to 2022
$20.0M
Multidisciplinary Lung Research Career Development ProgramT32HL007638 · NHLBI · UNIVERSITY OF IOWA · PI WELSH, MICHAEL J., ZABNER, JOSEPH · 1986 to 2020
$16.9M
Pathology CoreP01HL152960 · NHLBI · UNIVERSITY OF IOWA · PI ENGELHARDT, JOHN F · 2020 to 2024
$11.6M
Airway Alkalinization and Repurposing Tromethamine as a Therapeutic Approach in Cystic FibrosisR01HL136813 · NHLBI · UNIVERSITY OF IOWA · PI STOLTZ, DAVID A, ZABNER, JOSEPH · 2017 to 2021
$5.3M
Multi-center Structural & Functional Quantitative CT Pulmonary PhenotypingR01HL112986 · NHLBI · UNIVERSITY OF IOWA · PI HOFFMAN, ERIC ALFRED · 2012 to 2016
$4.6M
Epigenetic mechanisms of inflammatory memory propagation in human airway epitheliaR01HL163024 · NHLBI · UNIVERSITY OF IOWA · PI Alejandro Antonio Pezzulo · 2022 to 2026
$2.8M
Regulation of the host immune response to influenza by the checkpoint receptor Tim3R01HL148758 · NHLBI · UNIVERSITY OF IOWA · PI CHO, JOSALYN L · 2020 to 2024
$2.5M
Ultra-low Dose, High Speed, High Resolution, Multispectral, Multi-Source MDCT ScaS10OD018526 · OD · UNIVERSITY OF IOWA · PI HOFFMAN, ERIC ALFRED · 2015 to 2015
$2.0M
Heat-shock protein 90 modulates goblet cell metaplasia in human airway epitheliaK01HL140261 · NHLBI · UNIVERSITY OF IOWA · PI PEZZULO, ALEJANDRO ANTONIO · 2019 to 2023
$746k
NCATS NIH HHS UL1 TR002537NHLBI NIH HHS K01 HL140261NHLBI NIH HHS P01 HL091842NHLBI NIH HHS P01 HL152960NHLBI NIH HHS R01 HL112986NHLBI NIH HHS R01 HL136813NHLBI NIH HHS R01 HL148758NHLBI NIH HHS R01 HL163024NHLBI NIH HHS T32 HL007638NIDDK NIH HHS P30 DK054759NIEHS NIH HHS P30 ES005605NIH HHS S10 OD018526
6 · The paper itself

Abstract

Background The long-term effects of SARS-CoV-2 infection on pulmonary structure and function remain incompletely characterized. Purpose To test whether SARS-CoV-2 infection leads to small airways disease in patients with persistent symptoms. Materials and Methods In this single-center study at a university teaching hospital, adults with confirmed COVID-19 who remained symptomatic more than 30 days following diagnosis were prospectively enrolled from June to December 2020 and compared with healthy participants (controls) prospectively enrolled from March to August 2018. Participants with post-acute sequelae of COVID-19 (PASC) were classified as ambulatory, hospitalized, or having required the intensive care unit (ICU) based on the highest level of care received during acute infection. Symptoms, pulmonary function tests, and chest CT images were collected. Quantitative CT analysis was performed using supervised machine learning to measure regional ground-glass opacity (GGO) and using inspiratory and expiratory image-matching to measure regional air trapping. Univariable analyses and multivariable linear regression were used to compare groups. Results Overall, 100 participants with PASC (median age, 48 years; 66 women) were evaluated and compared with 106 matched healthy controls; 67% (67 of 100) of the participants with PASC were classified as ambulatory, 17% (17 of 100) were hospitalized, and 16% (16 of 100) required the ICU. In the hospitalized and ICU groups, the mean percentage of total lung classified as GGO was 13.2% and 28.7%, respectively, and was higher than that in the ambulatory group (3.7%,

Indexed as

Lung DiseasesCOVID-19FemaleHumansMaleMiddle AgedPost-Acute COVID-19 SyndromeTomography, X-Ray Computed

Identifiers

PMID35289657
PMCPMC9270680
OpenAlexW4221046032

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.