SynthesisDigestive diseases and sciences2022
Diagnostic Delay in Pediatric Inflammatory Bowel Disease: A Systematic Review.
Synthesis in Digestive diseases and sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Molecular Mechanisms Underlying the Higher Prevalence of Anemia in Crohn's Disease Compared with Ulcerative Colitis: A Systematic Review.International journal of molecular sciences · 2026Pooled it
- Between-visit care represents a substantial and underrecognized component of health care utilization in pediatric inflammatory bowel disease.Inflammatory bowel diseases · 2026Article
- Delays in Diagnosing Pediatric Inflammatory Bowel Disease in Korea: Impact on Disease Severity and the Need for Early Recognition.Journal of Korean medical science · 2026Article
- Medical Gaslighting in Gastroenterology: A Narrative Review From Pediatric and Adult Practice.Gastro hep advances · 2026Review
- The role of metabolomics in enhancing diagnosis and management of inflammatory bowel disease: a systematic review.Therapeutic advances in gastroenterology · 2026Review
- Evaluation of causal relationships between genetic liability to inflammatory bowel disease and autism spectrum disorder by Mendelian randomization analysis.Dialogues in clinical neuroscience · 2025Article
- Inflammatory bowel disease in paediatrics: Navigating the old challenges and emerging frontiers.World journal of gastroenterology · 2025Review
- Identification of key genes as diagnostic biomarkers for IBD using bioinformatics and machine learning.Journal of translational medicine · 2025Article
- Diagnostic interval of inflammatory bowel disease in Chinese children and its relationship with growth parameters: a retrospective study.Frontiers in pediatrics · 2025Article
- A nomogram for predicting the risk ofFrontiers in pediatrics · 2025Article
- Early Identification of Pediatric Inflammatory Bowel Disease Based on a Noninvasive Multivariable Predictive Model.Journal of inflammation research · 2025Article
- Multicenter registry of pediatric inflammatory bowel disease from a developing country.BMC pediatrics · 2024Article
- Identification and Validation of the Diagnostic Markers for Inflammatory Bowel Disease by Bioinformatics Analysis and Machine Learning.Biochemical genetics · 2024Article
- The deficiencies in using large databases to assess the risk of future development of inflammatory bowel disease.United European gastroenterology journal · 2024Article
- Evolving Landscape of Paediatric Inflammatory Bowel Disease: Insights from a Decade-Long Study in North-East Slovenia on Incidence, Management, Diagnostic Delays, and Early Biologic Intervention.Diagnostics (Basel, Switzerland) · 2024Article
- Identification of platelet-related subtypes and diagnostic markers in pediatric Crohn's disease based on WGCNA and machine learning.Frontiers in immunology · 2024Article
- Nutritional status of pediatric patients with inflammatory bowel diseases is related to disease duration and clinical picture at diagnosis.Scientific reports · 2023Article
- Unmet Challenges in Patients with Crohn's Disease.Journal of clinical medicine · 2023Review
- Identification of FCN1 as a novel macrophage infiltration-associated biomarker for diagnosis of pediatric inflammatory bowel diseases.Journal of translational medicine · 2023Article
- A Case of Ulcerative Colitis Induced by Paraneoplastic Syndrome?Journal of inflammation research · 2023Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionDelays in diagnosing pediatric inflammatory bowel disease (IBD) are common, but the extent of this delay remains unclear due to variations in reported time-periods between studies. The objectives of this systematic review were to examine the extent of diagnostic delay in pediatric IBD and examine any association between specific characteristics and length of diagnostic delay.
methodsWe identified studies from several medical bibliographical databases (EMBASE, Medline and CINAHL) from their inception to April 2021. Studies examining pediatric cohorts (< 18 years old) defined as having a diagnosis of Crohn's Disease (CD), ulcerative colitis (UC), or by the more general definition of IBD, and reporting a median time-period between the onset of symptoms and a final diagnosis (diagnostic delay) were included. Two reviewers selected each study, extracted data, and assessed their quality using the Newcastle-Ottawa scale. Narrative synthesis was then used to examine the extent of overall diagnostic delay and delay associated with specific sample characteristics.
resultsOf the 10,119 studies initially identified, 24 were included in the review. The overall median diagnostic delay range was 2-10.4 months for IBD, 2.0-18.0 months for UC and 4.0-24.0 months for CD. However, for approximately two thirds of UC (68.8%) and CD (66.7%) studies, delay ranged from 2.0-3.0 and 4.0-6.3 months, respectively. A longer delay was significantly associated with several sample characteristics; however, these were too infrequently examined to draw robust conclusion on their role.
conclusionChildren continue to wait several months for a final diagnosis of IBD, and those with CD experience longer delay than those with UC. The role of specific characteristics on delay needs further exploration.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.