ArticleNature cell biology2022
Leucyl-tRNA synthetase is a tumour suppressor in breast cancer and regulates codon-dependent translation dynamics.
3 registry-linked trialsOpen access · greenAbstract read
In one paragraph
Article in Nature cell biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 48 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed, 1 pooled it
5.7field-weighted citation impact, top 3% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
NCT07488312 phase1enrolling by invitationnot on this mapstarted 2025, after this paper: background citation
A Study on the Safety of Leucine-Restricted Diet in Patients With Gastric Cancer
A Study on the Safety and Efficacy of Leucine-Restricted Diet in Gastric Cancer Patients Treated With Chemotherapy and Immunotherapy
A Study on the Safety and Efficacy of Leucine-Restricted Diet in Gastric Cancer Patients Treated With Neoadjuvant Chemotherapy and Immunotherapy
Who cites it
48 citing papers in PubMed, 1 synthesis or guideline pooled it, 64 citations in OpenAlex.
- From Gene to Enzyme: Multidimensional Decoding of the GGT Molecular Family and Its Clinical Tumor Diagnosis.Cancer medicine · 2025Pooled it
- METTL1-mediated m7G modification of valine tRNAs drives metabolic adaptation in pancreatic ductal adenocarcinoma cells.The Journal of clinical investigation · 2026Article
- Nuclear localization of the glutaminyl-tRNA synthetase QARS reveals its role in DNA damage response in ovarian cancer.Nature communications · 2026Article
- Unveiling VARS1: a key driver of colorectal cancer progression and immune modulation.International journal of clinical oncology · 2026Article
- LARS regulates cellular senescence and autophagy in liver cancer cells.Cell death & disease · 2026Article
- Leucyl tRNA synthetase ameliorates cholestatic liver injury by inhibiting integrated stress response in mice.Scientific reports · 2026Article
- The regulation, function and disease relevance of cytoplasmic tRNAs.Nature reviews. Molecular cell biology · 2026Review
- Mesenchymal Tissue-Driven Gene Programs Identify EMP3 as a Key Biomarker of Aggressiveness in Undifferentiated Sarcomas.International journal of molecular sciences · 2026Article
- LARS promotes osteosarcoma proliferation through leucine-dependent PRIM2 translation and DNA replication activation.Journal of experimental & clinical cancer research : CR · 2026Article
- Aminoacyl-tRNA synthetases in tumor immunity: canonical translation, source-resolved immune circuits and therapeutic opportunities.Frontiers in immunology · 2026Review
- Methionyl-tRNA synthetase 1 participates in hepatocellular carcinoma and its regulated gene profile possesses potent prognostic ability.World journal of gastrointestinal oncology · 2025Article
- Nanopore sequencing of intact aminoacylated tRNAs.Nature communications · 2025Article
- Epigenetic control in thyroid cancer: mechanisms and clinical perspective.Cell death discovery · 2025Review
- Leucyl-tRNA synthetase promotes malignant progression in diffuse large B-cell lymphoma by regulating glycolysis via the LRPPRC/HIF-1α/HK2 axis.Human cell · 2025Article
- TRMT6-mediated tRNA mNature cancer · 2025Article
- Molecular biomarkers for the prognosis of breast cancer: role of amino acid metabolism genes.Journal of physiology and biochemistry · 2025Article
- Dissecting the Emerging Regulatory and Mechanistic Paradigms of Transcribed Conserved Non-Coding Elements in Breast Cancer.Biomolecules · 2025Article
- Multiple roles of branched-chain amino acid metabolism in tumour progression.Journal of biomedical science · 2025Review
- BBOX1 restrains TBK1-mTORC1 oncogenic signaling in clear cell renal cell carcinoma.Nature communications · 2025Article
- Quantitative proteomic analysis unveils a critical role of VARS1 in hepatocellular carcinoma aggressiveness through the modulation of MAGI1 expression.Molecular cancer · 2025Article
Corrections and comments
- Commented on by
Authors and funding
8 authors at 2 institutions in 1 country.
Maria C PassarelliLaboratory of Systems Cancer Biology, The Rockefeller University, New York, NY, USA.
Alexandra M PinzaruLaboratory of Systems Cancer Biology, The Rockefeller University, New York, NY, USA.
Hosseinali AsgharianDepartment of Biochemistry and Biophysics, University of California, San Francisco, CA, USA.ORCID http://orcid.org/0000-0001-7085-5045
Maria V LibertiLaboratory of Systems Cancer Biology, The Rockefeller University, New York, NY, USA.
Søren HeisselProteomics Resource Center, The Rockefeller University, New York, NY, USA.ORCID http://orcid.org/0000-0003-2692-5602
Henrik MolinaProteomics Resource Center, The Rockefeller University, New York, NY, USA.
Hani GoodarziDepartment of Biochemistry and Biophysics, University of California, San Francisco, CA, USA. hani.goodarzi@ucsf.edu.
Sohail F TavazoieLaboratory of Systems Cancer Biology, The Rockefeller University, New York, NY, USA. sohail.tavazoie@rockefeller.edu.ORCID http://orcid.org/0000-0002-4966-9018
Rockefeller University · USUniversity of California, San Francisco · US
Funding
Weill Cornell/Rockefeller/Sloan-Kettering MST ProgramT32GM007739 · NIGMS · WEILL MEDICAL COLL OF CORNELL UNIV · PI HSU, KATHARINE C · 1985 to 2023
$51.1MSingle-Cell & Computational Biology CoreU54CA261701 · NCI · ROCKEFELLER UNIVERSITY · PI Sohail F. Tavazoie · 2021 to 2026
$9.1MAn antisense RNA-mediated regulatory program that drives cancer metastasisR01CA240984 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GOODARZI, HANI · 2019 to 2023
$2.5MCharacterizing the Role of Leucyl Aminoacyl tRNA Synthetase (LARS) in Breast Cancer MetastasisF30CA247026 · NCI · WEILL MEDICAL COLL OF CORNELL UNIV · PI PASSARELLI, MARIA CHRISTINA · 2020 to 2023
$191kDeveloping Ribolog: A toolbox for comprehensive analysis of ribosome profiling dataF32GM133118 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ASGHARIAN, HOSSEINALI · 2019 to 2020
$97kHoward Hughes Medical InstituteNCI NIH HHS F30 CA247026NCI NIH HHS R01 CA240984NCI NIH HHS U54 CA261701NIGMS NIH HHS F32 GM133118NIGMS NIH HHS T32 GM007739
Abstract
Tumourigenesis and cancer progression require enhanced global protein translation
Indexed as
Amino Acyl-tRNA SynthetasesBreast NeoplasmsLeucine-tRNA LigaseAnimalsCodonFemaleHumansMembrane GlycoproteinsMiceRNA, TransferAmino Acyl-tRNA SynthetasesCodonEMP3 protein, humanLeucine-tRNA LigaseMembrane GlycoproteinsRNA, Transfer
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.