ArticleScientific reports2022
Long descending commissural V0v neurons ensure coordinated swimming movements along the body axis in larval zebrafish.
Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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8 citing papers in PubMed, 24 citations in OpenAlex.
- Redefining the central pattern generator for vertebrate locomotion.Nature reviews. Neuroscience · 2026Review
- Head stabilization behavior and underlying circuit mechanisms in larval zebrafish.Communications biology · 2026Article
- Coordinated spinal locomotor network dynamics emerge from cell-type-specific connectivity patterns.eLife · 2025Article
- Innovations in spinal cord cell type heterogeneity across vertebrate evolution.bioRxiv : the preprint server for biology · 2025Article
- V2b Neurons Act via Multiple Targets to Produce in Phase Inhibition during Locomotion.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Coordinated spinal locomotor network dynamics emerge from cell-type-specific connectivity patterns.bioRxiv : the preprint server for biology · 2025Article
- Cell-type-specific origins of locomotor rhythmicity at different speeds in larval zebrafish.eLife · 2024Article
- Biomechanics and neural circuits for vestibular-induced fine postural control in larval zebrafish.Nature communications · 2023Article
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Developmental maturation occurs in slow swimming behavior in larval zebrafish; older larvae acquire the ability to perform slow swimming while keeping their head stable in the yaw dimension. A class of long-distance descending commissural excitatory V0v neurons, called MCoD neurons, are known to develop in a later phase of neurogenesis, and participate in slow swimming in older larvae. We hypothesized that these MCoD neurons play a role in coordinating the activities of trunk muscles in the diagonal dimension (e.g., the rostral left and the caudal right) to produce the S-shaped swimming form that contributes to the stability of the head. Here, we show that MCoD neurons do indeed play this role. In larvae in which MCoD neurons were laser-ablated, the swimming body form often adopted a one-sided (C-shaped) bend with reduced appearance of the normal S-shaped bend. With this change in swimming form, the MCoD-ablated larvae exhibited a greater degree of head yaw displacement during slow swimming. In mice, the long-distance descending commissural V0v neurons have been implicated in diagonal interlimb coordination during walking. Together with this, our study suggests that the long-distance descending commissural V0v neurons form an evolutionarily conserved pathway in the spinal locomotor circuits that coordinates the movements of the diagonal body/limb muscles.
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