ArticleNature communications2022
The arginine methyltransferase PRMT7 promotes extravasation of monocytes resulting in tissue injury in COPD.
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In one paragraph
Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 78 papers, 2 of them syntheses that pooled it.
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78citing papers in PubMed, 2 pooled it
9.2field-weighted citation impact, top 1% of its field
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Who cites it
78 citing papers in PubMed, 2 syntheses or guidelines pooled it, 115 citations in OpenAlex.
- A systematic review of protein post-translational modifications in sepsis.Molecular biology reports · 2025Pooled it
- Recent Evidences of Epigenetic Alterations in Chronic Obstructive Pulmonary Disease (COPD): A Systematic Review.International journal of molecular sciences · 2025Pooled it
- PRMT7 restricts CD8+ T cells expansion via the NF-ΚB pathway.Nature communications · 2026Article
- Histone Post-Translational Modifications Regulating Ferroptosis: The Molecular Mechanisms and Disease Associations.Cell biochemistry and function · 2026Review
- Role of PRMT5 in regulating ferritinophagy during Mycobacterium tuberculosis infection.PLoS pathogens · 2026Article
- PRMT5 Mediates Sepsis-Associated Lung Injury by Modulating JAK1 Arginine Methylation: A Mechanism Study.The Kaohsiung journal of medical sciences · 2026Article
- Review
- Adenine nucleotide translocase 2 (ANT2) deficiency reprograms ferroptosis in alveolar progenitor cells to promote emphysema.bioRxiv : the preprint server for biology · 2026Article
- Dapagliflozin binds PRMT7 to inhibit p38 MAPK phosphorylation and macrophage foam cell formation in atherosclerosis.iScience · 2026Article
- Hallmarks of the ageing lung: 10 years later.The European respiratory journal · 2026Review
- Review
- TRPML1 suppresses pulmonary fibrosis by limiting collagen and elastin deposition.The EMBO journal · 2026Article
- Decoding organ fibrosis: mechanistic insights and emerging therapeutic strategies.Signal transduction and targeted therapy · 2026Review
- Protein Arginine Methyltransferases in γ-Globin Regulation and Sickle Cell Disease: Emerging Connections to Oxidative Stress.Antioxidants (Basel, Switzerland) · 2026Review
- New approaches to uncover COPD pathobiology and develop therapies.JCI insight · 2026Review
- Cystatin C prevents tissue injury after lung transplantation.Life science alliance · 2026Article
- Epigenetic and post-translational regulatory networks of ferroptosis in the tumor immune microenvironment.Experimental hematology & oncology · 2026Review
- Multi-omics to study chronic respiratory diseases and viral infections.European respiratory review : an official journal of the European Respiratory Society · 2026Review
- Critical Biological Functions and Clinical Implications of Epigenetic-Related Candidate Biomarkers in Chronic Obstructive Pulmonary Disease: Integrated Machine Learning Screening and Basic Experimental Validation.International journal of chronic obstructive pulmonary disease · 2026Article
- Unified platform for multiplex immunofluorescence across liver tissues and engineered models.eGastroenterology · 2026Article
18 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
50 authors at 15 institutions in 7 countries.
Gizem Günes Günsel *Institute of Lung Health and Immunity (LHI), Comprehensive Pneumology Center (CPC), Helmholtz Munich, Member of the German Center for Lung Research (DZL), 85764, Munich, Germany.
Thomas M Conlon *Institute of Lung Health and Immunity (LHI), Comprehensive Pneumology Center (CPC), Helmholtz Munich, Member of the German Center for Lung Research (DZL), 85764, Munich, Germany.ORCID http://orcid.org/0000-0002-4316-6612
Aicha Jeridi *Institute of Lung Health and Immunity (LHI), Comprehensive Pneumology Center (CPC), Helmholtz Munich, Member of the German Center for Lung Research (DZL), 85764, Munich, Germany.
Rinho KimInstitute of Functional Epigenetics, Helmholtz Munich, 85764, Munich, Germany.
Zeynep ErtüzInstitute of Lung Health and Immunity (LHI), Comprehensive Pneumology Center (CPC), Helmholtz Munich, Member of the German Center for Lung Research (DZL), 85764, Munich, Germany.
Niklas J LangInstitute of Lung Health and Immunity (LHI), Comprehensive Pneumology Center (CPC), Helmholtz Munich, Member of the German Center for Lung Research (DZL), 85764, Munich, Germany.
Meshal AnsariInstitute of Lung Health and Immunity (LHI), Comprehensive Pneumology Center (CPC), Helmholtz Munich, Member of the German Center for Lung Research (DZL), 85764, Munich, Germany.ORCID http://orcid.org/0000-0002-8819-7965
Mariia NovikovaInstitute of Metabolism and Cell Death, Helmholtz Munich, 85764, Munich, Germany.
Dongsheng JiangInstitute of Lung Health and Immunity (LHI), Comprehensive Pneumology Center (CPC), Helmholtz Munich, Member of the German Center for Lung Research (DZL), 85764, Munich, Germany.ORCID http://orcid.org/0000-0003-0961-2671
Maximilian StrunzInstitute of Lung Health and Immunity (LHI), Comprehensive Pneumology Center (CPC), Helmholtz Munich, Member of the German Center for Lung Research (DZL), 85764, Munich, Germany.
Mariia GaianovaInstitute of Lung Health and Immunity (LHI), Comprehensive Pneumology Center (CPC), Helmholtz Munich, Member of the German Center for Lung Research (DZL), 85764, Munich, Germany.
Christine HollauerInstitute of Lung Health and Immunity (LHI), Comprehensive Pneumology Center (CPC), Helmholtz Munich, Member of the German Center for Lung Research (DZL), 85764, Munich, Germany.
Christina GabrielInstitute of Lung Health and Immunity (LHI), Comprehensive Pneumology Center (CPC), Helmholtz Munich, Member of the German Center for Lung Research (DZL), 85764, Munich, Germany.
Ilias AngelidisInstitute of Lung Health and Immunity (LHI), Comprehensive Pneumology Center (CPC), Helmholtz Munich, Member of the German Center for Lung Research (DZL), 85764, Munich, Germany.
Sebastian DollInstitute of Computational Biology, Helmholtz Munich, 85764, Munich, Germany.
Jeanine C PestoniInstitute of Lung Health and Immunity (LHI), Comprehensive Pneumology Center (CPC), Helmholtz Munich, Member of the German Center for Lung Research (DZL), 85764, Munich, Germany.
Stephanie L EdelmannResearch Unit Molecular Immune Regulation, Helmholtz Munich, 81377, Munich, Germany.
Marlene Sophia KohlheppDepartment of Hepatology & Gastroenterology, Charité - Universitätsmedizin Berlin, Campus Virchow-Klinikum (CVK) and Campus Charité Mitte (CCM), 13353, Berlin, Germany.
Adrien GuillotDepartment of Hepatology & Gastroenterology, Charité - Universitätsmedizin Berlin, Campus Virchow-Klinikum (CVK) and Campus Charité Mitte (CCM), 13353, Berlin, Germany.ORCID http://orcid.org/0000-0002-6002-9986
Kevin BasslerDepartment for Genomics & Immunoregulation, LIMES-Institute, University of Bonn, 53115, Bonn, Germany.
Hannelore P Van EeckhoutteLaboratory for Translational Research in Obstructive Pulmonary Diseases, Department of Respiratory Medicine, Ghent University, University Hospital Ghent, 9000, Ghent, Belgium.
Özgecan KayalarKoç University Research Center for Translational Medicine (KUTTAM), 34010, Istanbul, Turkey.ORCID http://orcid.org/0000-0001-9107-2381
Nur KonyalilarKoç University Research Center for Translational Medicine (KUTTAM), 34010, Istanbul, Turkey.ORCID http://orcid.org/0000-0003-3693-6508
Tamara KanashovaMax-Delbrück Center for Molecular Medicine, 13125, Berlin, Germany.
Sophie RodiusProteomics of cellular signalling, Luxembourg Institute of Health, 1272, Strassen, Luxembourg.
Carolina Ballester-LópezInstitute of Lung Health and Immunity (LHI), Comprehensive Pneumology Center (CPC), Helmholtz Munich, Member of the German Center for Lung Research (DZL), 85764, Munich, Germany.
Carlos M Genes RoblesInstitute of Functional Epigenetics, Helmholtz Munich, 85764, Munich, Germany.
Natalia SmirnovaInstitute of Lung Health and Immunity (LHI), Comprehensive Pneumology Center (CPC), Helmholtz Munich, Member of the German Center for Lung Research (DZL), 85764, Munich, Germany.
Markus RehbergInstitute of Lung Health and Immunity (LHI), Comprehensive Pneumology Center (CPC), Helmholtz Munich, Member of the German Center for Lung Research (DZL), 85764, Munich, Germany.
Charu AgarwalInstitute of Lung Health and Immunity (LHI), Comprehensive Pneumology Center (CPC), Helmholtz Munich, Member of the German Center for Lung Research (DZL), 85764, Munich, Germany.
Ioanna KrikkiInstitute of Lung Health and Immunity (LHI), Comprehensive Pneumology Center (CPC), Helmholtz Munich, Member of the German Center for Lung Research (DZL), 85764, Munich, Germany.
Benoit PiavauxCzech Centre for Phenogenomics, Institute of Molecular Genetics of the Czech Academy of Sciences, 25242, Vestec, Czech Republic.
Stijn E VerledenDivision of Pneumology, KU Leuven, 3000, Leuven, Belgium.
Bart VanaudenaerdeDivision of Pneumology, KU Leuven, 3000, Leuven, Belgium.
Melanie KönigshoffDivision of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, 15261, USA.
Gunnar DittmarProteomics of cellular signalling, Luxembourg Institute of Health, 1272, Strassen, Luxembourg.ORCID http://orcid.org/0000-0003-3647-8623
Ken R BrackeLaboratory for Translational Research in Obstructive Pulmonary Diseases, Department of Respiratory Medicine, Ghent University, University Hospital Ghent, 9000, Ghent, Belgium.ORCID http://orcid.org/0000-0001-5906-4605
Joachim L SchultzeDepartment for Genomics & Immunoregulation, LIMES-Institute, University of Bonn, 53115, Bonn, Germany.
Henrik WatzPulmonary Research Institute at LungenClinic Grosshansdorf, Airway Research Center North (ARCN), German Center for Lung Research (DZL), 22927, Grosshansdorf, Germany.
Oliver EickelbergDivision of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, 15261, USA.
Tobias StoegerInstitute of Lung Health and Immunity (LHI), Comprehensive Pneumology Center (CPC), Helmholtz Munich, Member of the German Center for Lung Research (DZL), 85764, Munich, Germany.
Gerald BurgstallerInstitute of Lung Health and Immunity (LHI), Comprehensive Pneumology Center (CPC), Helmholtz Munich, Member of the German Center for Lung Research (DZL), 85764, Munich, Germany.ORCID http://orcid.org/0000-0002-7121-2567
Frank TackeDepartment of Hepatology & Gastroenterology, Charité - Universitätsmedizin Berlin, Campus Virchow-Klinikum (CVK) and Campus Charité Mitte (CCM), 13353, Berlin, Germany.ORCID http://orcid.org/0000-0001-6206-0226
Vigo HeissmeyerResearch Unit Molecular Immune Regulation, Helmholtz Munich, 81377, Munich, Germany.
Yuval RinkevichInstitute of Lung Health and Immunity (LHI), Comprehensive Pneumology Center (CPC), Helmholtz Munich, Member of the German Center for Lung Research (DZL), 85764, Munich, Germany.ORCID http://orcid.org/0000-0003-3658-0257
Hasan BayramKoç University Research Center for Translational Medicine (KUTTAM), 34010, Istanbul, Turkey.ORCID http://orcid.org/0000-0002-5236-766X
Herbert B SchillerInstitute of Lung Health and Immunity (LHI), Comprehensive Pneumology Center (CPC), Helmholtz Munich, Member of the German Center for Lung Research (DZL), 85764, Munich, Germany.ORCID http://orcid.org/0000-0001-9498-7034
Marcus ConradInstitute of Metabolism and Cell Death, Helmholtz Munich, 85764, Munich, Germany.ORCID http://orcid.org/0000-0003-1140-5612
Robert SchneiderInstitute of Functional Epigenetics, Helmholtz Munich, 85764, Munich, Germany.
Ali Önder YildirimInstitute of Lung Health and Immunity (LHI), Comprehensive Pneumology Center (CPC), Helmholtz Munich, Member of the German Center for Lung Research (DZL), 85764, Munich, Germany. oender.yildirim@helmholtz-muenchen.de.ORCID http://orcid.org/0000-0003-1969-480X
German Center for Lung Research · DEHelmholtz Zentrum München · DEKoç University · TRCharité - Universitätsmedizin Berlin · DEGhent University Hospital · BEUniversity of Bonn · DEUniversity of Pittsburgh · USCzech Academy of Sciences, Institute of Molecular Genetics · CZKU Leuven · BELudwig-Maximilians-Universität München · DELuxembourg Institute of Health · LUMax Delbrück Center · DEUniversity of Antwerp · BEUniversity of Colorado Hospital · USUniversity of Luxembourg · LU
Funding
Non-canonical WNT signaling in emphysema and lung regenerationR01HL141380 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KOENIGSHOFF, MELANIE · 2019 to 2022
$2.1MNHLBI NIH HHS R01 HL141380
Abstract
Extravasation of monocytes into tissue and to the site of injury is a fundamental immunological process, which requires rapid responses via post translational modifications (PTM) of proteins. Protein arginine methyltransferase 7 (PRMT7) is an epigenetic factor that has the capacity to mono-methylate histones on arginine residues. Here we show that in chronic obstructive pulmonary disease (COPD) patients, PRMT7 expression is elevated in the lung tissue and localized to the macrophages. In mouse models of COPD, lung fibrosis and skin injury, reduced expression of PRMT7 associates with decreased recruitment of monocytes to the site of injury and hence less severe symptoms. Mechanistically, activation of NF-κB/RelA in monocytes induces PRMT7 transcription and consequential mono-methylation of histones at the regulatory elements of RAP1A, which leads to increased transcription of this gene that is responsible for adhesion and migration of monocytes. Persistent monocyte-derived macrophage accumulation leads to ALOX5 over-expression and accumulation of its metabolite LTB4, which triggers expression of ACSL4 a ferroptosis promoting gene in lung epithelial cells. Conclusively, inhibition of arginine mono-methylation might offer targeted intervention in monocyte-driven inflammatory conditions that lead to extensive tissue damage if left untreated.
Indexed as
Protein-Arginine N-MethyltransferasesPulmonary Disease, Chronic ObstructiveAnimalsArginineHistonesHumansIntracellular Signaling Peptides and ProteinsMiceMonocytesArginineHistonesIntracellular Signaling Peptides and ProteinsPRMT2 protein, humanPRMT7 protein, humanPRMT7 protein, mouseProtein-Arginine N-Methyltransferases
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