ArticleThe Journal of allergy and clinical immunology2022
A mouse model of the LEAP study reveals a role for CTLA-4 in preventing peanut allergy induced by environmental peanut exposure.
Article in The Journal of allergy and clinical immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 27 citations in OpenAlex.
- The Role of the Indoor Exposome in Food Allergy Development.Current allergy and asthma reports · 2026Review
- Decoding Early Clues: Immune Mechanisms, Prevention, Diagnosis, and Treatment of IgE-Mediated Peanut and Tree Nut Allergy in Children.Biomedicines · 2025Review
- Oral mucosa effectively protects against peanut allergy in mice.The Journal of allergy and clinical immunology · 2024Article
- Transglutaminase-Cross-Linked Tofu Suppressed Soybean-Induced Allergic Reactions by Enhancing Intestinal Mucosa Immune Tolerance.Foods (Basel, Switzerland) · 2024Article
- Feast for thought: A comprehensive review of food allergy 2021-2023.The Journal of allergy and clinical immunology · 2024Review
- The origins and longevity of IgE responses as indicated by serological and cellular studies in mice and humans.Allergy · 2023Review
- A single priming event prevents oral tolerance to peanut.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2023Article
- Early introduction is not enough: CSACI statement on the importance of ongoing regular ingestion as a means of food allergy prevention.Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2023Article
- Targeting type 2 immunity and the future of food allergy treatment.The Journal of experimental medicine · 2023Review
- Recent insights into the mechanisms of anaphylaxis.Current opinion in immunology · 2023Review
- Article
- Peanut butter feeding induces oral tolerance in genetically diverse collaborative cross mice.Frontiers in allergy · 2023Article
- Androgen receptor signaling protects male mice from the development of immune response to peanut.American journal of clinical and experimental immunology · 2023Article
- Abatacept to induce remission of peanut allergy during oral immunotherapy (ATARI): protocol for a phase 2a randomized controlled trial.Frontiers in medicine · 2023Article
- Immune Responses at Host Barriers and Their Importance in Systemic Autoimmune Diseases.Advances in experimental medicine and biology · 2023Review
- Potential Allergenicity Response toNutrients · 2022Article
- A "LEAP" forward in understanding immune mechanisms of oral tolerance to peanut.The Journal of allergy and clinical immunology · 2022Article
- Understanding sex differences in the allergic immune response to food.AIMS allergy and immunology · 2022Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundA human study, Learning Early About Peanut Allergy (LEAP), showed that early introduction of peanut products decreases the prevalence of peanut allergy among children. However, the immunologic mechanisms mediating the protective effects of consuming peanut products are not well understood.
objectiveThe objective was to develop a mouse model that simulates the LEAP study and investigate the underlying mechanisms for the study observations.
methodsAdult naive BALB/c mice were fed a commercial peanut butter product (Skippy) or buffer control and concomitantly exposed to peanut flour through the airway or skin to mimic environmental exposure. The animals were analyzed for anaphylactic reaction and by molecular and immunologic approaches.
resultsAfter exposure to peanut flour through the airway or skin, naive mice developed peanut allergy, as demonstrated by acute and systemic anaphylaxis in response to challenge with peanut extract. Ingestion of Skippy, however, nearly abolished the increase in peanut-specific IgE and IgG and protected animals from developing anaphylaxis. Skippy-fed mice showed reduced numbers of T follicular helper (Tfh) cells and germinal center B cells in their draining lymph nodes, and single-cell RNA sequencing revealed a CD4
conclusionIngestion of a peanut product protects mice from peanut allergy induced by environmental exposure to peanuts, and the CTLA-4 pathway, which regulates Tfh cell responses, likely plays a pivotal role in this protection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.