Trial reportAmerican journal of ophthalmology2022
Risk Factors for Failure of Tube Shunt Surgery: A Pooled Data Analysis.
Trial report in American journal of ophthalmology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.
- Short-Term Outcomes of Trabeculectomy With or Without Anti-VEGF in Patients With Neovascular Glaucoma: A Systematic Review and Meta-Analysis.Translational vision science & technology · 2023Pooled it
- Treatment Outcomes in the Primary Tube Versus Trabeculectomy Study after 5 Years of Follow-up.Ophthalmology · 2022Trial
- Article
- The Association of an Electronic Frailty Index with Glaucoma Shunt Outcomes.Geriatrics (Basel, Switzerland) · 2026Article
- Association between capsulectomy shunt revision and Ahmed glaucoma valve implant exposure--Shanghai Ahmed glaucoma valve implant exposure (AGVIE) study.BMC ophthalmology · 2026Article
- Comparative outcomes of phaco-trabeculectomy versus phaco-tube implantation: a 6-year review.International ophthalmology · 2026Article
- Article
- PRESERFLO™ MicroShunt as a treatment option for highly increased intraocular pressure in primary open angle glaucoma and pseudoexfoliation glaucoma.Eye (London, England) · 2025Article
- Surgical Outcomes of Baerveldt Glaucoma Implant Versus Ahmed Glaucoma Valve in Neovascular Glaucoma: A Retrospective Multicenter Study.Advances in therapy · 2025Article
- Effect of intracameral air injection during Ahmed glaucoma valve implantation on hypertensive phase.Scientific reports · 2025Article
- Long-term Outcomes of Trabeculectomy Versus Ahmed Glaucoma Valve Implantation in Vitrectomized Eyes.Beyoglu eye journal · 2025Article
- The Severity of Prostaglandin-Associated Periorbitopathy Did Not Affect the Surgical Effectiveness of the Ahmed Glaucoma Valve.Journal of clinical medicine · 2024Article
- Ab-Externo XEN Gel stent implantation effectively treated refractory glaucoma with prior failed shunt tube.BMC ophthalmology · 2024Article
- Evaluation of machine learning approach for surgical results of Ahmed valve implantation in patients with glaucoma.BMC ophthalmology · 2024Article
- Surgical safety and efficacy of a multi-stent system, the comet stent, in Baerveldt glaucoma implant surgery: a prospective pilot study.Japanese journal of ophthalmology · 2023Article
- Defining the role of ab externo Xen gel stent in glaucomatous eyes with prior failed surgical intervention.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2023Article
- Ahmed Glaucoma Valve Implantation to Reduce Intraocular Pressure: Updated Perspectives.Clinical ophthalmology (Auckland, N.Z.) · 2023Review
- Bleb geometry and morphology after Preserflo Microshunt surgery: Risk factors for surgical failure.PloS one · 2023Article
- Outcomes of Sutureless Ahmed Glaucoma Valve Surgery: A Retrospective Study.Ophthalmology and therapy · 2022Article
- Impact of Postoperative Intraocular Pressure Spikes on Outcomes Following Goniotomy: A Comparative Study of Surgical Techniques.Journal of current glaucoma practiceArticle
Corrections and comments
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Authors and funding
10 authors at 5 institutions in 2 countries.
Funding
Abstract
purposeTo identify the risk factors associated with failure of tube shunt surgery.
designPooled analysis of 3 prospective multicenter, randomized clinical trials.
methodsA total of 621 patients with medically uncontrolled glaucoma were enrolled, including 276 from the Ahmed Baerveldt Comparison Study, 238 from the Ahmed Versus Baerveldt Study, and 107 from the tube group of the Tube Versus Trabeculectomy Study. Patients were randomized to treatment with an Ahmed glaucoma valve (model FP7) or Baerveldt glaucoma implant (model 101-350). The associations between baseline risk factors and tube shunt failure were assessed using a Cox proportional hazards regression model. The primary outcome measure was the rate of surgical failure defined as intraocular pressure (IOP) > 21 mmHg or reduced < 20% from baseline, IOP ≤ 5 mmHg, loss of light perception vision, reoperation for glaucoma, or removal of implant.
resultsThe cumulative probability of failure after tube shunt surgery was 38.3% after 5 years. In multivariable analyses, baseline factors that predicted tube shunt failure included preoperative IOP (≤ 21 mmHg compared to IOP > 21 and ≤ 25 mmHg; HR, 2.34; 95% CI, 1.52-3.61; P < .001), neovascular glaucoma (HR, 1.79; 95% CI, 1.28-2.52; P = .001), randomized treatment (for Ahmed glaucoma valve; HR, 1.36; 95% CI, 1.04-1.78; P = .025), and age (for 10 year decrease in age; HR, 1.19; 95% CI, 1.09-1.31; P < .001).
conclusionsLower preoperative IOP, neovascular glaucoma, Ahmed implantation, and younger age were predictors of tube shunt failure. This Study provides the largest prospectively collected dataset on tube shunt surgery.
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