Evidence map›Paper›PMID 35287864›Full record

ArticleCarbohydrate polymers2022

Homogalacturonan from squash: Characterization and tau-binding pattern of a sulfated derivative.

Yu Zhang, Panhang Liu, Chunyu Wang, Fuming Zhang, Robert J Linhardt, David Eliezer, Quanhong Li, Jing Zhao

Open access · greenAbstract read
In one paragraph

Article in Carbohydrate polymers, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
5.0field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 27 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Yu ZhangCollege of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, China; China National Engineering Research Center for Fruit and Vegetable Processing, Beijing 100083, China; Key Laboratory of Fruit and Vegetable Processing, Ministry of Agriculture, Beijing 100083, China.
Panhang LiuCollege of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, China; China National Engineering Research Center for Fruit and Vegetable Processing, Beijing 100083, China; Key Laboratory of Fruit and Vegetable Processing, Ministry of Agriculture, Beijing 100083, China.
Chunyu WangDepartment of Chemistry and Chemical Biology, Rensselaer Polytechnic Institute, Troy, NY, United States of America; Department of Biological Sciences, Rensselaer Polytechnic Institute, Troy, NY, United States of America; Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, NY, United States of America.
Fuming ZhangDepartment of Chemical and Biological Engineering, Rensselaer Polytechnic Institute, Troy, NY, United States of America; Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, NY, United States of America.
Robert J LinhardtDepartment of Chemistry and Chemical Biology, Rensselaer Polytechnic Institute, Troy, NY, United States of America; Department of Biological Sciences, Rensselaer Polytechnic Institute, Troy, NY, United States of America; Department of Chemical and Biological Engineering, Rensselaer Polytechnic Institute, Troy, NY, United States of America; Department of Biomedical Engineering, Rensselaer Polytechnic Institute, Troy, NY, United States of America; Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, NY, United States of America.
David EliezerDepartment of Biochemistry, Program in Structural Biology, Weill Cornell Medical College, New York, United States of America.
Quanhong LiCollege of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, China; China National Engineering Research Center for Fruit and Vegetable Processing, Beijing 100083, China; Key Laboratory of Fruit and Vegetable Processing, Ministry of Agriculture, Beijing 100083, China. Electronic address: quanhong_li@hotmail.com.
Jing ZhaoCollege of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, China; China National Engineering Research Center for Fruit and Vegetable Processing, Beijing 100083, China; Key Laboratory of Fruit and Vegetable Processing, Ministry of Agriculture, Beijing 100083, China. Electronic address: zhaojing_cau@hotmail.com.
China Agricultural University · CNRensselaer Polytechnic Institute · USCornell University · USMinistry of Agriculture and Rural Affairs · CN

Funding

Heparan Sulfate 3-O-Sulfation in Transcellular Propagation of Tauopathy in Alzheimer's DiseaseRF1AG069039 · NIA · RENSSELAER POLYTECHNIC INSTITUTE · PI LINHARDT, ROBERT J, LIU, JIAN · 2020 to 2020
$2.6M
Structure and Function of TauRF1AG066493 · NIA · WEILL MEDICAL COLL OF CORNELL UNIV · PI ELIEZER, DAVID · 2020 to 2020
$2.4M
Structure and Function of TauR01AG066493 · NIA · WEILL MEDICAL COLL OF CORNELL UNIV · PI ELIEZER, DAVID · 2024 to 2024
$589k
Heparan Sulfate 3-O-Sulfation in Transcellular Propagation of Tauopathy in Alzheimer's DiseaseR01AG069039 · NIA · RENSSELAER POLYTECHNIC INSTITUTE · PI LINHARDT, ROBERT J, LIU, JIAN · 2024 to 2024
$555k
NIA NIH HHS R01 AG066493NIA NIH HHS R01 AG069039NIA NIH HHS RF1 AG066493NIA NIH HHS RF1 AG069039
6 · The paper itself

Abstract

A pectic polysaccharide (WAP) was isolated from squash and identified as a homogalacturonan with a molecular mass of 83.2 kDa by GPC, monosaccharide composition analysis, FT-IR and NMR spectra. Sulfation modification of WAP was carried out and a sulfated derivative (SWAP) was obtained with a substitution degree of 1.81. The NMR spectrum indicated that the sulfation modification mainly occurred at the C-2 and C-3 positions of galacturonan residues. The binding pattern of SWAP to tau K18 protein was observed in 2D

Indexed as

PectinsSulfatesHeparinSpectroscopy, Fourier Transform InfraredHeparinPectinspolygalacturonic acidSulfatesBinding patternHomogalacturonanSquashSulfated polysaccharideTau K18 protein

Identifiers

PMID35287864
PMCPMC9482147
OpenAlexW4213075169

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.