ArticleeLife2022
Cerebellar modulation of memory encoding in the periaqueductal grey and fear behaviour.
Article in eLife, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 31 citations in OpenAlex.
- Cerebellar Transcranial Alternating Current Stimulation in the Theta Band Prevents Recall of the Initial Fear Association After Extinction Training.Human brain mapping · 2026Trial
- Viral Tracing Gone Viral: Expanded Possibilities Call for Increased Caution in Describing Cerebellar Network Connections.Cerebellum (London, England) · 2026Review
- Frequency-dependent cerebellar circuits independently gate social vocalizations and movement.bioRxiv : the preprint server for biology · 2026Article
- Optogenetic stimulation of Purkinje cells in the cerebellar vermis disrupts innate freezing behaviors and is highly aversive.bioRxiv : the preprint server for biology · 2026Article
- Lethal Interactions of neuronal networks in epilepsy mediated by both synaptic and volume transmission indicate approaches to prevention.Progress in neurobiology · 2025Review
- Climbing Fiber Activation Induced by Footshock in the Cerebellar Vermis Lobule IV/V of Freely Moving Mice.Physiological research · 2024Article
- Re-examining the Mysterious Role of the Cerebellum in Pain.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Review
- Control of defensive behavior by the nucleus of Darkschewitsch GABAergic neurons.National science review · 2024Article
- Brain temperature and free water increases after mild COVID-19 infection.Scientific reports · 2024Article
- [Inhibition of glutamatergic neurons in the dorsomedial periaqueductal gray alleviates excessive defensive behaviors of mice with post-traumatic stress disorder].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2024Article
- Intrinsic plasticity of Purkinje cell serves homeostatic regulation of fear memory.Molecular psychiatry · 2024Article
- Article
- Norepinephrine release in the cerebellum contributes to aversive learning.Nature communications · 2023Article
- Structural connectome alterations in anxious dogs: a DTI-based study.Scientific reports · 2023Article
- The cerebellum regulates fear extinction through thalamo-prefrontal cortex interactions in male mice.Nature communications · 2023Article
- Dynamic causal modeling reveals increased cerebellar- periaqueductal gray communication during fear extinction.Frontiers in systems neuroscience · 2023Article
- Cerebellar contributions to fear-based emotional processing: relevance to understanding the neural circuits involved in autism.Frontiers in systems neuroscience · 2023Review
- Cerebellar contribution to the regulation of defensive states.Frontiers in systems neuroscience · 2023Review
- Cerebellar control of fear learning via the cerebellar nuclei-Multiple pathways, multiple mechanisms?Frontiers in systems neuroscience · 2023Review
- The cerebellum and fear extinction: evidence from rodent and human studies.Frontiers in systems neuroscience · 2023Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 2 countries.
Funding
Abstract
The pivotal role of the periaqueductal grey (PAG) in fear learning is reinforced by the identification of neurons in male rat ventrolateral PAG (vlPAG) that encode fear memory through signalling the onset and offset of an auditory-conditioned stimulus during presentation of the unreinforced conditioned tone (CS+) during retrieval. Some units only display CS+ onset or offset responses, and the two signals differ in extinction sensitivity, suggesting that they are independent of each other. In addition, understanding cerebellar contributions to survival circuits is advanced by the discovery that (i) reversible inactivation of the medial cerebellar nucleus (MCN) during fear consolidation leads in subsequent retrieval to (a) disruption of the temporal precision of vlPAG offset, but not onset responses to CS+, and (b) an increase in duration of freezing behaviour. And (ii) chemogenetic manipulation of the MCN-vlPAG projection during fear acquisition (a) reduces the occurrence of fear-related ultrasonic vocalisations, and (b) during subsequent retrieval, slows the extinction rate of fear-related freezing. These findings show that the cerebellum is part of the survival network that regulates fear memory processes at multiple timescales and in multiple ways, raising the possibility that dysfunctional interactions in the cerebellar-survival network may underlie fear-related disorders and comorbidities.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.