ArticleBJPsych open2022
Insular activation and functional connectivity in firefighters with post-traumatic stress disorder.
Article in BJPsych open, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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Who cites it
6 citing papers in PubMed, 13 citations in OpenAlex.
- Distinct and shared neurobiological patterns in PTSD and CPTSD: evidence from resting-state fMRI.BMC psychiatry · 2026Article
- Is rumination only negative? Effects of belief in a just world on PTSD symptoms in firefighters: a moderated mediation model.Frontiers in psychology · 2026Article
- Admiration and motivation: key factors in managing PTSD among firefighters.BMC public health · 2024Article
- The role of the salience network in cognitive and affective deficits.Frontiers in human neuroscience · 2023Review
- Association of adverse childhood experiences and cortical neurite density alterations with posttraumatic stress disorder symptoms in autism spectrum disorder.Frontiers in psychiatry · 2023Article
- Metabolic alterations in the right anterior insula among patients with cirrhosis without overt hepatic encephalopathy: a magnetic resonance spectroscopy study.Frontiers in neurology · 2023Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
backgroundFirefighters are frequently exposed to stressful situations and are at high risk of developing post-traumatic stress disorder (PTSD). Hyperresponsiveness to threatening and emotional stimuli and diminishment of executive control have been suggested as manifestations of PTSD.
aimsTo examine brain activation in firefighters with PTSD by conducting an executive control-related behavioural task with trauma-related interferences.
methodTwelve firefighters with PTSD and 14 healthy firefighters underwent functional magnetic resonance imaging (fMRI) while performing a Stroop match-to-sample task using trauma-related photographic stimuli. Seed-based functional connectivity analysis was conducted using regions identified in fMRI contrast analysis.
resultsCompared with the controls, the participants with PTSD had longer reaction times when the trauma-related interferences were presented. They showed significantly stronger brain activation to interfering trauma-related stimuli in the left insula, and had weaker insular functional connectivity in the supplementary motor area and the anterior cingulate cortex than the controls. They also showed a significant correlation between left insula-supplementary motor area connectivity strength and the hyperarousal subscale of the Clinician-Administered PTSD Scale.
conclusionsOur findings indicate that trauma-related stimuli elicit excessive brain activation in the left insula among firefighters with PTSD. Firefighters with PTSD also appear to have weak left insular functional connectivity with executive control-related brain regions. This aberrant insular activation and functional connectivity could be related to the development and maintenance of PTSD symptoms in firefighters.
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