Evidence map›Paper›PMID 35287715›Full record

ArticleClinical epigenetics2022

Increases in ambient air pollutants during pregnancy are linked to increases in methylation of IL4, IL10, and IFNγ.

Juan Aguilera, Xiaorui Han, Shu Cao, John Balmes, Fred Lurmann, Tim Tyner, Liza Lutzker, Elizabeth Noth, S Katharine Hammond, Vanitha Sampath and 7 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical epigenetics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
3.2field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 30 citations in OpenAlex.

  1. Review
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  12. Particulate matter-induced epigenetic modifications and lung complications.European respiratory review : an official journal of the European Respiratory Society · 2024
    Review
  13. Review
  14. Air pollution and pregnancy.Seminars in perinatology · 2023
    Article
  15. Granzymes, IL-16, and poly(ADP-ribose) polymerase 1 increase during wildfire smoke exposure.The journal of allergy and clinical immunology. Global · 2023
    Article
  16. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 5 institutions in 1 country.

Juan AguileraSean N. Parker Center for Allergy and Asthma Research, Stanford University, 240 Pasteur, Stanford, CA, 94305, USA.ORCID 0000-0002-6451-0662
Xiaorui HanSean N. Parker Center for Allergy and Asthma Research, Stanford University, 240 Pasteur, Stanford, CA, 94305, USA.
Shu CaoSean N. Parker Center for Allergy and Asthma Research, Stanford University, 240 Pasteur, Stanford, CA, 94305, USA.
John BalmesDivision of Environmental Health Sciences, School of Public Health, University of California, Berkeley, CA, USA.
Fred LurmannSonoma Technology, Petaluma, CA, USA.
Tim TynerUniversity of California, San Francisco-Fresno, Fresno, CA, USA.
Liza LutzkerDivision of Environmental Health Sciences, School of Public Health, University of California, Berkeley, CA, USA.
Elizabeth NothDivision of Environmental Health Sciences, School of Public Health, University of California, Berkeley, CA, USA.
S Katharine HammondDivision of Environmental Health Sciences, School of Public Health, University of California, Berkeley, CA, USA.
Vanitha SampathSean N. Parker Center for Allergy and Asthma Research, Stanford University, 240 Pasteur, Stanford, CA, 94305, USA.
Trevor BurtDepartment of Pediatrics, Division of Neonatology and the Translating Duke Health Children's Health and Discovery Initiative, Duke University School of Medicine, 701 W Main St., Chesterfield Building, Suite 510, Durham, NC, 27701, USA.
P J UtzDepartment of Medicine, Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford University, 291 Campus Drive, Stanford, CA, 94305, USA.
Purvesh KhatriCenter for Biomedical Informatics, Department of Medicine, Stanford University School of Medicine, Stanford University, 291 Campus Drive, Stanford, CA, 94305, USA.
Nima AghaeepourDepartments of Biomedical Data Sciences, Stanford University, 291 Campus Drive, Stanford, CA, 94305, USA.
Holden MaeckerInstitute for Immunity, Transplantation and Infection, Stanford University, 291 Campus Drive, Stanford, CA, 94305, USA.
Mary PrunickiSean N. Parker Center for Allergy and Asthma Research, Stanford University, 240 Pasteur, Stanford, CA, 94305, USA.
Kari NadeauSean N. Parker Center for Allergy and Asthma Research, Stanford University, 240 Pasteur, Stanford, CA, 94305, USA. knadeau@stanford.edu.ORCID 0000-0002-2146-2955
Stanford University · USUniversity of California, Berkeley · USUniversity of California, San Francisco · USDuke University · USSonoma Technology (United States) · US

Funding

UC Berkeley/Stanford Children's Enviromental Health CenterP01ES022849 · NIEHS · UNIVERSITY OF CALIFORNIA BERKELEY · PI BALMES, JOHN R, HAMMOND, S KATHARINE · 2013 to 2018
$4.2M
Fresno Asthmatic Children's Environment Study (FACES)R01HL081521 · NHLBI · UNIVERSITY OF CALIFORNIA BERKELEY · PI TAGER, IRA B · 2006 to 2010
$3.8M
Immune Tolerance Dysfunction in Pregnancy due to Ambient Air Pollution ExposureR01ES032253 · NIEHS · STANFORD UNIVERSITY · PI NADEAU, KARI C. · 2020 to 2024
$2.2M
CHAPS Cohort MaintenanceR24ES030888 · NIEHS · UNIVERSITY OF CALIFORNIA BERKELEY · PI BALMES, JOHN R, HOLLAND, NINA T · 2020 to 2025
$1.9M
Project 3: Ambient Pollutants/Bioaerosol Effects on Treg FunctionP20ES018173 · NIEHS · UNIVERSITY OF CALIFORNIA BERKELEY · PI HAMMOND, S KATHARINE · 2010 to 2012
$895k
NHLBI NIH HHS R01 HL081521NIEHS NIH HHS P01 ES022849NIEHS NIH HHS P20 ES018173NIEHS NIH HHS R01 ES032253NIEHS NIH HHS R24 ES030888
6 · The paper itself

Abstract

backgroundAmbient air pollutant (AAP) exposure is associated with adverse pregnancy outcomes, such as preeclampsia, preterm labor, and low birth weight. Previous studies have shown methylation of immune genes associate with exposure to air pollutants in pregnant women, but the cell-mediated response in the context of typical pregnancy cell alterations has not been investigated. Pregnancy causes attenuation in cell-mediated immunity with alterations in the Th1/Th2/Th17/Treg environment, contributing to maternal susceptibility. We recruited women (n = 186) who were 20 weeks pregnant from Fresno, CA, an area with chronically elevated AAP levels. Associations of average pollution concentration estimates for 1 week, 1 month, 3 months, and 6 months prior to blood draw were associated with Th cell subset (Th1, Th2, Th17, and Treg) percentages and methylation of CpG sites (IL4, IL10, IFNγ, and FoxP3). Linear regression models were adjusted for weight, age, season, race, and asthma, using a Q value as the false-discovery-rate-adjusted p-value across all genes.

resultsShort-term and mid-term AAP exposures to fine particulate matter (PM

conclusionExposure to several AAPs was negatively associated with T-helper subsets involved in pro-inflammatory and anti-inflammatory responses during pregnancy. Methylation of IL4, IL10, and IFNγ genes with pollution exposure confirms previous research. These results offer insights into the detrimental effects of air pollution during pregnancy, the demand for more epigenetic studies, and mitigation strategies to decrease pollution exposure during pregnancy.

Indexed as

Air PollutantsEnvironmental PollutantsDNA MethylationEnvironmental ExposureFemaleHumansInfant, NewbornInterferon-gammaInterleukin-10Interleukin-4Nitrogen DioxideParticulate MatterPregnancyPregnancy OutcomeAir PollutantsEnvironmental PollutantsIL10 protein, humanInterferon-gammaInterleukin-10Interleukin-4Nitrogen DioxideParticulate MatterAir pollutionDNA methylationIFNγIL10IL4ImmunologyPM2.5PregnancyTh1Th2

Identifiers

PMID35287715
PMCPMC8919561
OpenAlexW4220699882

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.