Evidence map›Paper›PMID 35287545›Full record

ArticleAutophagy2022

Follicular lymphoma-associated mutations in the V-ATPase chaperone VMA21 activate autophagy creating a targetable dependency.

Fangyang Wang, Ying Yang, Gabriel Boudagh, Eeva-Liisa Eskelinen, Daniel J Klionsky, Sami N Malek

Open access · bronzeAbstract read
In one paragraph

Article in Autophagy, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 17 citations in OpenAlex.

  1. Lysosome as a Chemical Reactor.International journal of molecular sciences · 2025
    Review
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Structural basis of V-ATPase VProceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  10. Article
  11. Advances in the multi-omics landscape of follicular lymphoma.International journal of biological sciences · 2023
    Review
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Fangyang WangInternal Medicine, Division of Hematology and Oncology, University of Michigan, Ann Arbor, MI, USA.
Ying YangDepartments of Molecular, Cellular and Developmental Biology, and Life Sciences Institute, University of Michigan, Ann Arbor, MI, USA.ORCID 0000-0003-1602-1212
Gabriel BoudaghInternal Medicine, Division of Hematology and Oncology, University of Michigan, Ann Arbor, MI, USA.
Eeva-Liisa EskelinenInstitute of Biomedicine, University of Turku, Turku, Finland.
Daniel J KlionskyDepartments of Molecular, Cellular and Developmental Biology, and Life Sciences Institute, University of Michigan, Ann Arbor, MI, USA.ORCID 0000-0002-7828-8118
Sami N MalekInternal Medicine, Division of Hematology and Oncology, University of Michigan, Ann Arbor, MI, USA.
University of Michigan · USUniversity of Turku · FI

Funding

XenograftP30CA046592 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Alexey I Nesvizhskii · 1988 to 2026
$178.2M
The mechanism and regulation of autophagyR35GM131919 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI DANIEL J. KLIONSKY · 2019 to 2026
$6.4M
The genomic pathogenesis of Follicular LymphomaR01CA190384 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MALEK, SAMI NIMER, WENDEL, HANS-GUIDO · 2015 to 2019
$2.7M
NCI NIH HHS P30 CA046592NCI NIH HHS R01 CA190384NIGMS NIH HHS R35 GM131919
6 · The paper itself

Abstract

The discovery of recurrent mutations in subunits and regulators of the vacuolar-type H

Indexed as

Lymphoma, FollicularVacuolar Proton-Translocating ATPasesAutophagyHumansLysosomesMolecular ChaperonesMutationMolecular ChaperonesVacuolar Proton-Translocating ATPasesVMA21 protein, humanautophagyfollicular lymphomalysosomal dysfunctionsurvivalVMA21 mutations

Identifiers

PMID35287545
PMCPMC9450968
OpenAlexW4220883255

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.