ArticleScience China. Life sciences2022
Integration of rhythmic metabolome and transcriptome provides insights into the transmission of rhythmic fluctuations and temporal diversity of metabolism in rice.
Article in Science China. Life sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 19 citations in OpenAlex.
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- CDP-DAG synthases regulate plant growth and broad-spectrum disease resistance.Plant signaling & behavior · 2025Article
- Integrative phenomics, metabolomics and genomics analysis provides new insights for deciphering the genetic basis of metabolism in polished rice.Genome biology · 2025Article
- Photoperiod-Dependent Nutrient Accumulation in Rice Cultivated in Plant Factories: A Comparative Metabolomic Analysis.Foods (Basel, Switzerland) · 2024Article
- Formation mechanism and regulation analysis of trumpet leaf inFrontiers in plant science · 2024Article
- High-quality Cymbidium mannii genome and multifaceted regulation of crassulacean acid metabolism in epiphytes.Plant communications · 2023Article
- Population analysis reveals the roles of DNA methylation in tomato domestication and metabolic diversity.Science China. Life sciences · 2023Article
- Metabolomics revealed metabolite biomarkers of antioxidant properties and flavonoid metabolite accumulation in purple rice after grain filling.Food chemistry: X · 2023Article
- Integrated Metabolome and Transcriptome during Fruit Development Reveal Metabolic Differences and Molecular Basis betweenMetabolites · 2023Article
- Integrated transcriptomic analysis identifies coordinated responses to nitrogen and phosphate deficiency in rice.Frontiers in plant science · 2023Article
- Multi-omics analyses reveal the crosstalk between the circadian clock and the response to herbicide application inFrontiers in plant science · 2023Article
- Transcriptome and Metabolome Analysis Provides Insights into the Heterosis of Yield and Quality Traits in Two Hybrid Rice Varieties (International journal of molecular sciences · 2022Article
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Authors and funding
18 authors at 3 institutions in 3 countries.
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Abstract
Various aspects of the organisms adapt to cyclically changing environmental conditions via transcriptional regulation. However, the role of rhythmicity in altering the global aspects of metabolism is poorly characterized. Here, we subjected four rice (Oryza sativa) varieties to a range of metabolic profiles and RNA-seq to investigate the temporal relationships of rhythm between transcription and metabolism. More than 40% of the rhythmic genes and a quarter of metabolites conservatively oscillated across four rice accessions. Compared with the metabolome, the transcriptome was more strongly regulated by rhythm; however, the rhythm of metabolites had an obvious opposite trend between day and night. Through association analysis, the time delay of rhythmic transmission from the transcript to the metabolite level was ∼4 h under long-day conditions, although the transmission was nearly synchronous for carbohydrate and nucleotide metabolism. The rhythmic accumulation of metabolites maintained highly coordinated temporal relationships in the metabolic network, whereas the correlation of some rhythmic metabolites, such as branched-chain amino acids (BCAAs), was significantly different intervariety. We further demonstrated that the cumulative diversity of BCAAs was due to the differential expression of branched-chain aminotransferase 2 at dawn. Our research reveals the flexible pattern of rice metabolic rhythm existing with conservation and diversity.
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