ArticleAnalytical sciences : the international journal of the Japan Society for Analytical Chemistry2022
Development of an odorant sensor with a cell-free synthesized olfactory receptor and a graphene field-effect transistor.
Article in Analytical sciences : the international journal of the Japan Society for Analytical Chemistry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 10 citations in OpenAlex.
- Eukaryotic cell-free protein synthesis: Chassis diversification, system engineering, and emerging applications.Synthetic and systems biotechnology · 2026Review
- Designer artificial environments for membrane protein synthesis.Nature communications · 2025Article
- Half a Century of Progress: The Evolution of Wheat Germ-Based In Vitro Translation into a Versatile Protein Production Method.International journal of molecular sciences · 2025Review
- Analytical evaluation of food quality.Analytical sciences : the international journal of the Japan Society for Analytical Chemistry · 2024Article
- Recent development of electrochemical devices in analytical chemistry.Analytical sciences : the international journal of the Japan Society for Analytical Chemistry · 2023Article
- Identification of Cadmium Compounds in a Solution Using Graphene-Based Sensor Array.Sensors (Basel, Switzerland) · 2023Article
- Transcuticular calcium imaging as a tool for the functional study of insect odorant receptors.Frontiers in molecular neuroscience · 2023Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Animals sense odorants using olfactory receptors. Many trials have been conducted to develop artificial odorant sensors using olfactory receptors. However, the development has been hindered by the difficulty in obtaining olfactory receptors. In this study, we expressed an olfactory receptor, cOR52, using a wheat germ cell-free synthesis system. The functionality of the expressed cOR52 was confirmed by ligand concentration-dependent interactions with the mini-G protein. The expressed cOR52 was immobilized on a graphene field-effect transistor. The cOR52-modified graphene field-effect transistor exhibited a ligand-specific response between 100 nM and 100 µM. This approach seems to be applicable for other olfactory receptors. Therefore, it will be possible to develop an odorant sensor equipped with various olfactory receptors by this method.
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