Evidence map›Paper›PMID 35286569›Full record

Trial reportSleep & breathing = Schlaf & Atmung2023

Effect of Zolpidem on nocturnal arousals and susceptibility to central sleep apnea.

Bachar Ahmad, Abdulghani Sankari, Mehdi Eshraghi, Ahmad Aldwaikat, Hossein Yarandi, Salam Zeineddine, Anan Salloum, M Safwan Badr

Registry-linked trialOpen access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Sleep & breathing = Schlaf & Atmung, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04720547 (Sleep and Breathing in Health and Disease), which is not on this map. Cited by 7 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 2 pooled it
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04720547 phase4completednot on this map

Sleep and Breathing in Health and Disease (Part 2A - Chemical Stimuli, Sleep and Breathing in the General Population)

TypeinterventionalSponsorWayne State UniversityRan2018 to 2020Enrolled14ConditionsSleep-disordered BreathingArmsZolpidem, No Treatment
3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 2 syntheses or guidelines pooled it, 10 citations in OpenAlex.

  1. Hypnotics on Obstructive Sleep Apnea Severity and Endotypes: A Systematic Review and Meta-Analysis.American journal of respiratory and critical care medicine · 2024
    Pooled it
  2. Pharmacological treatment for central sleep apnoea in adults.The Cochrane database of systematic reviews · 2023
    Pooled it
  3. Review
  4. Progress in understanding the mechanism of sleep apnea in patients with PTSD.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2026
    Article
  5. Research priorities to improve classification of sleep-wake disorders.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2026
    Review
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Bachar AhmadDepartment of Internal Medicine, Wayne State University School of Medicine, 4646 John R, Detroit, MI, 48201, USA.
Abdulghani SankariDepartment of Internal Medicine, Wayne State University School of Medicine, 4646 John R, Detroit, MI, 48201, USA. asankari@wayne.edu.ORCID 0000-0002-2400-3375
Mehdi EshraghiDepartment of Internal Medicine, Wayne State University School of Medicine, 4646 John R, Detroit, MI, 48201, USA.
Ahmad AldwaikatDepartment of Internal Medicine, Wayne State University School of Medicine, 4646 John R, Detroit, MI, 48201, USA.
Hossein YarandiDepartment of Biostatistics, Wayne State University School of Medicine, Detroit, MI, USA.
Salam ZeineddineDepartment of Internal Medicine, Wayne State University School of Medicine, 4646 John R, Detroit, MI, 48201, USA.
Anan SalloumDepartment of Internal Medicine, Wayne State University School of Medicine, 4646 John R, Detroit, MI, 48201, USA.
M Safwan BadrDepartment of Internal Medicine, Wayne State University School of Medicine, 4646 John R, Detroit, MI, 48201, USA.
Wayne State University · US

Funding

Sleep-Disordered Breathing in patients with C-SCI: Mechanisms and TherapyR01HL130552 · NHLBI · WAYNE STATE UNIVERSITY · PI BADR, M.SAFWAN · 2016 to 2020
$1.5M
Central Sleep Apnea: Physiologic Mechanisms to Inform TreatmentI01CX001944 · VA · JOHN D DINGELL VA MEDICAL CENTER · PI M.Safwan Badr · 2020 to 2026
–
CSRD VA I01 CX001944NHLBI NIH HHS R01 HL130552NIH HHS R01HL130552U.S. Department of Veterans Affairs CX001944-01
6 · The paper itself

Abstract

purposeArousals may contribute to the pathogenesis of sleep-disordered breathing (SDB) and central sleep apnea (CSA). We aimed to determine the effect of the nonbenzodiazepine hypnotic zolpidem on the frequency of respiratory-related arousals and central apnea in patients with moderate-to-severe SDB. We hypothesized that zolpidem decreases the severity of SDB by decreasing the frequency of respiratory-related arousals.

methodsPatients with apnea-hypopnea index ≥ 15 events/hour and central apnea-hypopnea index ≥ 5 events/hour underwent a sleep study on zolpidem 5 mg and a sleep study with no medication in a randomized order. The respiratory arousal index was compared between the two studies using a randomized crossover design. Sleep, respiratory, and physiologic parameters, including the CO

resultsEleven participants completed the study. Compared to no treatment, zolpidem reduced the respiratory arousal index (39.7 ± 7.7 vs. 23.3 ± 4.4 events/h, P = 0.031). Zolpidem also lowered the total apnea-hypopnea index (55.6 ± 8.5 vs. 41.3 ± 7.5 events/hour, P = 0.033) but did not affect other clinical and physiologic parameters. Compared to control, zolpidem did not widen CO

conclusionNocturnal arousals and overall SDB severity were reduced with a single dose of zolpidem in patients with moderate-to-severe sleep-disordered breathing with increased susceptibility for central apnea. Zolpidem did not widen the CO

trial registrationClinicaltrials.gov. Sleep and Breathing in the General Population - Chemical Stimuli (NCT04720547).

Indexed as

Sleep Apnea, CentralSleep Apnea SyndromesArousalCarbon DioxideCross-Over StudiesHumansZolpidemCarbon DioxideZolpidemAmbienCentral sleep apneaPolysomnographySleep-disordered breathingZolpidem

Identifiers

PMID35286569
PMCPMC9470768
OpenAlexW4220996214

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.