ArticleEJNMMI physics2022
The magnitude of the partial volume effect in SPECT imaging of the kidneys: a phantom study.
Article in EJNMMI physics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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22 citing papers in PubMed, 31 citations in OpenAlex.
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- Estimation and Correction of the Partial Volume Effect Using Personalized Phantoms of Lymph Node Metastases in Lutetium 177 SPECT/CT Dosimetry.Molecular imaging and biology · 2026Article
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- Critical review of partial volume correction methods in PET and SPECT imaging: benefits, pitfalls, challenges, and future outlook.European journal of nuclear medicine and molecular imaging · 2026Review
- Towards practical radiopharmaceutical treatment planning: a review of dosimetry simplification techniques.Theranostics · 2026Review
- MIRD Pamphlet No. 33: MIRDpvc-A Software Tool for Recovery Coefficient-Based Partial-Volume Correction.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2025Article
- Investigation of the Partial Volume Effect in Pre-Dosimetry of Liver Tumors forMolecular imaging and radionuclide therapy · 2025Article
- 3D-Printed Organ-Realistic Phantoms to Verify Quantitative SPECT/CT Accuracy for 177Lu-PSMA-617 Treatment Planning.Pharmaceuticals (Basel, Switzerland) · 2025Article
- MIRD Pamphlet No. 32: A MIRD Recovery Coefficient Model for Resolution Characterization and Shape-Specific Partial-Volume Correction.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2025Article
- Calculation of recovery coefficients for partial volume effect correction in PET/CT imaging using a customized anthropomorphic body phantom.Biomedical engineering online · 2025Article
- Position dependence of recovery coefficients inEJNMMI physics · 2024Article
- Anatomy-based correction of kidney PVE on [Formula: see text] SPECT images.EJNMMI physics · 2024Article
- The Challenge of Single-Photon Emission Computed Tomography Image Segmentation in the Internal Dosimetry ofJournal of imaging · 2024Review
- Activity quantification and dosimetry in radiopharmaceutical therapy with reference toFrontiers in nuclear medicine · 2024Review
- A single-institution experience withFrontiers in oncology · 2024Article
- A Review on the Use of Imaging Biomarkers in Oncology Clinical Trials: Quality Assurance Strategies for Technical Validation.Tomography (Ann Arbor, Mich.) · 2023Review
- Tumor dosimetry usingEJNMMI physics · 2023Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSingle-photon emission computed tomography (SPECT) can cause an over- or underestimation of tissue activity concentration due to limitations in spatial resolution compared to the structures under study. This is commonly referred to as partial volume effect (PVE). Ideally, the PVE should be controlled for and corrected. One such correction method involves determining recovery coefficients (RC) from phantom measurements. In the literature, several studies applying simplified geometries are available. In this study, we aimed to determine kidney PVE for realistic kidney geometries. Furthermore, we proposed a new surrogate metric for predicting the extent of PVE in kidneys. MATERIAL AND
methodsBased on patients' CT data, we manufactured fillable phantoms using a 3D-printer. Nine cortex-only and ten whole-parenchyma phantoms were obtained, and one ellipsoidal phantom for comparison. To measure PVE, we placed the phantoms in a torso phantom and filled them with a specified activity concentration. The phantoms' RCs were determined from fully quantitative SPECT/CT acquisitions at three different target-to-background ratios (TBRs). Additionally, the surface area-to-volume (SA:V) ratio was determined for all phantoms and correlated with RCs.
resultsFor SPECT reconstructions with 36 iterations, average RC ± one standard deviation at a 10-to-1 TBR was 76.3 ± 1.5% and 48.4 ± 8.3% for whole-parenchyma and cortex-only phantoms, respectively. The RC for the ellipsoidal phantom was 85.4%. The RC for whole-parenchyma was significantly higher than for cortex-only phantoms (p < 0.01). The RC variance was significantly higher for cortex-only phantoms (p < 0.01). A highly significant correlation of the SA:V ratio and RC was found for all phantoms. (R
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