ArticleBrain structure & function2022
Structural connectivity in ventral language pathways characterizes non-verbal autism.
Article in Brain structure & function, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- The superior temporal asymmetrical pit remains asymmetric in autism spectrum disorder.bioRxiv : the preprint server for biology · 2026Article
- Multimodal predictors of spoken vocabulary development in autism: the role of early childhood brain and behavior.Translational psychiatry · 2026Article
- Impaired semantic word learning in primary progressive aphasia.Brain structure & function · 2026Article
- Brain function in language and associated networks in non- or minimally verbal children.Brain communications · 2026Article
- Mapping along-tract commissural and association white matter microstructural differences in autistic children and young adults.Cerebral cortex (New York, N.Y. : 1991) · 2025Article
- White matter correlates of language ability in chinese boys with autism spectrum disorder: a diffusional kurtosis imaging study.European journal of pediatrics · 2025Article
- White matter microstructure of language pathways in non-verbal autism: insights from diffusion tensor imaging and myelin water imaging.Frontiers in human neuroscience · 2025Article
- Bridging the Divide: Brain and Behavior in Developmental Language Disorder.Brain sciences · 2023Review
- The right uncinate fasciculus supports verbal short-term memory in aphasia.Brain structure & function · 2023Article
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6 authors.
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Abstract
Language capacities in autism spectrum disorders (ASD) range from normal scores on standardized language tests to absence of functional language in a substantial minority of 30% of individuals with ASD. Due to practical difficulties of scanning at this severe end of the spectrum, insights from MRI are scarce. Here we used manual deterministic tractography to investigate, for the first time, the integrity of the core white matter tracts defining the language connectivity network in non-verbal ASD (nvASD): the three segments of the arcuate (AF), the inferior fronto-occipital (IFOF), the inferior longitudinal (ILF) and the uncinate (UF) fasciculi, and the frontal aslant tract (FAT). A multiple case series of nine individuals with nvASD were compared to matched individuals with verbal ASD (vASD) and typical development (TD). Bonferroni-corrected repeated measure ANOVAs were performed separately for each tract-Hemisphere (2:Left/Right) × Group (3:TD/vASD/nvASD). Main results revealed (i) a main effect of group consisting in a reduction in fractional anisotropy (FA) in the IFOF in nvASD relative to TD; (ii) a main effect of group revealing lower values of radial diffusivity (RD) in the long segment of the AF in nvASD compared to vASD group; and (iii) a reduced volume in the left hemisphere of the UF when compared to the right, in the vASD group only. These results do not replicate volumetric differences of the dorsal language route previously observed in nvASD, and instead point to a disruption of the ventral language pathway, in line with semantic deficits observed behaviourally in this group.
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