Evidence map›Paper›PMID 35286175›Full record

ArticleJournal of child neurology2022

Evaluation of Febrile Seizure Diagnoses Associated With COVID-19.

Katsiah Cadet, Jessica Boegner, Gary D Ceneviva, Neal J Thomas, Conrad Krawiec

Open access · bronzeAbstract read
In one paragraph

Article in Journal of child neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 2 pooled it
7.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 2 syntheses or guidelines pooled it, 58 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
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  6. Observational
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  10. Impact of Respiratory Viruses and SARS-CoV-2 on Febrile Seizures in Saudi Children: Insights into Etiologies, Gender, and Familial Associations.Medical science monitor : international medical journal of experimental and clinical research · 2024
    Article
  11. Article
  12. Observational
  13. Article
  14. [Clinical features of children with febrile seizures caused by Omicron variant infection].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2023
    Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. The Impact of Omicron Wave on Pediatric Febrile Seizure.Journal of Korean medical science · 2023
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  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Katsiah Cadet12310Penn State College of Medicine, Hershey, PA, USA.ORCID 0000-0002-5763-8537
Jessica BoegnerPediatrics, Department of Pediatrics, 509393Penn State Hershey Children's Hospital, Hershey, PA, USA.
Gary D CenevivaPediatric Critical Care Medicine, Department of Pediatrics, 509393Penn State Hershey Children's Hospital, Hershey, PA, USA.
Neal J ThomasPediatric Critical Care Medicine, Department of Pediatrics, 509393Penn State Hershey Children's Hospital, Hershey, PA, USA.
Conrad KrawiecPediatric Critical Care Medicine, Department of Pediatrics, 509393Penn State Hershey Children's Hospital, Hershey, PA, USA.ORCID 0000-0001-7902-2568
Penn State Milton S. Hershey Medical Center · USPennsylvania State University · US

Funding

Penn State Clinical and Translational Science InstituteUL1TR002014 · NCATS · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI KRASCHNEWSKI, JENNIFER L. · 2016 to 2025
$33.7M
NCATS NIH HHS UL1 TR002014
6 · The paper itself

Abstract

BACKGROUND/

objectivesInfections with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may be associated with febrile seizures, but the overall frequency and outcomes are unknown. The objectives of this study are to (1) determine the frequency of pediatric subjects diagnosed with febrile seizures and COVID-19, (2) evaluate patient characteristics, and (3) describe the treatments (medications and need for invasive mechanical ventilation) applied.

methodsThis was a retrospective study utilizing TriNetX electronic health record data. We included subjects ranging from 0 to 5 years of age with a diagnosis of febrile seizures (R56.00, R56.01) and COVID-19 (U07.1). We extracted the following data: age, race, ethnicity, diagnostic codes, medications, laboratory results, and procedures.

resultsDuring this study period, 8854 pediatric subjects aged 0-5 years were diagnosed with COVID-19 among 34 health care organizations and 44 (0.5%) were also diagnosed with febrile seizures (simple, 30 [68.2%]; complex, 14 [31.8%]). The median age was 1.5 years (1, 2), there were no reported epilepsy diagnoses, and a proportion required hospitalization (11; 25.0%) and critical care services (4; 9.1%).

conclusionsCOVID-19 infections in children can be associated with febrile seizures. In our study, 0.5% of COVID-19 subjects were diagnosed with febrile seizures and approximately 9% of subjects were reported to require critical care services. Febrile seizures, although serious, are not a commonly diagnosed neurologic manifestation of COVID-19.

Indexed as

COVID-19Seizures, FebrileChildChild, PreschoolHumansInfantInfant, NewbornRespiration, ArtificialRetrospective StudiesSARS-CoV-2coronavirusCOVID-19febrile seizuresneurologic symptoms of SARS-CoV-2respiratory viruses

Identifiers

PMID35286175
PMCPMC9086105
OpenAlexW4220842316

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.