ReviewCirculation2022
Clinical Trial Design Principles and Outcomes Definitions for Device-Based Therapies for Hypertension: A Consensus Document From the Hypertension Academic Research Consortium.
Review in Circulation, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 41 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Efficacy and Safety of Roselle in Patients With Grade 1 Essential Hypertension: A Phase III, Randomized, Double-Blind, Double-Dummy, Active-Controlled Clinical Trial
WEAVE NM Project: Heart Health and Nutrition for Life (HHNL)
Who cites it
41 citing papers in PubMed, 5 syntheses or guidelines pooled it, 71 citations in OpenAlex.
- Are biologically meaningful effect sizes a factor in study design? A systematic review of translational chronic variable stress studies.Experimental physiology · 2026Pooled it
- Optimal dose and effectiveness of different types of physical activity to improve blood pressure in people with type 2 diabetes mellitus: A systematic review and network meta-analysis.Reviews in endocrine & metabolic disorders · 2026Pooled it
- Pharmacist interventions to improve hypertension management among patients with diabetes: a systematic review and meta-analysis of randomized controlled trials.BMC health services research · 2025Pooled it
- Investigation and management of resistant hypertension: British and Irish Hypertension Society position statement.Journal of human hypertension · 2025Guideline
- Effects of Catheter-Based Renal Denervation in Hypertension: A Systematic Review and Meta-Analysis.Circulation · 2024Pooled it
- The effects of simultaneous isometric and eccentric- or concentric-biased exercise on cardiovascular and muscular health of young individuals.European journal of applied physiology · 2026Trial
- Effects of a 12-Week Mediterranean-Type Time-Restricted Feeding Protocol in Patients With Metabolic Dysfunction-Associated Steatotic Liver Disease: A Randomised Controlled Trial-The 'CHRONO-NAFLD Project'.Alimentary pharmacology & therapeutics · 2025Trial
- The Feasibility of Make My Day-A Randomized Controlled Pilot Trial of a Stroke Prevention Program in Primary Healthcare.International journal of environmental research and public health · 2023Trial
- Trial
- Make My Day - Stroke Prevention Grounded in Engaging Everyday Activities in Primary Healthcare - A Single-Blinded Randomised Controlled Trial.Journal of primary care & community healthTrial
- A measurement comparability study to support instrument harmonization in the Canadian Longitudinal Study on Aging.American journal of epidemiology · 2026Article
- Renal denervation for hypertension management in the UK: a Delphi expert consensus.Heart (British Cardiac Society) · 2026Article
- Cardiovascular disease risk factors in women with O-desmethylangolensin producing and non-producing gut microbial metabotypes: an observational study.BMC cardiovascular disorders · 2026Observational
- Optimal Exercise Type and Dose for Blood Pressure Improvement in Middle-Aged and Older Adults with Type 2 Diabetes: A Systematic Review and Network Meta-Analysis.Life (Basel, Switzerland) · 2026Review
- Heart Rate Variability Moderates the Association Between Trait Anxiety and Sympathetic Nerve Activity in Humans.Hypertension (Dallas, Tex. : 1979) · 2026Article
- Evaluating the semi-chronic effects of household air pollution exposure on cardiopulmonary health under two different ventilation conditions.Scientific reports · 2026Article
- Second-Generation Aldosterone Synthase Inhibitors for Hypertension: A Bayesian Meta-Analysis of Randomized Trials.JACC. Advances · 2026Article
- Movement-Based Mindfulness vs. Attention Control for Modifying Physiological Risk in Chronic Stroke: Evidence from a Feasibility Trial.Healthcare (Basel, Switzerland) · 2025Article
- Article
- Renal denervation for hypertension.Nature reviews. Cardiology · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
31 authors at 20 institutions in 10 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The clinical implications of hypertension in addition to a high prevalence of both uncontrolled blood pressure and medication nonadherence promote interest in developing device-based approaches to hypertension treatment. The expansion of device-based therapies and ongoing clinical trials underscores the need for consistency in trial design, conduct, and definitions of clinical study elements to permit trial comparability and data poolability. Standardizing methods of blood pressure assessment, effectiveness measures beyond blood pressure alone, and safety outcomes are paramount. The Hypertension Academic Research Consortium (HARC) document represents an integration of evolving evidence and consensus opinion among leading experts in cardiovascular medicine and hypertension research with regulatory perspectives on clinical trial design and methodology. The HARC document integrates the collective information among device-based therapies for hypertension to better address existing challenges and identify unmet needs for technologies proposed to treat the world's leading cause of death and disability. Consistent with the Academic Research Consortium charter, this document proposes pragmatic consensus clinical design principles and outcomes definitions for studies aimed at evaluating device-based hypertension therapies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.