Evidence map›Paper›PMID 35286058›Full record

ArticleACS nano2022

Photoswitchable Binary Nanopore Conductance and Selective Electronic Detection of Single Biomolecules under Wavelength and Voltage Polarity Control.

James T Hagan, Alejandra Gonzalez, Yuran Shi, Grace G D Han, Jason R Dwyer

Abstract read
In one paragraph

Article in ACS nano, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Solid-State Nanopores for Biomolecular Analysis and Detection.Advances in biochemical engineering/biotechnology · 2024
    Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

James T HaganDepartment of Chemistry, University of Rhode Island, 140 Flagg Road, Kingston, Rhode Island 02881, United States.
Alejandra GonzalezDepartment of Chemistry, Brandeis University, 415 South Street, Waltham, Massachusetts 02453, United States.ORCID 0000-0001-6483-5005
Yuran ShiDepartment of Chemistry, Brandeis University, 415 South Street, Waltham, Massachusetts 02453, United States.ORCID 0000-0003-1136-3694
Grace G D HanDepartment of Chemistry, Brandeis University, 415 South Street, Waltham, Massachusetts 02453, United States.ORCID 0000-0002-2918-1584
Jason R DwyerDepartment of Chemistry, University of Rhode Island, 140 Flagg Road, Kingston, Rhode Island 02881, United States.ORCID 0000-0002-2938-2888

Funding

Chemically Tuned Silicon Nitride Nanopores for Nucleic Acid SequencingR21HG011096 · NHGRI · UNIVERSITY OF RHODE ISLAND · PI DWYER, JASON RODGER · 2020 to 2021
$503k
NHGRI NIH HHS R21 HG011096
6 · The paper itself

Abstract

We fabricated photoregulated thin-film nanopores by covalently linking azobenzene photoswitches to silicon nitride pores with ∼10 nm diameters. The photoresponsive coatings could be repeatedly optically switched with deterministic ∼6 nm changes to the effective nanopore diameter and of ∼3× to the nanopore ionic conductance. The sensitivity to anionic DNA and a neutral complex carbohydrate biopolymer (maltodextrin) could be photoswitched "on" and "off" with an analyte selectivity set by applied voltage polarity. Photocontrol of nanopore state and mass transport characteristics is important for their use as ionic circuit elements (e.g., resistors and binary bits) and as chemically tuned filters. It expands single-molecule sensing capabilities in personalized medicine, genomics, glycomics, and, augmented by voltage polarity selectivity, especially in multiplexed biopolymer information storage schemes. We demonstrate repeatedly photocontrolled stable nanopore size, polarity, conductance, and sensing selectivity, by illumination wavelength and voltage polarity, with broad utility including single-molecule sensing of biologically and technologically important polymers.

Indexed as

NanoporesBiopolymersDNAElectronicsNanotechnologyBiopolymersDNAazobenzeneDNAglycannanoporephotoswitchsilicon nitridesingle-molecule detection

Identifiers

PMID35286058
PMCPMC11659821

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.