Evidence map›Paper›PMID 35286016›Full record

ArticleChemMedChem2022

Design, Synthesis, and Characterization of a Novel Fluoroprobe for Live Human Islet Cell Imaging of Serotonin 5-HT

Robert W Garvey, Enza Lacivita, Mauro Niso, Beata Duszyńska, Paul E Harris, Marcello Leopoldo

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ChemMedChem, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 6 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 3 countries.

Robert W GarveyDivision of Endocrinology, Department of Medicine and Naomi Berrie Diabetes Center, Columbia University Medical Center, New York, NY 10033, USA.
Enza LacivitaDipartimento di Farmacia - Scienze del Farmaco, Università degli Studi di Bari Aldo Moro, Via Orabona 4, 70125, Bari, Italy.ORCID 0000-0003-2443-1174
Mauro NisoDipartimento di Farmacia - Scienze del Farmaco, Università degli Studi di Bari Aldo Moro, Via Orabona 4, 70125, Bari, Italy.
Beata DuszyńskaDepartment of Medicinal Chemistry, Maj Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, 31-343, Krakow, Poland.
Paul E HarrisDivision of Endocrinology, Department of Medicine and Naomi Berrie Diabetes Center, Columbia University Medical Center, New York, NY 10033, USA.
Marcello LeopoldoDipartimento di Farmacia - Scienze del Farmaco, Università degli Studi di Bari Aldo Moro, Via Orabona 4, 70125, Bari, Italy.
University of Bari Aldo Moro · ITColumbia University Irving Medical Center · USMaj Institute of Pharmacology · PL

Funding

Imaging beta cell function for metabolic surgeryR01DK104740 · NIDDK · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI HARRIS, PAUL E · 2015 to 2019
$2.5M
NIDDK NIH HHS R01 DK104740
6 · The paper itself

Abstract

Mounting evidence suggests that the serotonin system serves in signal transmission to regulate insulin secretion in pancreatic islets of Langerhans. Among the 5-HT receptor subtype found in pancreatic islets, serotonin receptor 1A (5-HT

Indexed as

Islets of LangerhansReceptor, Serotonin, 5-HT1A8-Hydroxy-2-(di-n-propylamino)tetralinHumansSerotonin Receptor Agonists8-Hydroxy-2-(di-n-propylamino)tetralinReceptor, Serotonin, 5-HT1ASerotonin Receptor Agonistsdiabetesfluorescent microscopyinsulinisletsserotoninserotonin 1A receptorvesiclesβ-cells

Identifiers

PMID35286016
PMCPMC9127068
OpenAlexW4220979319

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.