ArticleJMIR research protocols2022
Impact of Biological and Lifestyle Factors on Cognitive Aging and Work Ability in the Dortmund Vital Study: Protocol of an Interdisciplinary, Cross-sectional, and Longitudinal Study.
Article in JMIR research protocols, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05155397 (The Dortmund Vital Study), which is not on this map. Cited by 26 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Dortmund Vital Study: Impact of Biological and Lifestyle Factors on Cognitive Performace and Work Ability Across the Lifespan. An Interdisciplinary, Cross-sectional and Longitudinal Study
Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A meta-analysis on the relationship between subjective cognitive failures as measured by the cognitive failures questionnaire (CFQ) and objective performance on executive function tasks.Psychonomic bulletin & review · 2025Pooled it
- Age-dependent modulations of hemispheric small-world networks in different eye states: resting-state electroencephalogram research.GeroScience · 2026Article
- Long-term reliability and stability of parameterized resting state EEG: evidence from a five-year follow-up.Cerebral cortex (New York, N.Y. : 1991) · 2026Article
- Beyond composite scores in chronotype assessment: item-level predictive patterns in the Morningness-Eveningness Questionnaire.Scientific reports · 2026Observational
- Personalized, EEG-controlled intermittent theta burst stimulation.medRxiv : the preprint server for health sciences · 2026Article
- Effects of motor activity versus cognitive demand on asymmetries in EEG frequency bands and their relation to handedness.Frontiers in human neuroscience · 2026Article
- LatentBiomolecules · 2025Article
- Electrophysiological resting-state signatures link polygenic scores to general intelligence.Scientific reports · 2025Observational
- Changes of cognitive functions and proinflammatory cytokines across the lifespan in latentBrain, behavior, & immunity - health · 2025Article
- Evaluating in-vivo spontaneous firing rate in the brain based on neuronal noise modeling.Communications biology · 2025Article
- The association between hair cortisol and burnout is moderated by age, psychosocial, and immunological markers.Brain, behavior, & immunity - health · 2025Article
- Review
- Influence of circadian rhythm on the determination of the IMMune Age indeX (IMMAX).Frontiers in aging · 2025Article
- Resting-state EEG data before and after cognitive activity across the adult lifespan and a 5-year follow-up.Scientific data · 2024Article
- MICROSTATELAB: The EEGLAB Toolbox for Resting-State Microstate Analysis.Brain topography · 2024Article
- On the Reliability of the EEG Microstate Approach.Brain topography · 2024Article
- ChronicLife (Basel, Switzerland) · 2024Article
- Fog Computing for Control of Cyber-Physical Systems in Industry Using BCI.Sensors (Basel, Switzerland) · 2023Article
- From Immunosenescence to Aging Types-Establishing Reference Intervals for Immune Age Biomarkers by Centile Estimation.International journal of molecular sciences · 2023Article
- A Systematic Analysis of Biological, Sociodemographic, Psychosocial, and Lifestyle Factors Contributing to Work Ability Across the Working Life Span: Cross-sectional Study.JMIR formative research · 2023Article
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Authors and funding
17 authors.
Funding
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Abstract
backgroundPrevious research revealed several biological and environmental factors modulating cognitive functioning over a human's lifespan. However, the relationships and interactions between biological factors (eg, genetic polymorphisms, immunological parameters, metabolic products, or infectious diseases) and environmental factors (eg, lifestyle, physical activity, nutrition, and work type or stress at work) as well as their impact on cognitive functions across the lifespan are still poorly understood with respect to their complexity.
objectiveThe goal of the Dortmund Vital Study is to validate previous hypotheses as well as generate and validate new hypotheses about the relationships among aging, working conditions, genetic makeup, stress, metabolic functions, the cardiovascular system, the immune system, and mental performance over the human lifespan with a focus on healthy working adults. The Dortmund Vital Study is a multidisciplinary study involving the Departments of Ergonomics, Immunology, Psychology and Neurosciences, and Toxicology at the Leibniz Research Centre for Working Environment and Human Factors at the Technical University of Dortmund (IfADo) in Germany, as well as several national and international partners.
methodsThe Dortmund Vital Study is designed as a combined cross-sectional and longitudinal study. Approximately 600 healthy subjects aged between 20 and 70 years will participate. A wide range of demographic, psychological, behavioral, sensory, cardiovascular, immunological, and biochemical data, a comprehensive electroencephalography (EEG)-based cognitive test battery as well as structural and functional magnetic resonance imaging (MRI) have been included in the study.
resultsThe study was approved by the Ethics Committee of IfADo in October 2015. The baseline testing was conducted between 2016 and 2021 and will be repeated every 5 years (3 follow-up measures until 2035). As of March 2020 (until the outbreak of the COVID-19 pandemic), 593 participants have been enrolled. Some results from the cross-sectional part of the study were already published, further results will be published soon. Longitudinal data will be analyzed and published by 2025.
conclusionsWe anticipate that the study will shed light on sources of interindividual differences in the alterations of cognitive functioning with increasing age and reveal biological and lifestyle markers contributing to work ability, longevity, and healthy aging on the one hand, and to risk factors for cognitive decline, mild cognitive impairment, or even dementia on the other hand.
trial registrationClinicalTrials.gov NCT05155397; https://clinicaltrials.gov/ct2/show/NCT05155397. INTERNATIONAL REGISTERED REPORT IDENTIFIER (IRRID): DERR1-10.2196/32352.
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