ArticleeLife2022
Adaptation in cone photoreceptors contributes to an unexpected insensitivity of primate On parasol retinal ganglion cells to spatial structure in natural images.
Article in eLife, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- A standard model for the vertebrate retina.Vision research · 2026Article
- Natural motion statistics unify direction computations.bioRxiv : the preprint server for biology · 2026Article
- Distinct inhibitory connectivity motifs could trigger distinct forms of anticipation in the retinal network.Scientific reports · 2026Article
- Modeling spatial contrast sensitivity in responses of primate retinal ganglion cells to natural movies.PLoS computational biology · 2026Article
- Origin and functional impact of early nonlinearities in primate retina.bioRxiv : the preprint server for biology · 2026Article
- Connectivity, Computation, and Plasticity of the Early Visual System.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Review
- Predictably manipulating photoreceptor light responses to reveal their role in downstream visual responses.eLife · 2024Article
- Short-term plasticity and context-dependent circuit function: Insights from retinal circuitry.Science advances · 2024Review
- Applying Super-Resolution and Tomography Concepts to Identify Receptive Field Subunits in the Retina.PLoS computational biology · 2024Article
- Predictably manipulating photoreceptor light responses to reveal their role in downstream visual responses.bioRxiv : the preprint server for biology · 2024Article
- Biophysical neural adaptation mechanisms enable artificial neural networks to capture dynamic retinal computation.Nature communications · 2024Article
- Diversity of Ganglion Cell Responses to Saccade-Like Image Shifts in the Primate Retina.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Predicting and Manipulating Cone Responses to Naturalistic Inputs.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Neural circuits are constructed from nonlinear building blocks, and not surprisingly overall circuit behavior is often strongly nonlinear. But neural circuits can also behave near linearly, and some circuits shift from linear to nonlinear behavior depending on stimulus conditions. Such control of nonlinear circuit behavior is fundamental to neural computation. Here, we study a surprising stimulus dependence of the responses of macaque On (but not Off) parasol retinal ganglion cells: these cells respond nonlinearly to spatial structure in some stimuli but near linearly to spatial structure in others, including natural inputs. We show that these differences in the linearity of the integration of spatial inputs can be explained by a shift in the balance of excitatory and inhibitory synaptic inputs that originates at least partially from adaptation in the cone photoreceptors. More generally, this highlights how subtle asymmetries in signaling - here in the cone signals - can qualitatively alter circuit computation.
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Registered trials
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