Evidence map›Paper›PMID 35285796›Full record

ArticleeLife2022

Associative learning drives longitudinally graded presynaptic plasticity of neurotransmitter release along axonal compartments.

Aaron Stahl, Nathaniel C Noyes, Tamara Boto, Valentina Botero, Connor N Broyles, Miao Jing, Jianzhi Zeng, Lanikea B King, Yulong Li, Ronald L Davis and 1 more

Open access · goldAbstract read
In one paragraph

Article in eLife, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 34 citations in OpenAlex.

  1. Review
  2. Disruption of a selective vesicle pool upon retrograde amnesia dissociates memory at presynaptic terminals.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
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  4. GluN2B mRNA expression and molecular sequence in the brain of pigeons (Journal of advanced veterinary and animal research · 2025
    Article
  5. Article
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  7. Review
  8. Article
  9. Article
  10. Modeling neurodegenerative and neurodevelopmental disorders in theLearning & memory (Cold Spring Harbor, N.Y.) · 2024
    Review
  11. Review
  12. Article
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  16. Article
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  19. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Aaron StahlDepartment of Neuroscience, The Scripps Research Institute, Jupiter, United States.ORCID 0000-0003-3170-1101
Nathaniel C NoyesDepartment of Neuroscience, The Scripps Research Institute, Jupiter, United States.
Tamara BotoDepartment of Neuroscience, The Scripps Research Institute, Jupiter, United States.ORCID 0000-0002-9974-3714
Valentina BoteroDepartment of Neuroscience, The Scripps Research Institute, Jupiter, United States.ORCID 0000-0002-9744-3929
Connor N BroylesDepartment of Neuroscience, The Scripps Research Institute, Jupiter, United States.ORCID 0000-0002-2930-7343
Miao JingChinese Institute for Brain Research, Beijing, China.
Jianzhi ZengPeking-Tsinghua Center for Life Sciences, Peking University, Beijing, China.ORCID 0000-0002-5380-6281
Lanikea B KingDepartment of Neuroscience, The Scripps Research Institute, Jupiter, United States.
Yulong LiChinese Institute for Brain Research, Beijing, China.
Ronald L DavisDepartment of Neuroscience, The Scripps Research Institute, Jupiter, United States.
Seth M TomchikDepartment of Neuroscience, The Scripps Research Institute, Jupiter, United States.ORCID 0000-0001-5686-0833
Scripps Research Institute · USKing University · USChinese Institute for Brain Research · CN

Funding

Resource Component: Acquisition, maintenance and distribution of Drosophila stocksP40OD018537 · OD · TRUSTEES OF INDIANA UNIVERSITY · PI Annette L. Parks · 2014 to 2026
$13.5M
Biology of memoryR35NS097224 · NINDS · UNIVERSITY OF FLORIDA · PI DAVIS, RONALD L · 2017 to 2024
$9.1M
Mechanisms of Nf1 Pathophysiology Underlying HyperactivityR01NS097237 · NINDS · UNIVERSITY OF IOWA · PI TOMCHIK, SETH M · 2017 to 2021
$2.4M
Novel fluorescent sensors based on GPCRs for imaging neuromodulationU01NS103558 · NINDS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI HIRES, SAMUEL ANDREW, LI, YULONG · 2017 to 2019
$2.2M
Dopaminergic circuit modulation of learning and arousal-mediated memory enhancementR01NS114403 · NINDS · UNIVERSITY OF IOWA · PI TOMCHIK, SETH M · 2020 to 2024
$2.0M
The Role of cAMP/PKA Signaling in Neural Circuits Underlying Memory FormationR00MH092294 · NIMH · SCRIPPS RESEARCH INSTITUTE, THE · PI TOMCHIK, SETH M · 2013 to 2015
$747k
NIH HHS P40 OD018537NIMH NIH HHS R00 MH092294NINDS NIH HHS R01 NS097237NINDS NIH HHS R01 NS114403NINDS NIH HHS R35 NS097224NINDS NIH HHS U01 NS103558
6 · The paper itself

Abstract

Anatomical and physiological compartmentalization of neurons is a mechanism to increase the computational capacity of a circuit, and a major question is what role axonal compartmentalization plays. Axonal compartmentalization may enable localized, presynaptic plasticity to alter neuronal output in a flexible, experience-dependent manner. Here, we show that olfactory learning generates compartmentalized, bidirectional plasticity of acetylcholine release that varies across the longitudinal compartments of

Indexed as

AcetylcholineSmellAnimalsAxonsDrosophilaDrosophila melanogasterMushroom BodiesNeuronal PlasticityNeurotransmitter AgentsAcetylcholineNeurotransmitter Agentscav2depressionD. melanogasterhabituationIP3Rneurosciencepotentiationsynaptic

Identifiers

PMID35285796
PMCPMC8956283
OpenAlexW4220705390

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.