Evidence map›Paper›PMID 35285721›Full record

ArticleJournal of palliative medicine2022

Top Ten Tips Palliative Care Clinicians Should Know About Psychedelic-Assisted Therapy in the Context of Serious Illness.

William E Rosa, Zachary Sager, Megan Miller, Ilan Bernstein, Alden Doerner Rinaldi, Katie Addicott, Michael Ljuslin, Chris Adrian, Anthony L Back, Jamie Beachy and 12 more

Registry-linked trialOpen access · greenAbstract read
In one paragraph

Article in Journal of palliative medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07048743 (Psilocybin-assisted Existential, Attachment and Relational), which is not on this map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
8.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07048743 phase2recruitingnot on this mapstarted 2025, after this paper: background citation

Psilocybin-assisted Existential, Attachment and Relational (PEARL) Therapy for Caregivers of Patients With Advanced Cancer: A Phase II Open-Label Trial

TypeinterventionalSponsorUniversity Health Network, TorontoRan2025 to 2027Enrolled15ConditionsCaregiver DistressArmsPsilocybin
3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 48 citations in OpenAlex.

  1. Review
  2. Article
  3. Psychedelic therapy and cultural humility.Translational psychiatry · 2026
    Review
  4. Article
  5. A Rapid Review of Psychedelic-Assisted Therapy in the Context of Palliative Care.Journal of hospice and palliative nursing : JHPN : the official journal of the Hospice and Palliative Nurses Association · 2025
    Article
  6. Article
  7. Psychedelics, epilepsy, and seizures: a review.Frontiers in pharmacology · 2023
    Review
  8. Psilocybin in Palliative Care: An Update.Current geriatrics reports · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors at 17 institutions in 3 countries.

William E RosaDepartment of Psychiatry and Behavioral Sciences, Memorial Sloan Kettering Cancer Center, New York, New York, USA.ORCID 0000-0002-0680-8911
Zachary SagerDepartment of Psychosocial Oncology and Palliative Care, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
Megan MillerSchool of Nursing, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Ilan BernsteinJohn A. Burns School of Medicine, University of Hawai'i at Mānoa, Honolulu, Hawaii, USA.
Alden Doerner RinaldiCare Dimensions Hospice, Waltham, Massachusetts, USA.
Katie AddicottDepartment of Palliative Medicine, Maine Medical Center, Portland, Maine, USA.
Michael LjuslinDepartment of Psychosocial Oncology and Palliative Care, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
Chris AdrianChildren's Hospital, Los Angeles, California, USA.
Anthony L BackDepartment of Medicine, University of Washington, Seattle, Washington, USA.
Jamie BeachyCenter for Contemplative Chaplaincy, Naropa University, Boulder, Colorado, USA.
Anthony P BossisNYU Grossman School of Medicine, New York, New York, USA.
William S BreitbartDepartment of Psychiatry and Behavioral Sciences, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Mary P CosimanoDepartment of Psychiatry and Behavioral Sciences, Center for Psychedelic and Consciousness Research, Johns Hopkins School of Medicine, Baltimore, Maryland, USA.
Stacy M FischerUniversity of Colorado School of Medicine, Aurora, Colorado, USA.
Jeffrey GussNYU Grossman School of Medicine, New York, New York, USA.
Emma KnightonAmerican Psychedelic Practitioners Association, Seattle, Washington, USA.
Janis PhelpsCenter for Psychedelic Therapies and Research, California Institute of Integral Studies, San Francisco, California, USA.
Brian D RichardsDepartment of Psychiatry and Behavioral Sciences, Center for Psychedelic and Consciousness Research, Johns Hopkins School of Medicine, Baltimore, Maryland, USA.
William A RichardsDepartment of Psychiatry and Behavioral Sciences, Center for Psychedelic and Consciousness Research, Johns Hopkins School of Medicine, Baltimore, Maryland, USA.
James A TulskyDepartment of Psychosocial Oncology and Palliative Care, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.ORCID 0000-0002-7458-0453
Monnica T WilliamsSchool of Psychology, University of Ottawa, Ottawa, Ontario, Canada.
Yvan BeaussantDepartment of Psychosocial Oncology and Palliative Care, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.ORCID 0000-0003-3716-6736
Dana-Farber Cancer Institute · USJohns Hopkins University · USMemorial Sloan Kettering Cancer Center · USAmerican Association of Nurse Practitioners · USCalifornia Institute of Integral Studies · USCardiac Dimensions (United States) · USChildren's Hospital of Los Angeles · USInternational Rescue Committee · USMaine Medical Center · USNaropa University · USNYU Langone Health · USUniversity Hospital of Geneva · CHUniversity of Colorado Denver · USUniversity of Hawaiʻi at Mānoa · USUniversity of Ottawa · CAUniversity of Washington · USUniversity of Wisconsin–Madison · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI SELWYN M VICKERS · 1985 to 2026
$347.4M
Psychosocial Palliative & Community Research in CancerT32CA009461 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI JENNIFER L HAY, Jamie S. Ostroff · 1985 to 2026
$10.1M
NCI NIH HHS P30 CA008748NCI NIH HHS T32 CA009461
6 · The paper itself

Abstract

Psychedelic-assisted therapy (PAT) is a burgeoning treatment with growing interest across a variety of settings and disciplines. Empirical evidence supports PAT as a novel therapeutic approach that provides safe and effective treatment for people suffering from a variety of diagnoses, including treatment-resistant depression, substance use disorder, and post-traumatic stress disorder. Within the palliative care (PC) field, one-time PAT dosing may lead to sustained reductions in anxiety, depression, and demoralization-symptoms that diminish the quality of life in both seriously ill patients and those at end of life. Despite a well-noted psychedelic renaissance in scholarship and a renewed public interest in the utilization of these medicines, serious illness-specific content to guide PAT applications in hospice and PC clinical settings has been limited. This article offers 10 evidence-informed tips for PC clinicians synthesized through consultation with interdisciplinary and international leading experts in the field with aims to: (1) familiarize PC clinicians and teams with PAT; (2) identify the unique challenges pertaining to this intervention given the current legalities and logistical barriers; (3) discuss therapeutic competencies and considerations for current and future PAT use in PC; and (4) highlight critical approaches to optimize the safety and potential benefits of PAT among patients with serious illness and their caregivers.

Indexed as

HallucinogensHospice and Palliative Care NursingAnxietyHumansPalliative CareQuality of LifeHallucinogensanxiety treatmentdemoralizationdepressionLSDMDMApalliative carepsilocybinpsychedelic-assisted therapypsychedelicsserious illness

Identifiers

PMID35285721
PMCPMC9467634
OpenAlexW4220907466

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.