Evidence map›Paper›PMID 35285584›Full record

ReviewCancer reports (Hoboken, N.J.)2022

Synchronous tonsillar tumors with differing histopathology: A case report and review of the literature.

Nicholas A Rossi, Devin N Reddy, Jordan W Rawl, Jianli Dong, Suimin Qiu, Cecilia G Clement, Vicente A Resto, Rohan Joshi, Brian McKinnon, Orly Coblens

Open access · goldAbstract readCase ReportsReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cancer reports (Hoboken, N.J.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Nicholas A RossiDepartment of Otolaryngology, University of Texas Medical Branch, Galveston, Texas, USA.ORCID 0000-0002-7105-2196
Devin N ReddySchool of Medicine, University of Texas Medical Branch, Galveston, Texas, USA.ORCID 0000-0002-3700-4385
Jordan W RawlDepartment of Otolaryngology, University of Texas Medical Branch, Galveston, Texas, USA.
Jianli DongDepartment of Pathology, University of Texas Medical Branch, Galveston, Texas, USA.
Suimin QiuDepartment of Pathology, University of Texas Medical Branch, Galveston, Texas, USA.
Cecilia G ClementDepartment of Pathology, University of Texas Medical Branch, Galveston, Texas, USA.
Vicente A RestoDepartment of Otolaryngology, University of Texas Medical Branch, Galveston, Texas, USA.
Rohan JoshiDepartment of Otolaryngology, University of Texas Medical Branch, Galveston, Texas, USA.
Brian McKinnonDepartment of Otolaryngology, University of Texas Medical Branch, Galveston, Texas, USA.ORCID 0000-0002-2257-4721
Orly CoblensDepartment of Otolaryngology, University of Texas Medical Branch, Galveston, Texas, USA.
The University of Texas Medical Branch at Galveston · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTonsillar squamous cell carcinoma (TSCC) due to human papillomavirus (HPV) infection has seen a dramatic increase in recent years. Bilateral tonsillar squamous cell carcinoma (biTSCC) has a much lower incidence than unilateral TSCC and three main hypotheses of biTSCC pathogenesis prevail: field carcinogenesis, single-clone, and multiple HPV infections. CASE: A 49-year-old Male with a remote history of chewing tobacco presented with symptoms of spitting up tissue and occasional hemoptysis. Physical exam showed a sole left tonsillar mass which was confirmed to be TSCC on biopsy. The patient's computed tomographic (CT) scan was consistent with this finding; however, positron emission tomography (PET) scan indicated a second tumor in the contralateral right tonsil. Surgical resection of both masses and selective neck dissection was performed, and the specimens were sent for further pathological analysis. No complications of surgery were noted and the final diagnosis of synchronous biTSCC was made. The tumors were a T2N0M0 left poorly differentiated TSCC (p16+, EGFR+, bcl2+) with basaloid features, and a T1N0M0 right well to moderately differentiated TSCC (p16+, EGFR+, bcl2-).

conclusionOur present case was notable for differing tumor pathology and karyotype analysis between the right and left masses, directly supporting the multiple HPV infections hypothesis of biTSCC pathogenesis. Further genetic characterization of tonsillar tumors is needed to better characterize TSCC and best guide medical/surgical therapy.

Indexed as

Carcinoma, Squamous CellNeoplasms, Multiple PrimaryPapillomavirus InfectionsTonsillar NeoplasmsErbB ReceptorsHumansMaleMiddle AgedPalatine TonsilProto-Oncogene Proteins c-bcl-2ErbB ReceptorsProto-Oncogene Proteins c-bcl-2

Identifiers

PMID35285584
PMCPMC9458503
OpenAlexW4220684390

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.