Evidence map›Paper›PMID 35285473›Full record

ArticleG3 (Bethesda, Md.)2022

GeneCup: mining PubMed and GWAS catalog for gene-keyword relationships.

Mustafa H Gunturkun, Efraim Flashner, Tengfei Wang, Megan K Mulligan, Robert W Williams, Pjotr Prins, Hao Chen

Abstract read
In one paragraph

Article in G3 (Bethesda, Md.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Genomic Loci Influencing Cue-Reactivity in Heterogeneous Stock Rats.bioRxiv : the preprint server for biology · 2024
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Mustafa H GunturkunDepartment of Pharmacology, Addiction Science and Toxicology, University of Tennessee Health Science, Memphis, TN 38103, USA.ORCID 0000-0003-0612-6432
Efraim FlashnerDepartment of Genetics, Genomics and Informatics, University of Tennessee Health Science, Memphis, TN 38103, USA.
Tengfei WangDepartment of Pharmacology, Addiction Science and Toxicology, University of Tennessee Health Science, Memphis, TN 38103, USA.ORCID 0000-0003-3527-3394
Megan K MulliganDepartment of Genetics, Genomics and Informatics, University of Tennessee Health Science, Memphis, TN 38103, USA.ORCID 0000-0003-4909-635X
Robert W WilliamsDepartment of Genetics, Genomics and Informatics, University of Tennessee Health Science, Memphis, TN 38103, USA.ORCID 0000-0001-8924-4447
Pjotr PrinsDepartment of Genetics, Genomics and Informatics, University of Tennessee Health Science, Memphis, TN 38103, USA.ORCID 0000-0002-8021-9162
Hao ChenDepartment of Pharmacology, Addiction Science and Toxicology, University of Tennessee Health Science, Memphis, TN 38103, USA.ORCID 0000-0002-2680-6921

Funding

TIM Project NIDA P30 CenterP30DA044223 · NIDA · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI WILLIAMS, ROBERT W. · 2017 to 2021
$3.9M
A Unified High Performance Web Service for Systems Genetics and Precision MedicineR01GM123489 · NIGMS · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI PRINS, PJOTR, SEN, SAUNAK · 2017 to 2024
$3.7M
System genetics of menthol and nicotine addictionU01DA047638 · NIDA · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI CHEN, HAO, WILLIAMS, ROBERT W. · 2019 to 2023
$3.1M
NIDA NIH HHS P30 DA044223NIDA NIH HHS U01 DA047638NIGMS NIH HHS R01 GM123489
6 · The paper itself

Abstract

Interpreting and integrating results from omics studies typically requires a comprehensive and time consuming survey of extant literature. GeneCup is a literature mining web service that retrieves sentences containing user-provided gene symbols and keywords from PubMed abstracts. The keywords are organized into an ontology and can be extended to include results from human genome-wide association studies. We provide a drug addiction keyword ontology that contains over 300 keywords as an example. The literature search is conducted by querying the PubMed server using a programming interface, which is followed by retrieving abstracts from a local copy of the PubMed archive. The main results presented to the user are sentences where gene symbol and keywords co-occur. These sentences are presented through an interactive graphical interface or as tables. All results are linked to the original abstract in PubMed. In addition, a convolutional neural network is employed to distinguish sentences describing systemic stress from those describing cellular stress. The automated and comprehensive search strategy provided by GeneCup facilitates the integration of new discoveries from omic studies with existing literature. GeneCup is free and open source software. The source code of GeneCup and the link to a running instance is available at https://github.com/hakangunturkun/GeneCup.

Indexed as

Genome-Wide Association StudySoftwareHumansInternetPubMedUser-Computer Interfaceaddictioncustom ontologyliterature miningPubMedweb service

Identifiers

PMID35285473
PMCPMC9073678

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.